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ANBC  -  Aneurysmal bone cysts

Homo sapiens

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Disease relevance of ANBC


High impact information on ANBC

  • Aneurysmal bone cysts (ABC) are locally aggressive bone tumors that often feature chromosome 17p13 rearrangements [5].
  • Herein, we characterize four different ABC translocations involving 17p13, and we show that each is associated with a novel USP6 fusion oncogene [5].
  • MATERIALS AND METHODS: The authors retrospectively analyzed all cases of ABCs treated with direct fibrosing agent injection (Ethibloc; Ethnor Laboratories, Ethicon, Noderstedt, Germany) at Robert Debré Hospital since 1994 [6].
  • Among benign lesions, only 2 aneurysmal bone cysts showed higher telomerase activity than the cut-off point, whereas all the other benign lesions had lower activity [7].
  • Cytogenetic findings in aneurysmal bone cysts [8].

Chemical compound and disease context of ANBC

  • Human bones were partially decalcified using 0.6 N HCl and preserved in 90% ethanol in a deep freezer at -16 degrees C. The cystic lesions were: 5 cases of fibrous dysplasia, 4 aneurysmal bone cysts, 3 simple bone cysts, 2 giant-cell tumours, 1 chondromyxoid fibroma, 1 non-ossifying fibroma and 1 fibrous cortical defect [9].

Biological context of ANBC


Anatomical context of ANBC


Associations of ANBC with chemical compounds


Other interactions of ANBC


Analytical, diagnostic and therapeutic context of ANBC


  1. Fluid-fluid level: a nonspecific finding in tumors of bone and soft tissue. Tsai, J.C., Dalinka, M.K., Fallon, M.D., Zlatkin, M.B., Kressel, H.Y. Radiology. (1990) [Pubmed]
  2. Cytogenetic and molecular cytogenetic findings in 43 aneurysmal bone cysts: aberrations of 17p mapped to 17p13.2 by fluorescence in situ hybridization. Althof, P.A., Ohmori, K., Zhou, M., Bailey, J.M., Bridge, R.S., Nelson, M., Neff, J.R., Bridge, J.A. Mod. Pathol. (2004) [Pubmed]
  3. Megavoltage radiotherapy for aneurysmal bone cysts. Feigenberg, S.J., Marcus, R.B., Zlotecki, R.A., Scarborough, M.T., Berrey, B.H., Enneking, W.F. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  4. Fluid-fluid levels in benign neurogenic tumors. Catalano, P., Fang-Hui, E., Som, P.M. AJNR. American journal of neuroradiology. (1997) [Pubmed]
  5. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oliveira, A.M., Perez-Atayde, A.R., Dal Cin, P., Gebhardt, M.C., Chen, C.J., Neff, J.R., Demetri, G.D., Rosenberg, A.E., Bridge, J.A., Fletcher, J.A. Oncogene (2005) [Pubmed]
  6. Aneurysmal bone cysts in children: complications of fibrosing agent injection. Topouchian, V., Mazda, K., Hamze, B., Laredo, J.D., Penneçot, G.F. Radiology. (2004) [Pubmed]
  7. Presence of telomerase activity in different musculoskeletal tumor histotypes and correlation with aggressiveness. Sangiorgi, L., Gobbi, G.A., Lucarelli, E., Sartorio, S.M., Mordenti, M., Ghedini, I., Maini, V., Scrimieri, F., Reggiani, M., Bertoja, A.Z., Benassi, M.S., Picci, P. Int. J. Cancer (2001) [Pubmed]
  8. Cytogenetic findings in aneurysmal bone cysts. Pfeifer, F.M., Bridge, J.A., Neff, J.R., Mouron, B.J. Genes Chromosomes Cancer (1991) [Pubmed]
  9. Allograft in the treatment of benign cystic lesions of bone. Sethi, A., Agarwal, K., Sethi, S., Kumar, S., Marya, S.K., Tuli, S.M. Archives of orthopaedic and trauma surgery. (1993) [Pubmed]
  10. Cranial aneurysmal bone cysts presenting with raised intracranial pressure: report of two cases. Chateil, J.F., Dousset, V., Meyer, P., Pedespan, J.M., San-Galli, F., Rivel, J., Caillé, J.M., Diard, F. Neuroradiology. (1997) [Pubmed]
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  12. Demineralized bone implants for nonunion fractures, bone cysts, and fibrous lesions. Rosenthal, R.K., Folkman, J., Glowacki, J. Clin. Orthop. Relat. Res. (1999) [Pubmed]
  13. Aneurysmal bone cyst of the maxilla--an association with tooth resorption. Hardee, P.S., Whear, N.M., Morgan, P.R. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (1992) [Pubmed]
  14. Treatment of aneurysmal bone cysts of the pelvis and sacrum. Papagelopoulos, P.J., Choudhury, S.N., Frassica, F.J., Bond, J.R., Unni, K.K., Sim, F.H. The Journal of bone and joint surgery. American volume. (2001) [Pubmed]
  15. Treatment of aneurysmal bone cysts by introduction of demineralized bone and autogenous bone marrow. Docquier, P.L., Delloye, C. The Journal of bone and joint surgery. American volume. (2005) [Pubmed]
  16. Vertebra plana due to an aneurysmal bone cyst of the lumbar spine. Case report and review of the literature. Codd, P.J., Riesenburger, R.I., Klimo, P., Slotkin, J.R., Smith, E.R. J. Neurosurg. (2006) [Pubmed]
  17. Aneurysmal bone cyst of the odontoid process: case report. Andersen, B.J., Goldhagen, P., Cahill, D.W. Neurosurgery (1991) [Pubmed]
  18. Endothelium in aneurysmal bone cyst. Aho, H.J., Aho, A.J., Pelliniemi, L.J., Ekfors, T.O., Foidart, J.M. Histopathology (1985) [Pubmed]
  19. Immunocytochemical markers (endothelial and histiocytic) and ultrastructure of primary aneurysmal bone cysts. Alles, J.U., Schulz, A. Hum. Pathol. (1986) [Pubmed]
  20. Treatment of aneurysmal bone cysts with percutaneous sclerotherapy using polidocanol: A REVIEW OF 72 CASES WITH LONG-TERM FOLLOW-UP. Rastogi, S., Varshney, M.K., Trikha, V., Khan, S.A., Choudhury, B., Safaya, R. The Journal of bone and joint surgery. British volume. (2006) [Pubmed]
  21. Sclerotherapy in aneurysmal bone cysts in children: a review of 17 cases. Dubois, J., Chigot, V., Grimard, G., Isler, M., Garel, L. Pediatric radiology. (2003) [Pubmed]
  22. Aneurysmal bone cyst of the spine in children. MRI imaging at 0.5 tesla. Caro, P.A., Mandell, G.A., Stanton, R.P. Pediatric radiology. (1991) [Pubmed]
  23. Giant cell reparative granuloma presenting as a midline nasal mass. Govett, G.S., Amedee, R.G. Ear, nose, & throat journal. (1991) [Pubmed]
  24. Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts. de Silva, M.V., Raby, N., Reid, R. Histopathology (2003) [Pubmed]
  25. Juxtaphyseal aneurysmal bone cysts. Rizzo, M., Dellaero, D.T., Harrelson, J.M., Scully, S.P. Clin. Orthop. Relat. Res. (1999) [Pubmed]
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