Disease relevance of Autonomic Denervation

• Cardiac autonomic denervation in congestive heart failure: comparison of Chagas' heart disease with other dilated cardiomyopathy [1].
• Ocular autonomic nerve function was assessed in 28 diabetic patients with proliferative retinopathy (PDR) and 61 age- and sex-matched control subjects, by measurement of the pupil cycle time and determination of autonomic denervation hypersensitivity of the iris [2].
• CONCLUSIONS: Extrinsic autonomic denervation of the jejunoileum, with or without synchronous ischemia-reperfusion, results in increased cholesterol synthesis, bile acid malabsorption, and decreased weight gain [3].

High impact information on Autonomic Denervation

• Acetylcholine sweatspot test for autonomic denervation [4].
• Only 3 days of complete AV block and autonomic denervation did not affect the prolongation of V-ERP produced by rapid pacing, whereas verapamil significantly blunted but did not eliminate the prolongation [5].
• Augmented sympathetic response to bradykinin in the diabetic heart before autonomic denervation [6].
• Autonomic denervation was achieved by the application of chlorisondamine [7].
• Evaluation of topical phenol as a means of producing autonomic denervation of the liver [8].

Biological context of Autonomic Denervation

• Cardiac autonomic denervation did not modify the tiapamil-induced decrease in coronary vascular resistance and did not cause tiapamil to display negative inotropism [9].

Associations of Autonomic Denervation with chemical compounds

• METHODS: Sixteen pigs with similar food, cholesterol, and fat intake underwent either sham laparotomy or a model of jejunoileal autotransplantation, including extrinsic autonomic denervation, lymphatic interruption, and in situ cold ischemia [10].
• Dexmedetomidine (DM) has been found to depress cardiac function in dogs, even after autonomic denervation [11].
• Norepinephrine content of myocardial bioptic specimens was about threefold lower than normal, indicating that autonomic denervation may contribute to the maintenance and progression of cardiomyopathy [12].

References