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Chemical Compound Review

Partocon     1-[[19-amino-10-(2- aminocarbonylethyl)-7...

Synonyms: Presoxin, Synpitan, Syntocin, Uteracon, Oxtocin, ...
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Disease relevance of Syntocinon


Psychiatry related information on Syntocinon


High impact information on Syntocinon

  • Immunocytochemical studies with an antiserum against synthetic oxytocin-like molecule provided the cytological basis for existence of a neuropeptide, since large amounts of immunoreactive neurons were detected in the central nervous systems of E. octoculata [8].
  • A dual mechanism of action of ocytocin in rat epididymal fat cells [9].
  • Synthetic oxytocin (OT) was infused iv in four men at 3 mU/min, and the rate was doubled every 90 min for a total of three infusion periods [10].
  • The PRF material could be separated from oxytocin by gel sieving and was active in the presence of dopamine in vitro unlike synthetic oxytocin and in cell preparations in which the oxytocin-responsive lactotrophs had been removed by selective cytotoxin cell targeting using an oxytocin-ricin A chain cytotoxic conjugate [11].
  • The binding of ocytocin, vasopressin, and the tripeptide analogue of the N-terminal sequence of ocytocin, Cys(S-Me)-Tyr-Ile-NH2, results in an increase of S020,W and a decrease in both the reduced viscosity and rotational relaxation time of the bis-liganded dimeric species vs. the nonliganded form [12].

Biological context of Syntocinon

  • Effect of 48-hour infusion of the synthetic oxytocin antagonist, [1-beta-mercapto(beta-(CH2)5)1(OMe)Tyr2,Orn8]-oxytocin, on myometrial activity of pregnant sheep at 139-140 days of gestation [13].
  • Six patients in the saline group had unsatisfactory uterine contraction compared with none in the syntocinon group (p = 0.025) [14].
  • OBJECTIVE: To compare intravenous oxytocin administration (Partocon 10 IU) with saline solution in the management of postpartum haemorrhage in the third stage of labour [15].
  • The effect of three anaesthetic techniques on blood loss and intra-uterine pressure changes in response to Syntocinon were studied in patients undergoing routine first trimester suction termination of pregnancy [16].
  • They were allocated randomly to one of two groups to receive either 1 ml (10 units) of syntocinon or 1 ml of saline (placebo) after cervical dilatation [14].

Anatomical context of Syntocinon

  • 1 The inhibitory effect of a commercial preparation of oxytocin (Syntocinon) was studied on the isolated vas deferens of the rat [17].
  • 4. Applied through paired perspex rings placed across the ventral surface of the brain stem, nicotine again produced release of vasopressin without ocytocin [18].
  • Patients in spontaneous labour had significantly lower beta-ELI than patients who had either artificial rupture of membranes or Syntocinon augmentation of labour [19].
  • In one patient, the cervix failed to dilate in spite of prolonged Pitocin infusion which did not induce significant uterine contractions, and the infusion did not reverse the marked fall in plasma PGFM after the early but transient rise [20].
  • The purpose of this study was to determine possible genotoxic and cytotoxic (or mitogenic) effects of high concentrations of oxytocin, active component of Syntocinon in cultures of human peripheral blood lymphocytes [21].

Associations of Syntocinon with other chemical compounds


Gene context of Syntocinon

  • Using retrodialysis, blockade of endogenous oxytocin action by infusion of an oxytocin receptor antagonist (des-Gly-NH2,d(CH2)5[Tyr(Me)2,Thr4]OVT) into the PVN or CeA reduced maternal aggression of HAB dams, whereas infusion of synthetic oxytocin into the PVN tended to increase aggression toward the intruder in LAB dams [26].
  • In the present vehicle-controlled study, we assessed the influence of a selective oxytocin receptor antagonist (des-Gly-NH2d(CH2)5 [Tyr(Me)2,Thr4] OVT; 0.75 microg/5 microl) or of synthetic oxytocin (0.1 microg and 1 microg/5 microl), infused into the lateral ventricle (i.c.v.), on the sleep pattern in male Wistar rats (n=7) [27].
  • Posterior pituitary extract (0.01-0.5 equivalent) from hens in each of the various stages of the reproductive cycle induced a concentration dependent PRL release [28].
  • In addition, immunohistochemical detection of the neuropeptides ocytocin and cholecystokinin was carried out on sections hybridized non-radioactively for vasopressin; as expected vasopressin mRNA did not co-exist with cholecystokinin, whereas a few oxytocin immunoreactive neurons in osmotically stimulated animals also contained vasopressin mRNA [29].
  • We conclude that translation of pro-ocytocin-neurophysin mRNA takes place soon after transcription and we propose that incomplete processing could be responsible for the low level of ocytocin in the early bovine corpus luteum [30].

Analytical, diagnostic and therapeutic context of Syntocinon


  1. Hyperbilirubinemia in infants of diabetic mothers. Peevy, K.J., Landaw, S.A., Gross, S.J. Pediatrics (1980) [Pubmed]
  2. Anaphylactoid reaction to oxytocin in pregnancy. Slater, R.M., Bowles, B.J., Pumphrey, R.S. Anaesthesia. (1985) [Pubmed]
  3. Oxytocic drugs and anaesthesia. A controlled clinical trial of ergometrine, syntocinon and normal saline during evacuation of the uterus after spontaneous abortion. Beeby, D., Morgan Hughes, J.O. Anaesthesia. (1984) [Pubmed]
  4. Variations in cesarean delivery for fetal distress. Hueston, W.J., McClaflin, R.R., Claire, E. The Journal of family practice. (1996) [Pubmed]
  5. Uterine blood flow and myometrial activity at menstruation, and the action of vasopressin and a synthetic antagonist. Hauksson, A., Akerlund, M., Melin, P. British journal of obstetrics and gynaecology. (1988) [Pubmed]
  6. Oxytocin in obsessive compulsive disorder. den Boer, J.A., Westenberg, H.G. Peptides (1992) [Pubmed]
  7. Brief report: pitocin induction in autistic and nonautistic individuals. Gale, S., Ozonoff, S., Lainhart, J. Journal of autism and developmental disorders. (2003) [Pubmed]
  8. Structural characterization of a novel neuropeptide from the central nervous system of the leech Erpobdella octoculata. The leech osmoregulator factor. Salzet, M., Bulet, P., Weber, W.M., Clauss, W., Verger-Bocquet, M., Malecha, J. J. Biol. Chem. (1996) [Pubmed]
  9. A dual mechanism of action of ocytocin in rat epididymal fat cells. Muchmore, D.B., Little, S.A., de Haën, C. J. Biol. Chem. (1981) [Pubmed]
  10. Clearance studies of oxytocin in humans using radioimmunoassay measurements of the hormone in plasma and urine. Amico, J.A., Ulbrecht, J.S., Robinson, A.G. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  11. A nonoxytocinergic prolactin releasing factor and a nondopaminergic prolactin inhibiting factor in bovine neurointermediate lobe extracts: in vitro and in vivo studies. Samson, W.K., Martin, L., Mogg, R.J., Fulton, R.J. Endocrinology (1990) [Pubmed]
  12. Binding of neurohypophyseal peptides to neurophysin dimer promotes formation of compact and spherical complexes. Rholam, M., Nicolas, P., Cohen, P. Biochemistry (1982) [Pubmed]
  13. Effect of 48-hour infusion of the synthetic oxytocin antagonist, [1-beta-mercapto(beta-(CH2)5)1(OMe)Tyr2,Orn8]-oxytocin, on myometrial activity of pregnant sheep at 139-140 days of gestation. Owiny, J.R., Mitchell, M., Nathanielsz, P.W. Biol. Reprod. (1992) [Pubmed]
  14. The effect of syntocinon on blood loss during first trimester suction curettage. Ali, P.B., Smith, G. Anaesthesia. (1996) [Pubmed]
  15. Routine oxytocin in the third stage of labour: a placebo controlled randomised trial. Nordström, L., Fogelstam, K., Fridman, G., Larsson, A., Rydhstroem, H. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  16. Anaesthesia for suction termination of pregnancy. West, S.L., Moore, C.A., Gillard, M., Browne, P.D. Anaesthesia. (1985) [Pubmed]
  17. Spurious effects of commercial preparations of oxytocin on the isolated vas deferens of the rat. Botting, J.H. Br. J. Pharmacol. (1981) [Pubmed]
  18. Vasopressin release by nicotine: the site of action. Feldberg, W., Guertzenstein, P.G., Rocha e Silva, M. Br. J. Pharmacol. (1975) [Pubmed]
  19. Influence of medication, pain and progress in labour on plasma beta-endorphin-like immunoreactivity. Thomas, T.A., Fletcher, J.E., Hill, R.G. British journal of anaesthesia. (1982) [Pubmed]
  20. Oxytocin and the initiation of human parturition. IV. Plasma concentrations of oxytocin and 13,14-dihydro-15-keto-prostaglandin F2 alpha during induction of labor by artificial rupture of the membranes. Husslein, P., Kofler, E., Rasmussen, A.B., Sumulong, L., Fuchs, A.R., Fuchs, F. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  21. In vitro cytogenetic analysis of the effects of oxytocin on human peripheral blood lymphocytes. Djelić, N., Soldatović, B., Andjelković, M., Cvetković, D. Mutat. Res. (1996) [Pubmed]
  22. Clinical utility of multiple-dose administration of prostaglandin E2 gel. Mainprize, T., Nimrod, C., Dodd, G., Persaud, D. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  23. Characterization of a synthetic peptide impurity by fast-atom bombardment-tandem mass spectrometry and gas chromatography-mass spectrometry. Burinsky, D.J., Dunphy, R., Oyler, A.R., Shaw, C.J., Cotter, M.L. Journal of pharmaceutical sciences. (1992) [Pubmed]
  24. The control of blood loss at cesarean section with intramyometrial prostaglandin F2 alpha analog versus intravenous synthetic oxytocin. Ezeh, U.O., Pearson, M. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  25. A comparison of prostaglandin E2 gel and prostaglandin F2 alpha gel for preinduction cervical ripening. Neilson, D.R., Prins, R.P., Bolton, R.N., Mark, C., Watson, P. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  26. Brain oxytocin correlates with maternal aggression: link to anxiety. Bosch, O.J., Meddle, S.L., Beiderbeck, D.I., Douglas, A.J., Neumann, I.D. J. Neurosci. (2005) [Pubmed]
  27. Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Lancel, M., Krömer, S., Neumann, I.D. Regul. Pept. (2003) [Pubmed]
  28. Evidence of a role for the turkey posterior pituitary in prolactin release. el Halawani, M.E., Silsby, J.L., Koike, T.I., Robinzon, B. Gen. Comp. Endocrinol. (1992) [Pubmed]
  29. Simultaneous detection of neuropeptides and messenger RNA in the magnocellular hypothalamo-neurohypophysial system by a combination of non-radioactive in situ hybridization histochemistry and immunohistochemistry. Larsen, P.J., Mikkelsen, J.D. Histochemistry (1994) [Pubmed]
  30. Synthesis and processing of pro-ocytocin in bovine corpus luteum and granulosa cells. Camier, M., Benveniste, D., Barré, N., Brakch, N., Cohen, P. Mol. Cell. Endocrinol. (1991) [Pubmed]
  31. Effect of the Confidential Enquiries into Maternal Deaths on the use of Syntocinon at Caesarean section in the UK. Bolton, T.J., Randall, K., Yentis, S.M. Anaesthesia. (2003) [Pubmed]
  32. Elevated plasma levels of oxytocin in obese subjects before and after gastric banding. Stock, S., Granström, L., Backman, L., Matthiesen, A.S., Uvnäs-Moberg, K. International journal of obesity. (1989) [Pubmed]
  33. Hypothalamic modulation of immunoreactive oxytocin in the rat thymus. Argiolas, A., Melis, M.R., Stancampiano, R., Mauri, A., Gessa, G.L. Peptides (1990) [Pubmed]
  34. Cesarean delivery on demand: what will it cost? Bost, B.W. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  35. Plasma concentrations of arginine vasopressin, oxytocin and angiotensin in patients with hymenoptera venom anaphylaxis. Hermann, K., von Eschenbach, C.E., von Tschirschnitz, M., Ring, J. Regul. Pept. (1993) [Pubmed]
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