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MeSH Review


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Disease relevance of Hemangioma


Psychiatry related information on Hemangioma

  • Infection of newborn or 2-week-old Src-negative mice with a retrovirus encoding middle T led to the induction of visceral hemangiomas that were indistinguishable from tumors in wild-type mice with respect to their morphology, frequency or latency period [6].
  • The results concerning the association of HLA antigens with ITP, pernicious anaemia, hemangiomas and Alzheimer's disease are compared with those of other authors and the causes for differences are discussed [7].

High impact information on Hemangioma


Chemical compound and disease context of Hemangioma


Biological context of Hemangioma


Anatomical context of Hemangioma


Gene context of Hemangioma

  • Heterozygous Tsc1 mutant (Tsc1(+/-)) mice developed renal and extra-renal tumors such as hepatic hemangiomas [28].
  • In contrast, tamoxifen treatment for 9 months significantly reduced the frequency and severity of hemangiomas in Tsc1+/- female mice [29].
  • Only one case of a juvenile hemangioma reached the cutoff value of p53 positivity coincidentally with high VEGF expression [30].
  • These findings implicate Tie2 and its ligands Ang1 and Ang2 in the pathogenesis of hemangioma [31].
  • Therefore, loss of imprinting is not involved in the increased expression of IGF2 in infantile hemangioma [21].

Analytical, diagnostic and therapeutic context of Hemangioma


  1. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. Huang, S.A., Tu, H.M., Harney, J.W., Venihaki, M., Butte, A.J., Kozakewich, H.P., Fishman, S.J., Larsen, P.R. N. Engl. J. Med. (2000) [Pubmed]
  2. Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling propylene oxide for up to two years. Renne, R.A., Giddens, W.E., Boorman, G.A., Kovatch, R., Haseman, J.E., Clarke, W.J. J. Natl. Cancer Inst. (1986) [Pubmed]
  3. Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. Onda, H., Lueck, A., Marks, P.W., Warren, H.B., Kwiatkowski, D.J. J. Clin. Invest. (1999) [Pubmed]
  4. A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Corada, M., Zanetta, L., Orsenigo, F., Breviario, F., Lampugnani, M.G., Bernasconi, S., Liao, F., Hicklin, D.J., Bohlen, P., Dejana, E. Blood (2002) [Pubmed]
  5. Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Rankin, E.B., Higgins, D.F., Walisser, J.A., Johnson, R.S., Bradfield, C.A., Haase, V.H. Mol. Cell. Biol. (2005) [Pubmed]
  6. Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. Thomas, J.E., Aguzzi, A., Soriano, P., Wagner, E.F., Brugge, J.S. Oncogene (1993) [Pubmed]
  7. Some critical remarks on the problem of HLA association with disease. Májský, A., Korínková, P., Fortýnová, J., Abrahámová, J., Vojtĕchovský, M. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. (1981) [Pubmed]
  8. Images in clinical medicine. Congenital hemangioma. Bonifazi, E., Mileti, F. N. Engl. J. Med. (1999) [Pubmed]
  9. Treatment of vertebral hemangioma by intralesional injection of absolute ethanol. Heiss, J.D., Doppman, J.L., Oldfield, E.H. N. Engl. J. Med. (1996) [Pubmed]
  10. Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene. Bautch, V.L., Toda, S., Hassell, J.A., Hanahan, D. Cell (1987) [Pubmed]
  11. Evaluation of hemangiomas with technetium 99m-labeled RBCs. The perfusion-blood pool mismatch. Front, D., Israel, O., Joachims, H., Brown, Y., Eliachar, I. JAMA (1983) [Pubmed]
  12. Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase. Ghigo, D., Arese, M., Todde, R., Vecchi, A., Silvagno, F., Costamagna, C., Dong, Q.G., Alessio, M., Heller, R., Soldi, R., Trucco, F., Garbarino, G., Pescarmona, G., Mantovani, A., Bussolino, F., Bosia, A. J. Exp. Med. (1995) [Pubmed]
  13. Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases. Taraboletti, G., Garofalo, A., Belotti, D., Drudis, T., Borsotti, P., Scanziani, E., Brown, P.D., Giavazzi, R. J. Natl. Cancer Inst. (1995) [Pubmed]
  14. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Ritter, M.R., Dorrell, M.I., Edmonds, J., Friedlander, S.F., Friedlander, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Transcription of thrombomodulin mRNA in mouse hemangioma cells is increased by cycloheximide and thrombin. Dittman, W.A., Kumada, T., Majerus, P.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  16. Evidence by molecular profiling for a placental origin of infantile hemangioma. Barnés, C.M., Huang, S., Kaipainen, A., Sanoudou, D., Chen, E.J., Eichler, G.S., Guo, Y., Yu, Y., Ingber, D.E., Mulliken, J.B., Beggs, A.H., Folkman, J., Fishman, S.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  17. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Khan, Z.A., Melero-Martin, J.M., Wu, X., Paruchuri, S., Boscolo, E., Mulliken, J.B., Bischoff, J. Blood (2006) [Pubmed]
  18. Down-regulation of platelet endothelial cell adhesion molecule-1 results in thrombospondin-1 expression and concerted regulation of endothelial cell phenotype. Sheibani, N., Frazier, W.A. Mol. Biol. Cell (1998) [Pubmed]
  19. Successful treatment of skeletal hemangioma and Kasabach-Merritt syndrome with aminocaproic acid. Is fibrinolysis "defensive"? Neidhart, J.A., Roach, R.W. Am. J. Med. (1982) [Pubmed]
  20. Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. Walter, J.W., North, P.E., Waner, M., Mizeracki, A., Blei, F., Walker, J.W., Reinisch, J.F., Marchuk, D.A. Genes Chromosomes Cancer (2002) [Pubmed]
  21. Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression. Yu, Y., Wylie-Sears, J., Boscolo, E., Mulliken, J.B., Bischoff, J. Mol. Med. (2004) [Pubmed]
  22. Treatment of large von Hippel tumors by eye wall resection. Peyman, G.A., Rednam, K.R., Mottow-Lippa, L., Flood, T. Ophthalmology (1983) [Pubmed]
  23. Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir. Liekens, S., Neyts, J., De Clercq, E., Verbeken, E., Ribatti, D., Presta, M. Cancer Res. (2001) [Pubmed]
  24. Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma. Qu, Z., Liebler, J.M., Powers, M.R., Galey, T., Ahmadi, P., Huang, X.N., Ansel, J.C., Butterfield, J.H., Planck, S.R., Rosenbaum, J.T. Am. J. Pathol. (1995) [Pubmed]
  25. Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors. Lymboussaki, A., Partanen, T.A., Olofsson, B., Thomas-Crusells, J., Fletcher, C.D., de Waal, R.M., Kaipainen, A., Alitalo, K. Am. J. Pathol. (1998) [Pubmed]
  26. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. Baqui, M., Botero, D., Gereben, B., Curcio, C., Harney, J.W., Salvatore, D., Sorimachi, K., Larsen, P.R., Bianco, A.C. J. Biol. Chem. (2003) [Pubmed]
  27. Urokinase-type plasminogen activator gene regulation by polyomavirus middle-T antigen. Besser, D., Urich, M., Sakaue, M., Messerschmitt, A., Ballmer-Hofer, K., Nagamine, Y. Oncogene (1995) [Pubmed]
  28. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Kobayashi, T., Minowa, O., Sugitani, Y., Takai, S., Mitani, H., Kobayashi, E., Noda, T., Hino, O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Estrogen enhances whereas tamoxifen retards development of Tsc mouse liver hemangioma: a tumor related to renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. El-Hashemite, N., Walker, V., Kwiatkowski, D.J. Cancer Res. (2005) [Pubmed]
  30. MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Zietz, C., Rössle, M., Haas, C., Sendelhofert, A., Hirschmann, A., Stürzl, M., Löhrs, U. Am. J. Pathol. (1998) [Pubmed]
  31. Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Yu, Y., Varughese, J., Brown, L.F., Mulliken, J.B., Bischoff, J. Am. J. Pathol. (2001) [Pubmed]
  32. Hepatoma occurring two decades after hepatic irradiation. Moore, T.A., Ferrante, W.A., Crowson, T.D. Gastroenterology (1976) [Pubmed]
  33. Imaging diagnosis of small hepatocellular carcinoma. Ikeda, K., Saitoh, S., Koida, I., Tsubota, A., Arase, Y., Chayama, K., Kumada, H. Hepatology (1994) [Pubmed]
  34. Increased circulating transforming growth factor beta1 in a patient with giant hepatic hemangioma: possible contribution to an impaired immune function. Ito, N., Kawata, S., Tsushima, H., Tamura, S., Kiso, S., Takami, S., Igura, T., Monnden, M., Matsuzawa, Y. Hepatology (1997) [Pubmed]
  35. The structure and function of mouse thrombomodulin. Phorbol myristate acetate stimulates degradation and synthesis of thrombomodulin without affecting mRNA levels in hemangioma cells. Dittman, W.A., Kumada, T., Sadler, J.E., Majerus, P.W. J. Biol. Chem. (1988) [Pubmed]
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