Disease relevance of Hemangioma

• Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas [1].
• There was clear evidence of carcinogenicity in mice exposed to 400 ppm propylene oxide; 10 of 50 males and 5 of 50 females had hemangiomas or hemangiosarcomas of the nasal submucosa [2].
• Tsc2 heterozygotes display 100% incidence of multiple bilateral renal cystadenomas, 50% incidence of liver hemangiomas, and 32% incidence of lung adenomas by 15 months of age [3].
• In vivo, BV14 and BV13 were equally active in inhibiting angiogenesis in the mouse cornea and in reducing the growth of hemangioma and C6 glioma [4].
• In order to examine the role of HIF in von Hippel-Lindau (VHL)-associated vascular tumorigenesis, we utilized Cre-loxP-mediated recombination to inactivate hypoxia-inducible factor-1alpha (Hif-1alpha) and arylhydrocarbon receptor nuclear translocator (Arnt) genes in a VHL mouse model of cavernous liver hemangiomas and polycythemia [5].

Psychiatry related information on Hemangioma

• Infection of newborn or 2-week-old Src-negative mice with a retrovirus encoding middle T led to the induction of visceral hemangiomas that were indistinguishable from tumors in wild-type mice with respect to their morphology, frequency or latency period [6].
• The results concerning the association of HLA antigens with ITP, pernicious anaemia, hemangiomas and Alzheimer's disease are compared with those of other authors and the causes for differences are discussed [7].

High impact information on Hemangioma

• Images in clinical medicine. Congenital hemangioma [8].
• Treatment of vertebral hemangioma by intralesional injection of absolute ethanol [9].
• Transgene RNAs and protein are present in both hemangiomas and the testes of these mice, and the Py middle T protein in both tissues is complexed to a cellular tyrosine kinase [10].
• Evaluation of hemangiomas with technetium 99m-labeled RBCs. The perfusion-blood pool mismatch [11].
• By the same mechanism, tEnd.1 cells could induce NOS in the neighboring endothelial cells, and NO release could play a role in the hemangioma development [12].

Chemical compound and disease context of Hemangioma

• Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases [13].
• Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis [14].
• Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin [15].
• We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this possibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570] [16].
• Genes preferentially expressed in both placenta and hemangiomas were identified, including 17-beta hydroxysteroid dehydrogenase type 2 and tissue factor pathway inhibitor 2 [16].
• This is the first demonstration that human EPCs, isolated from blood or from a proliferating hemangioma, are stimulated by an angiogenesis inhibitor [17].

Biological context of Hemangioma

• Here, we have examined the role of PECAM-1 in regulation of bEND.3 cell proliferation, migration, morphogenesis, and hemangioma formation [18].
• Successful treatment of skeletal hemangioma and Kasabach-Merritt syndrome with aminocaproic acid. Is fibrinolysis "defensive" [19]?
• To determine whether hemangiomas represent a clonal expansion from a single progenitor cell, we assayed X-inactivation patterns for each lesion by using the polymorphic X-linked human androgen receptor gene [20].
• Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression [21].
• The resection of angioma in the first case resulted in improved visual acuity from counting fingers to 20/140, decreased exudates, and cessation of preoperative diffuse retinal capillary leakage observed by fluorescein angiography [22].

Anatomical context of Hemangioma

• In vivo, cidofovir (100 microg/egg) completely suppressed hemangioma formation on the chick chorioallantoic membrane (CAM) induced by intra-allantoic injection of FGF2-T-MAE cells, without affecting the formation of normal CAM vessels [23].
• Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma [24].
• In addition, staining for VEGFR-3 was strongly positive in the endothelium of cutaneous lymphangiomatosis, but staining of endothelial cells in cutaneous hemangiomas was weaker [25].
• The extracellular location of D3 gives ready access to circulating thyroid hormones, explaining its capacity for rapid inactivation of circulating thyroxine and triiodothyronine in patients with hemangiomas and its blockade of the access of maternal thyroid hormones to the human fetus [26].
• Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors [27].

Gene context of Hemangioma

• Heterozygous Tsc1 mutant (Tsc1(+/-)) mice developed renal and extra-renal tumors such as hepatic hemangiomas [28].
• In contrast, tamoxifen treatment for 9 months significantly reduced the frequency and severity of hemangiomas in Tsc1+/- female mice [29].
• Only one case of a juvenile hemangioma reached the cutoff value of p53 positivity coincidentally with high VEGF expression [30].
• These findings implicate Tie2 and its ligands Ang1 and Ang2 in the pathogenesis of hemangioma [31].
• Therefore, loss of imprinting is not involved in the increased expression of IGF2 in infantile hemangioma [21].

Analytical, diagnostic and therapeutic context of Hemangioma

• A case of hepatocellular carcinoma is presented that occurred two decades after radiotherapy for presumed hepatic hemangioma [32].
• Using DNA microarrays representing approximately 10,000 human genes, we identified insulin-like growth factor 2 (IGF-2) as a potentially important regulator of hemangioma growth [14].
• Except for six hemangioma nodules that were easily diagnosed only with angiography, four of 55 benign hepatic nodules (7.3%) showed false-positive findings suggestive of hepatocellular carcinoma with either computed tomographic arterioportography or enhanced ultrasonography [33].
• Northern blot analysis showed an overexpression of the TGF-beta1 gene in the hemangioma tissue, while normal control liver tissue expressed undetectable levels of TGF-beta1 messenger RNA [34].
• An S1 nuclease protection assay was used to measure thrombomodulin mRNA in hemangioma cells [35].

References