Disease relevance of Multiple Chemical Sensitivity

• I was invited to speak to you as a patient--one who was poisoned by an organophosphate pesticide and who subsequently developed Multiple Chemical Sensitivity (MCS, or sometimes referred to as Environmental Illness, EI) [1].
• Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder [2].
• Carbonyl compounds (aldehydes and ketones) are suspected to be among the chemical compounds responsible for Sick Building Syndrome and Multiple Chemical Sensitivities [3].

High impact information on Multiple Chemical Sensitivity

• Paroxetine for multiple chemical sensitivity syndrome [4].
• OBJECTIVE: To assess the prevalence of and risk factors for self-reported symptoms suggestive of multiple chemical sensitivities/idiopathic environmental intolerance (MCS/IEI) in Persian Gulf War (PGW) veterans from Iowa and a comparison group of PGW-era military personnel [5].
• Idiopathic environmental intolerance: increased prevalence of panic disorder-associated cholecystokinin B receptor allele 7 [6].
• The panel assessed the quality of the existing epidemiologic literature on chlorpyrifos and specific outcomes such as neuropathy (including organophosphate induced delayed neurotoxicity), behavior (cognition and affect), immunologic, and multiple complaints (also referred to as multiple chemical sensitivities) [7].
• Panic response to sodium lactate infusion in patients with multiple chemical sensitivity syndrome [8].

Chemical compound and disease context of Multiple Chemical Sensitivity

• The elevated nitric oxide/peroxynitrite and the neural sensitization theories of multiple chemical sensitivity (MCS) are extended here to propose a central mechanism for the exquisite sensitivity to organic solvents apparently induced by previous chemical exposure in MCS [9].
• The literature on human caffeine discrimination provides a rigorous methodology that can address reports that patients who suffer multiple chemical sensitivity (MCS) are sensitive to usually well-tolerated chemical doses; the studies require patients to discriminate caffeine from placebo under double-blind conditions [10].
• Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-D-aspartate receptors in the sensitivity mechanism [9].
• The experience of the Yale Occupational and Environmental Medicine Clinics with multiple chemical sensitivities, 1986-1991 [11].
• Successful use of a selective serotonin reuptake inhibitor in a patient with multiple chemical sensitivities [12].

Biological context of Multiple Chemical Sensitivity

• We studied the change in the hypothalamo-pituitary-adrenal gland (HPA) axis upon adding prior toluene inhalation to our previous formaldehyde inhalation experiments to determine whether short term exposure to relatively high levels of toluene triggers multiple chemical sensitivity (MCS) [13].

Anatomical context of Multiple Chemical Sensitivity

• The vanilloid receptor (TRPV1 or VR1), widely distributed in the central and peripheral nervous system, is activated by a broad range of chemicals similar to those implicated in Multiple Chemical Sensitivity (MCS) Syndrome [14].

Gene context of Multiple Chemical Sensitivity

• The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity [14].
• Does the kindling model of epilepsy contribute to our understanding of multiple chemical sensitivity [15]?
• Report of Multiple Chemical Sensitivities (MCS) Workshop, Berlin, Germany, 21-23 February 1996. PCS/96.29 IPCS, Geneva, Switzerland [16].
• Idiopathic environmental intolerance: Part 1: A causation analysis applying Bradford Hill's criteria to the toxicogenic theory [17].
• Plasma levels of substance P, vasoactive intestinal peptide and nerve growth factor, but not histamine, were elevated in patients with self-reported multiple chemical sensitivity (sMCS) [18].

References