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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nystagmus, Pathologic

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  • As a result of an investigation of the three (horizontal, vertical and torsional) components of the nystagmus elicited by the caloric stimulus (cold water), the vertical nystagmus differed in direction between the left and the right ear in 3 out of the 4 BPPV cases [18].
  • Other ocular abnormalities included strabismus and jerky horizontal nystagmus [19].
  • In addition, moderate myopia and pendular nystagmus were seen in affected individuals [20].
  • Our findings suggest that, in MS, pendular nystagmus arises from an instability in the feedback control of the neural integrator for eye movements, which depends on a distributed network of neurons in the brainstem and cerebellum [21].
  • R24571, a calmodulin antagonist and inhibitor of several Ca(2+)-dependent enzymes, caused a significant reduction in the average frequency of spontaneous ocular nystagmus (spontaneous nystagmus) during the first 53 h following unilateral labyrinthectomy (n = 5), compared with vehicle-injected animals (n = 5) [22].


  1. Periodic alternating nystagmus in a case of hereditary ataxia and its treatment with baclofen. Plant, G.T. J. Neurol. Neurosurg. Psychiatr. (1982) [Pubmed]
  2. Effectiveness of trihexyphenidyl against pendular nystagmus and palatal myoclonus: evidence of cholinergic dysfunction. Jabbari, B., Rosenberg, M., Scherokman, B., Gunderson, C.H., McBurney, J.W., McClintock, W. Mov. Disord. (1987) [Pubmed]
  3. Two sibs with different phenotypes due to adjacent-1 segregation of a subtle translocation t(4;5)(p16.3;p15.3)mat. Qumsiyeh, M.B., Stevens, C.A. Am. J. Med. Genet. (1993) [Pubmed]
  4. Spasmus nutans. A benign clinical entity? King, R.A., Nelson, L.B., Wagner, R.S. Arch. Ophthalmol. (1986) [Pubmed]
  5. Combined pharmacologic and surgical approach to acquired nystagmus due to multiple sclerosis. Jain, S., Proudlock, F., Constantinescu, C.S., Gottlob, I. Am. J. Ophthalmol. (2002) [Pubmed]
  6. Periodic alternating nystagmus in two children with a similar, unusual phenotype. Valmaggia, C., Gottlob, I. Pediatric neurology. (2000) [Pubmed]
  7. A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus. Averbuch-Heller, L., Tusa, R.J., Fuhry, L., Rottach, K.G., Ganser, G.L., Heide, W., Büttner, U., Leigh, R.J. Ann. Neurol. (1997) [Pubmed]
  8. Spinocerebellar ataxia type 6: gaze-evoked and vertical nystagmus, Purkinje cell degeneration, and variable age of onset. Gomez, C.M., Thompson, R.M., Gammack, J.T., Perlman, S.L., Dobyns, W.B., Truwit, C.L., Zee, D.S., Clark, H.B., Anderson, J.H. Ann. Neurol. (1997) [Pubmed]
  9. Acquired pendular nystagmus in toluene addiction. Maas, E.F., Ashe, J., Spiegel, P., Zee, D.S., Leigh, R.J. Neurology (1991) [Pubmed]
  10. Ethanol-induced resolution of pathologic nystagmus. Lepore, F.E. Neurology (1987) [Pubmed]
  11. Trihexyphenidyl treatment of vertical pendular nystagmus. Herishanu, Y., Louzoun, Z. Neurology (1986) [Pubmed]
  12. Treatment of periodic alternating nystagmus. Halmagyi, G.M., Rudge, P., Gresty, M.A., Leigh, R.J., Zee, D.S. Ann. Neurol. (1980) [Pubmed]
  13. Periodic alternating nystagmus in phenytoin intoxication. Campbell, W.W. Arch. Neurol. (1980) [Pubmed]
  14. A reexamination of end-point and rebound nystagmus in normals. Shallo-Hoffmann, J., Schwarze, H., Simonsz, H.J., Mühlendyck, H. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  15. Gabapentin but not vigabatrin is effective in the treatment of acquired nystagmus in multiple sclerosis: How valid is the GABAergic hypothesis? Bandini, F., Castello, E., Mazzella, L., Mancardi, G.L., Solaro, C. J. Neurol. Neurosurg. Psychiatr. (2001) [Pubmed]
  16. Directional effect of inactivation of the nucleus of the optic tract on optokinetic nystagmus in the cat. Hoffmann, K.P., Fischer, W.H. Vision Res. (2001) [Pubmed]
  17. X-linked infantile periodic alternating nystagmus. Hertle, R.W., Yang, D., Kelly, K., Hill, V.M., Atkin, J., Seward, A. Ophthalmic Genet. (2005) [Pubmed]
  18. Evaluation of vertical semicircular canal function by the caloric test--a study on patients with benign paroxysmal positional vertigo. Iida, M., Naitoh, A., Aihara, H., Takahashi, H., Hitouji, K., Nomura, K. Tokai J. Exp. Clin. Med. (1998) [Pubmed]
  19. Cataracts and ketotic hypoglycemia. Wets, B., Milot, J.A., Polomeno, R.C., Letarte, J. Ophthalmology (1982) [Pubmed]
  20. Autosomal dominant cone-rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D, which encodes retinal guanylate cyclase. Gregory-Evans, K., Kelsell, R.E., Gregory-Evans, C.Y., Downes, S.M., Fitzke, F.W., Holder, G.E., Simunovic, M., Mollon, J.D., Taylor, R., Hunt, D.M., Bird, A.C., Moore, A.T. Ophthalmology (2000) [Pubmed]
  21. Experimental tests of a neural-network model for ocular oscillations caused by disease of central myelin. Das, V.E., Oruganti, P., Kramer, P.D., Leigh, R.J. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2000) [Pubmed]
  22. Injections of calmidazolium chloride into the ipsilateral medial vestibular nucleus or fourth ventricle reduce spontaneous ocular nystagmus following unilateral labyrinthectomy in guinea pigs. Sansom, A.J., Darlington, C.L., Smith, P.F., Gilchrist, D.P., Keenan, C.J., Kenyon, R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1993) [Pubmed]
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