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BPPV  -  vestibulopathy, familial

Homo sapiens

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Disease relevance of BPPV


Psychiatry related information on BPPV


High impact information on BPPV

  • We compared the efficacy of a modified Epley's procedure (MEP) and Brandt-Daroff exercises (BDE) for self-treatment of benign paroxysmal positional vertigo of the posterior semicircular canal (PC-BPPV) in 54 patients [9].
  • Nevertheless, despite their important contributions, neither Bárány nor Dix and Hallpike understood the pathophysiology of BPPV nor did they appreciate that the positioning techniques they used actually demonstrated pathology in the semicircular canals rather than the utricle [10].
  • CONCLUSION: It is argued that some patients with idiopathic pDBN have benign paroxysmal positional vertigo (BPPV) with lithiasis of the anterior canal [11].
  • AIM: To compare patients with BPPV referred initially to a Falls and Syncope Unit (FSS group) with those initially referred to a Regional ENT/Balance Service (ENT group) [12].
  • First, the abnormal stimulus being applied to the vestibular system during BPPV episodes is estimated by an analysis of the vestibulo-ocular reflex (VOR) response of clinical BPPV patients [13].

Chemical compound and disease context of BPPV


Biological context of BPPV

  • The atypical ageotropic paroxysmal positional nystagmus of the posterior semicircular canal was observed in the evolution of the BPPV in 2 patients and on the first examination in the third [16].
  • Especially, the similarity index tended to reflect the clinical course of the vestibular compensation and the findings in the patients with benign paroxysmal positional vertigo (BPPV) demonstrated that its vestibular function may include various pathologies besides canalithiasis [17].
  • In BPPV, the torsional component of eye movements was larger than that of the vertical component without obvious horizontal eye deviation [18].
  • In the patient with bilateral BPPV, no change of the pulse rate was observed after rotation toward the right or to the left posterior canal [19].
  • We compared the results obtained by Prolonged Position with two other physical therapies by dividing our horizontal canal BPPV patients into three therapeutic groups: 1) 35 patients treated with Prolonged Position; 2) 24 patients treated with head shaking in a supine position; 3) 15 patients for whom therapy was omitted [20].

Anatomical context of BPPV

  • The modern understanding of the pathophysiology of BPPV began with Schuknecht's proposal that the dysfunction resulted from the gravity-dependent movement of loose or fixed dense material within the posterior semicircular canal ("cupulolithiasis") [10].
  • All patients presented with intractable BPPV that did not respond completely to otolith repositioning procedures [21].
  • Additionally, 70 archived temporal bones without a history of BPPV were examined microscopically for the presence of particulate matter within the lumen of the membranous labyrinth [22].
  • The recent demonstration of free-floating particles in the endolymph of the posterior semicircular canal in patients with benign paroxysmal positional vertigo (BPPV) has renewed interest in the physiology and treatment of this entity [23].
  • This difference was not significant (chi = 0.17, P =.68) CONCLUSION: For the treatment of posterior canal BPPV, concurrent mastoid oscillation with CRP does not significantly alter the short-term outcome [24].

Associations of BPPV with chemical compounds

  • Twelve consecutive patients with intractable BPPV underwent PCO by three surgeons, six with mechanical PCO and six with CO2 laser-assisted PCO [25].
  • RESULTS: Control subjects smoked significantly more often than BPPV patients, and patients without recurrence more frequently than patients with recurrence [6].

Other interactions of BPPV

  • Recently, we reviewed our four-year experience with new onset vertigo in our university-based MS population and found that benign paroxysmal positioning vertigo (BPPV) to be the most common cause [26].
  • METHODS: A retrospective chart review of 107 patients diagnosed with BPPV at our institution between March of 1993 and June of 1995 [27].
  • We describe two patients with intractable BPPV and profound sensorineural hearing loss in the affected ear treated by transmastoid posterior semicircular canal occlusion [28].
  • This paper presents a combined procedure for the management of intractable benign paroxysmal positional vertigo (BPPV) and profound hearing loss in a patient with far advanced otosclerosis [29].

Analytical, diagnostic and therapeutic context of BPPV

  • Speech induced an increase in inspiratory time during BPPV, with a greater increase in the volume released by the ventilator during speech as compared with ACV (172 +/- 194 versus 26 +/- 31 ml) [2].
  • BPPV is suggested by history, readily diagnosed by office examination, and cured by appropriate exercise therapy [30].
  • OBJECTIVES--To review the clinical features, electronystagmography findings, the possible mechanism, and a possible therapeutic approach to benign paroxysmal positional vertigo (BPPV) [31].
  • In two cases, BPPV occurred when patients moved their head while maintaining strict bedrest [32].
  • An Internet survey of the relevant literature in English shows a scarcity of publications on the incidence of BPPV following stapedectomy [33].


  1. Selective vestibular damage in neurosarcoidosis. von Brevern, M., Lempert, T., Bronstein, A.M., Kocen, R. Ann. Neurol. (1997) [Pubmed]
  2. Comparative effects of two ventilatory modes on speech in tracheostomized patients with neuromuscular disease. Prigent, H., Samuel, C., Louis, B., Abinun, M.F., Zerah-Lancner, F., Lejaille, M., Raphael, J.C., Lofaso, F. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  3. Click evoked myogenic potentials in the differential diagnosis of acute vertigo. Heide, G., Freitag, S., Wollenberg, I., Iro, H., Schimrigk, K., Dillmann, U. J. Neurol. Neurosurg. Psychiatr. (1999) [Pubmed]
  4. Interaction of somatoform and vestibular disorders. Best, C., Eckhardt-Henn, A., Diener, G., Bense, S., Breuer, P., Dieterich, M. J. Neurol. Neurosurg. Psychiatr. (2006) [Pubmed]
  5. Vertigo and dizziness related to migraine: a diagnostic challenge. Neuhauser, H., Lempert, T. Cephalalgia : an international journal of headache. (2004) [Pubmed]
  6. Effects of cigarettes and alcohol consumption in benign paroxysmal positioning vertigo. Sunami, K., Tochino, R., Tokuhara, Y., Yamamoto, H., Tomita, S., Koshimo, N., Yamane, H. Acta Otolaryngol. (2006) [Pubmed]
  7. Psychological findings in benign paroxysmal positional vertigo and psychogenic vertigo. Nagarkar, A.N., Gupta, A.K., Mann, S.B. The Journal of otolaryngology. (2000) [Pubmed]
  8. Life events and benign paroxysmal positional vertigo: a case-controlled study. Monzani, D., Genovese, E., Rovatti, V., Malagoli, M.L., Rigatelli, M., Guidetti, G. Acta Otolaryngol. (2006) [Pubmed]
  9. A modified Epley's procedure for self-treatment of benign paroxysmal positional vertigo. Radtke, A., Neuhauser, H., von Brevern, M., Lempert, T. Neurology (1999) [Pubmed]
  10. Benign paroxysmal positioning vertigo: classic descriptions, origins of the provocative positioning technique, and conceptual developments. Lanska, D.J., Remler, B. Neurology (1997) [Pubmed]
  11. Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. Bertholon, P., Bronstein, A.M., Davies, R.A., Rudge, P., Thilo, K.V. J. Neurol. Neurosurg. Psychiatr. (2002) [Pubmed]
  12. Benign paroxysmal positional vertigo: clinical characteristics of dizzy patients referred to a Falls and Syncope Unit. Lawson, J., Johnson, I., Bamiou, D.E., Newton, J.L. QJM : monthly journal of the Association of Physicians. (2005) [Pubmed]
  13. Theoretical models for the mechanisms of benign paroxysmal positional vertigo. House, M.G., Honrubia, V. Audiol. Neurootol. (2003) [Pubmed]
  14. Benign paroxysmal positional vertigo in patients with Ménière's disease treated with intratympanic gentamycin. Perez, N., Martin, E., Zubieta, J.L., Romero, M.D., Garcia-Tapia, R. Laryngoscope (2002) [Pubmed]
  15. A mathematical model for top-shelf vertigo: the role of sedimenting otoconia in BPPV. Squires, T.M., Weidman, M.S., Hain, T.C., Stone, H.A. Journal of biomechanics. (2004) [Pubmed]
  16. Posterior semicircular canal type benign paroxysmal positioning vertigo with ageotropic paroxysmal positioning nystagmus. Rapoport, A., Sadeh, M. Audiol. Neurootol. (2001) [Pubmed]
  17. Nonlinear analysis of orthostatic posture in patients with vertigo or balance disorders. Sasaki, O., Gagey, P.M., Ouaknine, A.M., Martinerie, J., Le Van Quyen, M., Toupet, M., L'Heritier, A. Neurosci. Res. (2001) [Pubmed]
  18. Nystagmus in benign paroxysmal positional vertigo: a three-component analysis. Yagi, T., Ushio, K. Acta oto-laryngologica. Supplementum. (1995) [Pubmed]
  19. Benign paroxysmal positional vertigo can interfere with the cardiac response to head-down tilt. Jáuregui-Renaud, K., Aw, S.T., Todd, M.J., McGarvie, L.A., Halmagyi, G.M. Otol. Neurotol. (2005) [Pubmed]
  20. Treatment of horizontal semicircular canal benign paroxysmal positional vertigo. Vannucchi, P., Giannoni, B., Pagnini, P. Journal of vestibular research : equilibrium & orientation. (1997) [Pubmed]
  21. Intractable benign paroxysmal positional vertigo in patients with Meniere's disease. Gross, E.M., Ress, B.D., Viirre, E.S., Nelson, J.R., Harris, J.P. Laryngoscope (2000) [Pubmed]
  22. Particulate matter in the posterior semicircular canal. Welling, D.B., Parnes, L.S., O'Brien, B., Bakaletz, L.O., Brackmann, D.E., Hinojosa, R. Laryngoscope (1997) [Pubmed]
  23. Particle repositioning maneuver for benign paroxysmal positional vertigo. Welling, D.B., Barnes, D.E. Laryngoscope (1994) [Pubmed]
  24. Effect of mastoid oscillation on the outcome of the canalith repositioning procedure. Motamed, M., Osinubi, O., Cook, J.A. Laryngoscope (2004) [Pubmed]
  25. Mechanical versus CO2 laser occlusion of the posterior semicircular canal in humans. Antonelli, P.J., Lundy, L.B., Kartush, J.M., Burgio, D.L., Graham, M.D. The American journal of otology. (1996) [Pubmed]
  26. Benign paroxysmal positioning vertigo in multiple sclerosis: diagnosis, pathophysiology and therapeutic techniques. Frohman, E.M., Kramer, P.D., Dewey, R.B., Kramer, L., Frohman, T.C. Mult. Scler. (2003) [Pubmed]
  27. Success of the modified Epley maneuver in treating benign paroxysmal positional vertigo. Wolf, J.S., Boyev, K.P., Manokey, B.J., Mattox, D.E. Laryngoscope (1999) [Pubmed]
  28. Posterior semicircular canal occlusion for intractable benign paroxysmal positional vertigo. Parnes, L.S., McClure, J.A. The Annals of otology, rhinology, and laryngology. (1990) [Pubmed]
  29. Far advanced otosclerosis and intractable benign paroxysmal positional vertigo treated with combined cochlear implantation and posterior semicircular canal occlusion. Crossland, G., De, R., Axon, P. The Journal of laryngology and otology. (2004) [Pubmed]
  30. Exercise therapy for positional vertigo. Troost, B.T., Patton, J.M. Neurology (1992) [Pubmed]
  31. Benign paroxysmal positional vertigo of the horizontal canal. De la Meilleure, G., Dehaene, I., Depondt, M., Damman, W., Crevits, L., Vanhooren, G. J. Neurol. Neurosurg. Psychiatr. (1996) [Pubmed]
  32. Benign paroxysmal positional vertigo as a complication of postoperative bedrest. Gyo, K. Laryngoscope (1988) [Pubmed]
  33. Benign paroxysmal positional vertigo after stapedectomy. Atacan, E., Sennaroglu, L., Genc, A., Kaya, S. Laryngoscope (2001) [Pubmed]
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