Disease relevance of Vestibulocochlear Nerve

• Neurofibromatosis type 2 (NF2) is a genetic disorder characterized by bilateral schwannomas of the eighth cranial nerve [1].
• Enhancement of the eighth cranial nerve and labyrinth on MR imaging in sudden sensorineural hearing loss associated with human herpesvirus 1 infection: case report [2].
• CONCLUSIONS: It is the authors' opinion that sensorineural hearing loss and positive findings on magnetic resonance imaging are the most reliable evidence for the presence of tinnitus caused by NVC of the eighth cranial nerve [3].
• We conclude that thrice daily aerosol tobramycin administration for 3 months is not associated with detectable eighth cranial nerve or renal toxicity [4].
• None of the patients' MRIs exhibited contrast enhancement of the labyrinth, vestibulocochlear nerve, or vestibular ganglion, even when high doses of gadolinium (0.2 mmol/kg) were used [5].

High impact information on Vestibulocochlear Nerve

• Inactivating NF2 mutations occur in several sporadic tumor types and have been linked to the NF2 disease, whose hallmark is the development of bilateral Schwann cell tumors (schwannomas) of the eighth cranial nerve [6].
• We conclude that prolonged mild exposure to carbon monoxide during development causes measurable functional changes at the level of the eighth cranial nerve [7].
• Reaction product appeared in the medial one-third of the eighth cranial nerve fibers as they penetrated the medulla [8].
• Lidocaine injections (0.5-2 microl of 0.5%) into the root of the eighth cranial nerve within the cranium caused rapid effects on unit responses to head rotation [9].
• In this study, we show that TGF beta is expressed in situ by adult auditory neurons in response to traumatic injury (i.e. transection of the eighth cranial nerve) [10].

Associations of Vestibulocochlear Nerve with chemical compounds

• Streptomycin and kanamycin are associated with eighth cranial nerve damage and should be avoided if possible during cyesis [11].
• Screening for eighth cranial nerve, renal, hepatic and haematological function, before, during, and after gentamicin treatment, revealed no adverse reactions in these patients [12].

Gene context of Vestibulocochlear Nerve

• High density P2X2 immunoreactivity was also observed in the vestibulocochlear nerve fibres [13].
• CONCLUSION: The functions of the eighth cranial nerve and brainstem were highly impaired in severe COPD [14].
• Reduced size of the cochlear branch of the vestibulocochlear nerve in a child with sensorineural hearing loss [15].
• Neurons interspersed in the adjoining vestibulocochlear nerve were also found to elicit Fos [16].
• In animals with cut and regenerating vestibulocochlear nerve, the distribution of the ECM molecules in the CNS and PNS characteristically changed from that of the normal pattern [17].

Analytical, diagnostic and therapeutic context of Vestibulocochlear Nerve

• We suggest a possible association between a Chiari-I malformation and isolated asymmetric sensorineural hearing loss secondary to long-standing traction on the eighth cranial nerve [18].

References