Disease relevance of Nephroma, Mesoblastic

• ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma [1].
• Renin messenger (m) RNA distribution was studied in congenital mesoblastic nephroma, a usually benign renal tumour of early infancy which may be associated with excess renin production and hypertension [2].
• In the patient in whom cystic nephroma was suspected mesoblastic nephroma was confirmed by the National Wilms Tumor Study Pathology Center. CONCLUSIONS: An unequivocal diagnosis of multicystic dysplastic kidney should be made early in life [3].
• We studied the expression of insulin-like growth factor II (IGF2) and Wilms' tumor gene (WT1) in nine cases of congenital mesoblastic nephroma (CMN) and five cases of first trimester fetal kidneys by in situ hybridization [4].
• RESULTS: At review of the nephrectomy slides, the diagnoses were: Wilms tumor (16 patients), with anaplasia in one case, rhabdoid tumor (2 patients), neuroblastoma (2 patients), mesoblastic nephroma (2 patients), clear cell sarcoma (1 patient), malignant teratoma (1 patient), and renal cell carcinoma (1 patient) [5].

High impact information on Nephroma, Mesoblastic

• Renin messenger RNA localization in congenital mesoblastic nephroma using in situ hybridization [2].
• Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors [6].
• Identification of an acidic fibroblast growth factor-like activity in a mesoblastic nephroma [7].
• Renal transplacental carcinogenicity of 3,3-dimethyl-1-phenyltriazene in rats: relationship of renal mesenchymal tumor to congenital mesoblastic nephroma and intralobar nephrogenic rests [8].
• Pediatric case of the day. Congenital mesoblastic nephroma [9].

Chemical compound and disease context of Nephroma, Mesoblastic

• We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks [6].
• Four and 24-hour imaging of mesoblastic nephroma with Tc-99m DMSA [10].

Biological context of Nephroma, Mesoblastic

• ETV6-NTRK3 fusion gene transcripts that result from t(12; 15)(p13;q25), which is characteristic of cellular congenital mesoblastic nephroma, were not demonstrated [11].
• 847 of them had a histological proven Wilms Tumor, of whom 637 were unilateral localized, and 173 tumors had an other histology [40 congenital mesoblastic nephroma (CMN), 51 clear cell sarcoma (CCSK), 24 rhabdoid tumor (RTK) and 58 other tumors] [12].

Gene context of Nephroma, Mesoblastic

• OBJECTIVES: To describe a case of congenital mesoblastic nephroma (CMN) treated by radical nephrectomy with no evidence of relapses after five years in spite of an unusual positivity for proliferating cellular nuclear antigen (PCNA) [13].
• The histogenetic relationship to congenital mesoblastic nephroma, Wilms tumor and other tumors is discussed [14].
• Mesoblastic nephroma contained fibronectin but no laminin [15].

References