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MeSH Review

Uterine Inertia

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Disease relevance of Uterine Inertia


High impact information on Uterine Inertia


Chemical compound and disease context of Uterine Inertia

  • Prostaglandin E2 vaginal suppositories may be useful in the treatment of persistent postpartum uterine atony [9].
  • Five patients with severe postpartum hemorrhage due to uterine atony and unresponsive to oxytocin, ergonovine, and massage were treated with intramyometrial injection of 250 micrograms of prostaglandin (15S)-15-methyl PGF2 alpha-Tham [10].
  • In cases of heavy bleeding and signs of uterine atony, ethylergometrine (0.2 mg Methergin) and oxytocin (40 i.e. Syntocinon in 500 ml, 5.5% glucose) were administered intravenously [11].
  • After delivery, opioids (sufentanil 0.4 x hr-1) were used to limit the use of inhalational anaesthesia which may contribute to uterine atony [12].
  • Of these, 178 with a spontaneous start of labour and vaginal delivery were studied with respect to the effect of epidural block with bupivacaine-adrenaline on the course of labour and the condition of the infant in women with normal uterine activity and women with primary uterine inertia treated with oxytocin infusion [13].

Biological context of Uterine Inertia

  • Similarly, there were no significant differences between ET-1 plasma levels in normal pregnancies and other complicated pregnancies except for two cases in which much blood was lost due to uterine atony and abruptio placenta [14].

Analytical, diagnostic and therapeutic context of Uterine Inertia


  1. Buccal misoprostol to prevent hemorrhage at cesarean delivery: a randomized study. Hamm, J., Russell, Z., Botha, T., Carlan, S.J., Richichi, K. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  2. Severe hypotension due to intramyometrial injection of prostaglandin E2. Kilpatrick, A.W., Thorburn, J. Anaesthesia. (1990) [Pubmed]
  3. Effect of dantrolene sodium on contractility of isolated human uterine muscle. Shin, Y.K., Kim, Y.D., Collea, J.V., Belcher, M.D. International journal of obstetric anesthesia. (1995) [Pubmed]
  4. Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section. Dansereau, J., Joshi, A.K., Helewa, M.E., Doran, T.A., Lange, I.R., Luther, E.R., Farine, D., Schulz, M.L., Horbay, G.L., Griffin, P., Wassenaar, W. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  5. Inadvertent administration of prostaglandin E1 instead of prostaglandin F2 alpha in a patient with uterine atony and hemorrhage. Reedy, M.B., McMillion, J.S., Engvall, W.R., Sulak, P.J., Fisher, N.L. Obstetrics and gynecology. (1992) [Pubmed]
  6. Does terbutaline cause uterine atony and increase intraoperative blood loss? Brown, M.S. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  7. Maternal arterial desaturation with 15-methyl prostaglandin F2 alpha for uterine atony. Hankins, G.D., Berryman, G.K., Scott, R.T., Hood, D. Obstetrics and gynecology. (1988) [Pubmed]
  8. Postpartum uterine atony after intravenous dantrolene. Weingarten, A.E., Korsh, J.I., Neuman, G.G., Stern, S.B. Anesth. Analg. (1987) [Pubmed]
  9. Treatment of postpartum uterine atony with prostaglandin E2 vaginal suppositories. Hertz, R.H., Sokol, R.J., Dierker, L.J. Obstetrics and gynecology. (1980) [Pubmed]
  10. Control of postpartum uterine atony by intramyometrial prostaglandin. Bruce, S.L., Paul, R.H., Van Dorsten, J.P. Obstetrics and gynecology. (1982) [Pubmed]
  11. Intravenous infusion of 15 methyl-prostaglandin F2 alpha (Prostinfenem) in women with heavy post-partum hemorrhage. Granström, L., Ekman, G., Ulmsten, U. Acta obstetricia et gynecologica Scandinavica. (1989) [Pubmed]
  12. Caesarean section and phaeochromocytoma resection in a patient with Von Hippel Lindau disease. Joffe, D., Robbins, R., Benjamin, A. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1993) [Pubmed]
  13. Effect of segmental epidural block on the course of labour and the condition of the infant during the neonatal period. Willdeck-Lund, G., Lindmark, G., Nilsson, B.A. Acta anaesthesiologica Scandinavica. (1979) [Pubmed]
  14. Comparison of endothelin-1 concentrations in normal and complicated pregnancies. Otani, S., Usuki, S., Saitoh, T., Yanagisawa, M., Iwasaki, H., Tanaka, J., Suzuki, N., Fujino, M., Goto, K., Masaki, T. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  15. Prophylactic intramyometrial carboprost tromethamine does not substantially reduce blood loss relative to intramyometrial oxytocin at routine cesarean section. Catanzarite, V.A. American journal of perinatology. (1990) [Pubmed]
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