Disease relevance of Adenoma, Chromophobe

• A total of 349 patients with pituitary tumors, including acromegaly, Cushing disease, Nelson syndrome, prolactin-secreting adenoma, and chromophobe adenoma, have been treated with heavy-particle radiation during the past 17 years [1].
• One patient developed inappropriate antidiuretic hormone secretion with spontaneous infarction in a large but clinically silent chromophobe adenoma [2].
• SSTR5 mRNA was not expressed in four human pituitary tumors (somatotroph adenoma, prolactinoma, and chromophobe adenomas) or in a human insulinoma [3].
• Morphometric analysis of secretory granules was performed in 16 chromophobe adenomas: seven undifferentiated cell adenomas (group A), two of which were accompanied by mild hyperprolactinemia and nine prolactin cell sparsely granulated adenomas (group B), all associated with hyperprolactinemia [4].
• Elevated mean GH and PRL levels in serum and in CSF were found in patients with chromophobe adenomas and with acromegaly [5].

High impact information on Adenoma, Chromophobe

• Isolated hypersecretion of the alpha subunit of the glycoprotein hormones occurred in two men with previously diagnosed "nonfunctioning chromophobe adenomas." The alpha hypersecretion was unresponsive to hypothalamic releasing hormone, thyroid hormone, and sex-steroid hormones [6].
• In contrast, non-PRL-secreting chromophobe adenomas are devoid of specific binding [7].
• The light microscopical, electron microscopical and immunohistological features of a rare ACTH-producing chromophobe adenoma of the pituitary gland in an 11-month-old infant are presented [8].
• Hypophysectomy because of a functionless chromophobe adenoma resulted in a significantly lower maximum value of LH but not of FSH after LHRH [9].
• A patient with a surgically treated chromophobe adenoma showed no change in parameters measured before and after clomiphene administration [10].

Chemical compound and disease context of Adenoma, Chromophobe

• At surgery, we found a large chromophobe adenoma with few PAS-positive granules and with immunostaining positive for TSH and prolactin [11].
• Thioridazine was found to increase the serum prolactin level as well as the tumor size of a prolactin--secreting pituitary chromophobe adenoma in a schizophrenic man [12].
• Hematoxylin and eosin-stained sections were consistent with a chromophobe adenoma [13].
• In order to study the light microscopical alterations of pituitary tumours under dopamine agonist treatment, three groups of a total of 18 large or small cell chromophobe adenomas were analysed by light microscopical, immunohistological and morphometrical methods [14].
• 14C-Nicotinic acid (NA) incorporation into nicotinamide adenine dinucleotide (NAD) was studied in cultures from 7 normal human pituitaries and 13 chromophobe adenomas [15].

Anatomical context of Adenoma, Chromophobe

• A man with normal-sizes testes and a chromophobe adenoma of the pituitary was found to have elevated plasma levels of FSH and prolactin and severe deficiencies of other trophic hormones [16].

Gene context of Adenoma, Chromophobe

• 36 pituitary tumours have been explanted to in vitro culture: 20 tumours causing acromegaly, 9 porlactinomas, 2 ACTH-producing and 5 chromophobe adenomas [17].

Analytical, diagnostic and therapeutic context of Adenoma, Chromophobe

• In another case whose PRL was normal over 17.5 h, transsphenoidal surgery, carried out because of the tomographic findings and the symptom of headaches, demonstrated a 5-mm chromophobe adenoma that did not contain PRL by immunohistochemistry [18].
• In order to identify prolactin-producing tumours in human pituitary glands, 45 chromophobe adenomas, obtained from unselected necropsies, have been studied by various staining procedures including the immunoperoxidase technique for the demonstration of prolactin [19].

References