Disease relevance of Osteoblastoma

• Although the mean expression of PDGF-alpha receptor in osteoblastomas was much lower than in osteosarcomas (mean, 17.55%; range, 3.6 to 26.8%; SD, 6.47%), the difference was not significant (P = .122) [1].
• Prostaglandin synthesis by osteoid osteoma and osteoblastoma [2].
• Diffuse and strong COX-2 immunoreactivity was found in osteoblast-like tumor cells in the nidus of all six cases of OO (three of six cases were intraarticular OO associated with synovitis) and one case of osteoblastoma associated with synovitis [3].
• To assess the role and status of telomerase activity in benign bone tumors and tumor-like lesions, we performed telomerase assays in four giant cell tumors of bone, four fibrous dysplasias, three osteochondromas, three aneurysmal bone cysts, two osteoblastomas, one juvenile bone cyst and one myositis ossificans [4].
• The difference in CA-II immunoreactivity suggests the functional or maturational difference between osteoclast-like giant cells in GCT and chondroblastoma and those in osteoblastoma and osteosarcoma [5].

High impact information on Osteoblastoma

• The increased concentrations of prostaglandin E2 found in cases of osteoid osteoma and osteoblastoma confirm studies of explants of these tumors previously recorded in the literature [2].
• Similarly, evidence of osteonectin was also found in osteoblastic and in chondroblastic osteosarcomas as well as in osteoblastomas [6].
• Computed tomographic metrizamide myelography in the evaluation of thoracic spinal osteoblastoma [7].
• Enhancement of ornithine decarboxylase and Na+, K+ ATPase in osteoblastoma cells by intermittent compression [8].
• Fifty-seven osteosarcomas and 11 osteoblastomas as well as 5 bone specimens with remodeling sites were immunohistochemically analyzed for expression of OPN and VEGF [9].

Chemical compound and disease context of Osteoblastoma

• Pediatric case of the day. Osteoblastoma of the lateral mass of C6 on the right [10].
• An 8-year-old boy had an osteoblastoma of the body of C2 [11].
• Although non-contrast computed tomography and T1-weighted MRI are mildly positive in some instances, osteoblastoma is best visualized on MRI with gadolinium [12].

Anatomical context of Osteoblastoma

• A 14 year old boy with a relatively uncommon benign osteoblastoma of C5, C6 vertebrae presenting with wry neck is described with a brief review of literature [13].
• Unusual osteolytic midline lesion of the skull: benign osteoblastoma of the parietal bone [14].

Gene context of Osteoblastoma

• These were further classified with respect to CA-II immunoreactivity, i.e. cells with CA-II were seen in GCT and chondroblastoma, while those in osteoblastoma and osteoblastic osteosarcoma were negative for CA-II [5].
• Differentiation from osteogenic sarcoma is sometimes difficult even with histological material, because some low grade osteogenic sarcomas contain areas resembling osteoblastoma [15].
• Three cases of cementoblastoma (CB) and three cases of osteoblastoma (OB) were histologically compared [16].
• We performed instrumentation surgery on ten patients with the following rare primary spinal tumors; three solitary plasmacytomas, an aneurysmal bone cyst, a chordoma, a giant-cell tumor, a hemangioma, a solitary bone cyst, a benign osteoblastoma, and a chondrosarcoma [17].

References