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MeSH Review

Alfalfa Mosaic Virus

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Disease relevance of Alfalfa Mosaic Virus


High impact information on Alfalfa Mosaic Virus

  • We used the untranslated leader from the coat protein mRNA of alfalfa mosaic virus (AMV RNA 4), a well-translated, highly competitive message, to replace the leader sequence of barley alpha-amylase (B alpha A) and human interleukin 1 beta (IL-1 beta) cDNAs [5].
  • Initiation of polypeptide synthesis with various NH2-blocked aminoacyl-tRNAs under the direction of alfalfa mosaic virus RNA 4 [6].
  • We report that the competitive translational activity of alfalfa mosaic virus coat protein mRNA (CP RNA), a nonadenylated mRNA, is determined in part by the 3' untranslated region (UTR) [7].
  • Hydroxyl radical footprinting data show that five sites in the 3' UTR of alfalfa mosaic virus RNA 4 are protected by coat protein, and four of the five protected regions contain AUGC or UUGC [8].
  • This polymerase activity was stimulated by oligonucleotides such as (A)nG, cap analogs such as m7GpppAm, and natural mRNAs such as alfalfa mosaic virus RNA 4 [9].

Chemical compound and disease context of Alfalfa Mosaic Virus


Biological context of Alfalfa Mosaic Virus

  • Tobacco plants transformed with the P1 and P2 replicase genes of alfalfa mosaic virus (AIMV) have been shown to produce functional replicase proteins, permitting their infection with AIMV inocula lacking the genome segments encoding P1 and P2, respectively [15].

Anatomical context of Alfalfa Mosaic Virus


Gene context of Alfalfa Mosaic Virus

  • Replicase-mediated resistance to alfalfa mosaic virus [15].
  • RNA 3 of Alfalfa mosaic virus (AMV) encodes the movement protein (MP) and coat protein (CP) [16].
  • The movement protein (MP) and coat protein (CP) encoded by Alfalfa mosaic virus (AMV) RNA 3 are both required for virus transport [17].
  • Computer-assisted comparisons indicate an ancestral relationship between the 3a proteins of CMV, BMV, and alfalfa mosaic virus (AMV) and between the coat proteins of CMV and BMV [18].
  • For expression of both UL54 and UL44, a truncated form of the alfalfa mosaic virus (AMV) RNA4 5'-UTR was found to be superior to the full-length AMV 5'-UTR or the original HCMV 5'-UTRs of different lengths [19].

Analytical, diagnostic and therapeutic context of Alfalfa Mosaic Virus


  1. Characterization of wheat germ protein synthesis initiation factor eIF-4C and comparison of eIF-4C from wheat germ and rabbit reticulocytes. Timmer, R.T., Lax, S.R., Hughes, D.L., Merrick, W.C., Ravel, J.M., Browning, K.S. J. Biol. Chem. (1993) [Pubmed]
  2. In vitro transcription by the turnip yellow mosaic virus RNA polymerase: a comparison with the alfalfa mosaic virus and brome mosaic virus replicases. Deiman, B.A., Verlaan, P.W., Pleij, C.W. J. Virol. (2000) [Pubmed]
  3. The complete nucleotide sequence of prune dwarf ilarvirus RNA 3: implications for coat protein activation of genome replication in ilarviruses. Bachman, E.J., Scott, S.W., Xin, G., Vance, V.B. Virology (1994) [Pubmed]
  4. Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine. Yusibov, V., Hooper, D.C., Spitsin, S.V., Fleysh, N., Kean, R.B., Mikheeva, T., Deka, D., Karasev, A., Cox, S., Randall, J., Koprowski, H. Vaccine (2002) [Pubmed]
  5. Enhanced translation of chimaeric messenger RNAs containing a plant viral untranslated leader sequence. Jobling, S.A., Gehrke, L. Nature (1987) [Pubmed]
  6. Initiation of polypeptide synthesis with various NH2-blocked aminoacyl-tRNAs under the direction of alfalfa mosaic virus RNA 4. Castel, A., Kraal, B., Kerklaan, P.R., Klok, J., Bosch, L. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  7. Identification of a competitive translation determinant in the 3' untranslated region of alfalfa mosaic virus coat protein mRNA. Hann, L.E., Webb, A.C., Cai, J.M., Gehrke, L. Mol. Cell. Biol. (1997) [Pubmed]
  8. Nucleotide sequence and structural determinants of specific binding of coat protein or coat protein peptides to the 3' untranslated region of alfalfa mosaic virus RNA 4. Houser-Scott, F., Baer, M.L., Liem, K.F., Cai, J.M., Gehrke, L. J. Virol. (1994) [Pubmed]
  9. La Crosse virions contain a primer-stimulated RNA polymerase and a methylated cap-dependent endonuclease. Patterson, J.L., Holloway, B., Kolakofsky, D. J. Virol. (1984) [Pubmed]
  10. Inhibition of alfalfa mosaic virus RNA and protein synthesis by actinomycin D and cycloheximide. Nassuth, A., Alblas, F., van der Geest, A.J., Bol, J.F. Virology (1983) [Pubmed]
  11. Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. Boyce, M., Scott, F., Guogas, L.M., Gehrke, L. J. Mol. Recognit. (2006) [Pubmed]
  12. Structural studies on the coat protein of alfalfa mosaic virus. Isolation and characterization of the tryptic peptides and the alignment of the cyanogen-bromide fragments. Van Beynum, G.M., Kraal, B., De Graaf, J.M., Bosch, L. Eur. J. Biochem. (1975) [Pubmed]
  13. In vitro synthesis and processing of a bean pathogenesis-related (PR4) protein. De Tapia, M., Dietrich, A., Burkard, G. Eur. J. Biochem. (1987) [Pubmed]
  14. Effect of glutaraldehyde-fixation on the immunogenicity, particle stability and antigenic reactivity of alfalfa mosaic virus, and the specificity of elicited antibodies. Hajimorad, M.R., Francki, R.I. J. Virol. Methods (1991) [Pubmed]
  15. Replicase-mediated resistance to alfalfa mosaic virus. Brederode, F.T., Taschner, P.E., Posthumus, E., Bol, J.F. Virology (1995) [Pubmed]
  16. Cell-to-cell movement of Alfalfa mosaic virus can be mediated by the movement proteins of Ilar-, bromo-, cucumo-, tobamo- and comoviruses and does not require virion formation. Sánchez-Navarro, J.A., Carmen Herranz, M., Pallás, V. Virology (2006) [Pubmed]
  17. Role of the alfalfa mosaic virus movement protein and coat protein in virus transport. Sánchez-Navarro, J.A., Bol, J.F. Mol. Plant Microbe Interact. (2001) [Pubmed]
  18. Further implications for the evolutionary relationships between tripartite plant viruses based on cucumber mosaic virus RNA 3. Davies, C., Symons, R.H. Virology (1988) [Pubmed]
  19. Expression of the catalytic subunit (UL54) and the accessory protein (UL44) of human cytomegalovirus DNA polymerase in a coupled in vitro transcription/translation system. Cihlar, T., Fuller, M.D., Cherrington, J.M. Protein Expr. Purif. (1997) [Pubmed]
  20. Some observations on the binding properties of alfalfa mosaic virus to polystyrene and its significance to indirect ELISA. Hajimorad, M.R., Francki, R.I. Arch. Virol. (1991) [Pubmed]
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