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Chemical Compound Review

Tiapamil     N-[2-(3,4- dimethoxyphenyl)ethyl]-3-[2- (3,4...

Synonyms: Tiapamilo, Tiapamilum, CHEMBL125737, CHEBI:309484, CTK1H0619, ...
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Disease relevance of Tiapamil hydrochloride


High impact information on Tiapamil hydrochloride


Chemical compound and disease context of Tiapamil hydrochloride


Biological context of Tiapamil hydrochloride


Anatomical context of Tiapamil hydrochloride


Associations of Tiapamil hydrochloride with other chemical compounds


Gene context of Tiapamil hydrochloride

  • Tiapamil led to a decrease in mean daytime systolic (SBP) and diastolic (DBP) BP from 171 +/- 12/98 +/- 10 mm Hg to 159 +/- 11/90 +/- 9 mm Hg (P less than 0.001) without significant variation in HR [21].

Analytical, diagnostic and therapeutic context of Tiapamil hydrochloride


  1. Tiapamil, a new calcium antagonist: hemodynamic effects in patients with acute myocardial infarction. Eichler, H.G., Mabin, T.A., Commerford, P.J., Lloyd, E.A., Beck, W., Opie, L.H. Circulation (1985) [Pubmed]
  2. Verapamil and tiapamil in prevention of ventricular fibrillation in pigs with coronary ligation. Comparative effects on left ventricular function. Muller, C.A., Opie, L.H., Hamm, C.W., Peisach, M., Pineda, C.A., Thandroyen, F.T. Circulation (1988) [Pubmed]
  3. Effect of i.v. and oral tiapamil in the treatment of paroxysmal supraventricular tachycardia. Fauchier, J.P., Elkik, F., Cosnay, P., Rouesnel, P., Neel, C., Quillet, L. Eur. Heart J. (1985) [Pubmed]
  4. Efficacy of incremental doses of tiapamil on exercise performance in patients with chronic stable angina pectoris. O'Keefe, J.C., Maltz, M.B., Butrous, G.S., Camm, A.J. Eur. Heart J. (1986) [Pubmed]
  5. Effect of calcium antagonists on basal and digitalis-dependent changes in splanchnic and systemic hemodynamics. Gasić, S., Eichler, H.G., Korn, A. Clin. Pharmacol. Ther. (1987) [Pubmed]
  6. Effects of the calcium antagonist tiapamil on pulmonary gas exchange in patients with chronic obstructive pulmonary disease who receive salbutamol. Gugger, M., Crivelli, A.M., Galeazzi, R.L., Bachofen, H. Clin. Pharmacol. Ther. (1985) [Pubmed]
  7. Comparative effects of prolonged therapy with four calcium ion antagonists (diltiazem, nicardipine, tiapamil and verapamil) in patients with chronic stable angina pectoris. Khurmi, N.S., Raftery, E.B. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1987) [Pubmed]
  8. Effect of tiapamil and nifedepine during critical coronary stenosis and in the presence of adrenergic beta-receptor blockade in anesthetized dogs. Saini, R.K., Fulmor, I.E., Antonaccio, M.J. J. Cardiovasc. Pharmacol. (1982) [Pubmed]
  9. Chronic hemodynamic effects of tiapamil and felodipine in essential hypertension at rest and during exercise. Lund-Johansen, P., Omvik, P. J. Cardiovasc. Pharmacol. (1990) [Pubmed]
  10. Comparative acute effects of the calcium channel blockers tiapamil, nisoldipine, and nifedipine on blood pressure and some regulatory factors in normal and hypertensive subjects. Laederach, K., Weidmann, P., Lauener, F., Gerber, A., Ziegler, W.H. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
  11. Bioelectrical and mechanical effects of tiapamil (Ro 11-1781) on isolated guinea pig myocardium. Späh, F. Cardiovasc. Res. (1986) [Pubmed]
  12. Antiarrhythmic and haemodynamic effects of tiapamil, a new calcium antagonist, during coronary artery occlusion and reperfusion in dogs. Shargorodsky, B.M., Braun, S., Belhassen, B., Laniado, S. Cardiovasc. Res. (1986) [Pubmed]
  13. Temperature-dependent regulation of d-cis-[3H]diltiazem binding to Ca2+ channels by 1,4-dihydropyridine channel agonists and antagonists. Glossmann, H., Linn, T., Rombusch, M., Ferry, D.R. FEBS Lett. (1983) [Pubmed]
  14. Interaction between digoxin and the calcium antagonists nicardipine and tiapamil. Lessem, J., Bellinetto, A. Clinical therapeutics. (1983) [Pubmed]
  15. [3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes. Sarmiento, J.G., Shrikhande, A.V., Janis, R.A., Triggle, D.J. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  16. Excretion of tiapamil in breast milk. Hartmann, D., Lunell, N.O., Friedrich, G., Rane, A. British journal of clinical pharmacology. (1988) [Pubmed]
  17. Tiapamil reduces the calcium inward current of isolated smooth muscle cells. Dependence on holding potential and pulse frequency. Klöckner, U., Isenberg, G. Eur. J. Pharmacol. (1986) [Pubmed]
  18. Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. Campain, J.A., Padmanabhan, R., Hwang, J., Gottesman, M.M., Pastan, I. J. Cell. Physiol. (1993) [Pubmed]
  19. Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro. Eliason, J.F., Ramuz, H., Yoshikubo, T., Ishikawa, T., Yamamoto, T., Tsuruo, T. Biochem. Pharmacol. (1995) [Pubmed]
  20. The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo. Eliason, J.F., Sawada, R., Tsukaguchi, T., Kobayashi, K., Ichihara, S., Konishi, C., Horii, I., Kuruma, I., Ramuz, H. Eur. J. Cancer (1995) [Pubmed]
  21. Effect of a new calcium antagonist, tiapamil, in hypertension of the elderly. Balansard, P., Elkik, F., Levenson, J.A., Ciampi, M., Sans, P. British journal of clinical pharmacology. (1984) [Pubmed]
  22. Mechanisms involved in reperfusion arrhythmias. Verrier, R.L., Hagestad, E.L. Eur. Heart J. (1986) [Pubmed]
  23. Determination of tiapamil and of its two main metabolites in plasma and in urine by high-performance liquid chromatography. Heizmann, P., Wendt, G., Von Alten, R., Zinapold, K., Buser, C. J. Chromatogr. (1984) [Pubmed]
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