The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Ecolid     trimethyl-[2-(4,5,6,7- tetrachloro-2-methyl...

Synonyms: Hisindamone A, Ecolid R, AG-J-54060, CHEMBL2104531, LS-84731, ...
This record was replaced with 6244.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tocris-1001


Psychiatry related information on Tocris-1001

  • When exposed to the social interaction test, neither restraint nor chlorisondamine affected social interaction, locomotion, or rearings [5].
  • When chlorisondamine was used as a ganglionic blocker (2.5, IV), the fall in CVP at 10 mm Hg negative pressure was greater for the NT group while the fall in the initial systemic arterial pressure was more for the T group [6].
  • Inhibition of the protein synthesis had no effect, ganglionic blockade by chlorisondamine on the other hand abolished the rhythm in the motor activity, subacute treatment with reserpine differently affected motor activity in both photo-periods, depending on the time of drug application within 24 hr of a day [7].

High impact information on Tocris-1001


Chemical compound and disease context of Tocris-1001


Biological context of Tocris-1001

  • Direct nicotinic stimulation of chromaffin cells caused catecholamine release and transgene transcription, each of which was nearly completely blocked by chlorisondamine [12].
  • After pretreatment with chlorisondamine (5 mg/kg IP) or prazosin (5 mg/kg IP) to inhibit autonomic ganglionic or alpha 1-adrenoceptor functions, respectively, ZnDPBG did not affect arterial pressure or heart rate [18].
  • Whereas the antagonists dihydro-beta-erythroidine (IC50 of 3-6 nM) and methyllycaconitine (IC50 of 40-135 nM) were not selective between high- and low-sensitivity alpha4beta2, chlorisondamine, mecamylamine, and d-tubocurarine were, respectively, 100-, 8-, and 5-fold selective for the alpha4beta2 subform with low sensitivity to acetylcholine [19].
  • Ganglionic blockade (chlorisondamine 2 mg/kg i.v.) diminished mean arterial responses without altering peptide effects on renal circulation [20].
  • As before, this up-regulation was neither mimicked nor blocked by chlorisondamine pretreatment (10 mg kg-1, s.c., given twice), despite persistent blockade of acute locomotor responses to nicotine.(ABSTRACT TRUNCATED AT 250 WORDS)[21]

Anatomical context of Tocris-1001


Associations of Tocris-1001 with other chemical compounds


Gene context of Tocris-1001

  • CRF inhibited the evoked response of these units in a dose-dependent manner with an ED50 of 2.3-7 nmol/kg i.v. Neither naloxone nor chlorisondamine pretreatment prevented the inhibitory actions of CRF [32].
  • Pretreatment with chlorisondamine, a ganglionic blocking agent, inhibited the Il-6 responses, while it had little influence on the TNF responses [33].
  • Chlorisondamine, administered at a dose which completely blocks ganglion transmission, blocked the increase in TH activity [34].
  • Blockade of the sympathetic transmission by chlorisondamine prevented the inhibitory effect of morphine on TNF-alpha production [35].
  • The suppressive effect of urocortin was abolished by pretreatment with a ganglionic blocking agent (chlorisondamine) or a beta-adrenergic receptor antagonist (propranolol), but not by adrenalectomy [36].

Analytical, diagnostic and therapeutic context of Tocris-1001


  1. Reflex splanchnic nerve stimulation increases levels of proenkephalin A mRNA and proenkephalin A-related peptides in the rat adrenal medulla. Kanamatsu, T., Unsworth, C.D., Diliberto, E.J., Viveros, O.H., Hong, J.S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Vasopressin contributes to hypertension caused by nucleus tractus solitarius lesions. Sved, A.F., Imaizumi, T., Talman, W.T., Reis, D.J. Hypertension (1985) [Pubmed]
  3. Air jet noise exposure rapidly increases blood pressure in young borderline hypertensive rats. Fisher, L.D., Tucker, D.C. J. Hypertens. (1991) [Pubmed]
  4. Effects of nicotinic antagonists on ocular growth and experimental myopia. Stone, R.A., Sugimoto, R., Gill, A.S., Liu, J., Capehart, C., Lindstrom, J.M. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  5. Effects of chlorisondamine and restraint on cortical [3H]ketanserin binding, 5-HT2A receptor-mediated head shakes, and behaviours in models of anxiety. Chaouloff, F., Baudrie, V., Coupry, I. Neuropharmacology (1994) [Pubmed]
  6. Blood pressure responses to LBNP in nontrained and trained hypertensive rats. Bedford, T.G., Tipton, C.M. Medicine and science in sports and exercise. (1992) [Pubmed]
  7. Diurnal rhythms in noradrenaline turnover and motility after reserpine and 6-hydroxydopamine. Lemmer, B., Wenda, K. Pharmacol. Biochem. Behav. (1979) [Pubmed]
  8. Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Rivier, C., Vale, W. Nature (1983) [Pubmed]
  9. Hypotensive effect of clonidine during sodium depletion in the rat. Pals, D.T. Circ. Res. (1975) [Pubmed]
  10. Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor. Sundar, S.K., Cierpial, M.A., Kilts, C., Ritchie, J.C., Weiss, J.M. J. Neurosci. (1990) [Pubmed]
  11. Plasticity of expression of a synaptic vesicle antigen in adult rat superior cervical ganglion. Greif, K.F. J. Neurosci. (1986) [Pubmed]
  12. Catecholamine secretory vesicle stimulus-transcription coupling in vivo. Demonstration by a novel transgenic promoter/photoprotein reporter and inhibition of secretion and transcription by the chromogranin A fragment catestatin. Mahata, S.K., Mahapatra, N.R., Mahata, M., Wang, T.C., Kennedy, B.P., Ziegler, M.G., O'Connor, D.T. J. Biol. Chem. (2003) [Pubmed]
  13. Effects of alpha adrenergic blockade, combined nicotinic and muscarinic ganglion blockade and spinal anesthesia upon norepinephrine depression of ganglion transmission in the dog. Hilton, J.G. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  14. Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. Prokocimer, P.G., Maze, M., Hoffman, B.B. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  15. Centrally mediated drug-induced hyperglycemia in mice. Wannarka, G.L., Fletcher, H.P., Maickel, R.P. Neuropharmacology (1983) [Pubmed]
  16. New evidence for neuronal function of vasopressin: sympathetic mediation of intrathecal vasopressin-induced hypertension. Tan, D.P., Tsou, K. Peptides (1986) [Pubmed]
  17. Hemodynamic actions of systemically injected pituitary adenylate cyclase activating polypeptide-27 in the rat. Whalen, E.J., Johnson, A.K., Lewis, S.J. Eur. J. Pharmacol. (1999) [Pubmed]
  18. A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats. Johnson, R.A., Lavesa, M., Askari, B., Abraham, N.G., Nasjletti, A. Hypertension (1995) [Pubmed]
  19. Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors. Briggs, C.A., Gubbins, E.J., Marks, M.J., Putman, C.B., Thimmapaya, R., Meyer, M.D., Surowy, C.S. Mol. Pharmacol. (2006) [Pubmed]
  20. Regional blood flows and cardiac function changes induced by angiotensin II in conscious dogs. Doursout, M.F., Chelly, J.E., Hartley, C.J., Szilagyi, J., Montastruc, J.L., Buckley, J.P. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  21. Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. el-Bizri, H., Clarke, P.B. Br. J. Pharmacol. (1994) [Pubmed]
  22. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. Wang, J., Charboneau, R., Balasubramanian, S., Barke, R.A., Loh, H.H., Roy, S. J. Leukoc. Biol. (2002) [Pubmed]
  23. Effects of stress on alveolar macrophages: a role for the sympathetic nervous system. Broug-Holub, E., Persoons, J.H., Schornagel, K., Mastbergen, S.C., Kraal, G. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  24. Mechanisms of gastric acid secretion after pylorus and oesophagus ligation in the rat. Håkanson, R., Hedenbro, J., Liedberg, G., Sundler, F., Vallgren, S. J. Physiol. (Lond.) (1980) [Pubmed]
  25. Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine administered in vivo. el-Bizri, H., Clarke, P.B. Br. J. Pharmacol. (1994) [Pubmed]
  26. beta-Endorphin-induced stimulation of central sympathetic outflow: inhibitory modulation by central noradrenergic neurons. Appel, N.M., Van Loon, G.R. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  27. Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat. Lenz, H.J., Burlage, M., Raedler, A., Greten, H. Gastroenterology (1988) [Pubmed]
  28. Corticotropin-releasing factor: long-lasting facilitation of the acoustic startle reflex. Liang, K.C., Melia, K.R., Miserendino, M.J., Falls, W.A., Campeau, S., Davis, M. J. Neurosci. (1992) [Pubmed]
  29. Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Brown, M.R., Fisher, L.A., Spiess, J., Rivier, C., Rivier, J., Vale, W. Endocrinology (1982) [Pubmed]
  30. Hormonal, drug, and dietary factors affecting peptidyl glycine alpha-amidating monooxygenase activity in various tissues of the adult male rat. Mains, R.E., Myers, A.C., Eipper, B.A. Endocrinology (1985) [Pubmed]
  31. Localization and analyses of small drug molecules in rat brain tissue sections. Wang, H.Y., Jackson, S.N., McEuen, J., Woods, A.S. Anal. Chem. (2005) [Pubmed]
  32. Corticotropin-releasing factor inhibits the response of trigeminal neurons to noxious heat. Poree, L.R., Dickenson, A.H., Wei, E.T. Brain Res. (1989) [Pubmed]
  33. Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis. Kitamura, H., Okamoto, S., Shimamoto, Y., Morimatsu, M., Terao, A., Saito, M. Cell. Mol. Life Sci. (1998) [Pubmed]
  34. Increased ganglionic tyrosine hydroxylase and dopamine-beta-hydroxylase activities following preganglionic nerve stimulation: role of nicotine receptors. Chalazonitis, A., Rice, P.J., Zigmond, R.E. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  35. Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-alpha production in vivo: involvement of the sympathetic nervous system. Bencsics, A., Elenkov, I.J., Vizi, E.S. J. Neuroimmunol. (1997) [Pubmed]
  36. Potent suppressive effects of urocortin on splenic lymphocyte activity in rats. Okamoto, S., Ishikawa, I., Kimura, K., Saito, M. Neuroreport (1998) [Pubmed]
  37. Evidence for sympathetic and adrenal involvement in the immunomodulatory effects of acute morphine treatment in rats. Fecho, K., Maslonek, K.A., Dykstra, L.A., Lysle, D.T. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  38. Nicotine cue in rats: effects of central administration of ganglion-blocking drugs. Kumar, R., Reavill, C., Stolerman, I.P. Br. J. Pharmacol. (1987) [Pubmed]
  39. SK&F 87516, a close analog of fenoldopam, is a partial agonist at dopamine-1 and alpha-2 receptors and produces stimulation of 5-hydroxytryptamine-2 receptors in the cardiovascular system of the rat. Le Monnier de Gouville, A.C., Lawson, K., Thiry, C., Cavero, I. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  40. Microinjections of norepinephrine into the intermediolateral cell column of the spinal cord exert excitatory as well as inhibitory effects on the cardiac function. Sundaram, K., Murugaian, J., Sapru, H. Brain Res. (1991) [Pubmed]
WikiGenes - Universities