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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Closing Volume

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Disease relevance of Closing Volume


High impact information on Closing Volume

  • METHODS: We assessed 262 consecutive climbers of Monte Rosa (4559 m), before ascent and about 24 h later on the summit 1 h after arriving, by clinical examination, electrocardiography, oximetry, spirometry, carbon monoxide transfer, and closing volume [4].
  • The slope of the alveolar plateau on the closing volume tracing showed a 271% increase 20 minutes after the prostaglandin administration, at which time the closing volume per cent (CV%) had decreased (P less than 0-01) and the closing capacity (CC%) had increased (P less than 0-05) [5].
  • MEASUREMENTS: Measurements of static and dynamic lung volumes, diffusing capacity of the lung for carbon monoxide (as measured by the single-breath method), nitrogen slope of the alveolar plateau, and closing volume (as measured by the single-breath O2 test) [6].
  • In two of three smokers the effect of airway pressure on closing volume was abolished by salbutamol [7].
  • The sensitivity of the closing volume to airway pressure could not be reproduced in three non-smokers exposed to a histamine aerosol [7].

Biological context of Closing Volume


Anatomical context of Closing Volume

  • Superoxide anion production by macrophages, studies of small airway integrity (closing volume, closing capacity, and the slope of Phase III of the single-breath nitrogen washout curve), and evaluation of alveolar gas exchange (diffusing capacity of carbon monoxide) were similar in both nonsmokers and marijuana smokers [12].

Associations of Closing Volume with chemical compounds


Gene context of Closing Volume

  • Pulmonary function testing consisted of the single breath nitrogen test (SBN2) to determine the closing volume (CV) and slope of the alveolar plateau, and a maximum expiratory flow volume curve (MEFV) to determine expiratory flow at low lung volumes [17].
  • 2. Immersion in water to the neck resulted in a small but significant fall in VC, FEV 1.0/FVC and TLC, and a rise in DLCO, but flow/volume curves and 'closing volume' were unchanged [18].
  • The closing volume also seems to be abnormal in the early course of the disease, while elevated lysozyme and beta2-microglobulin levels rather seem to reflect the extent of the pulmonary affection [19].


  1. In-vitro measurements of the regurgitation of mechanical mitral heart valve prostheses in case of atrial fibrillation. Mouret, F., Garitey, V., Fuseri, J., Rieu, R. J. Heart Valve Dis. (2001) [Pubmed]
  2. "Closing volume" changes in alloxan-induced pulmonary edema in anesthetized dogs. Lemen, R., Jones, J.G., Graf, P.D., Cowan, G. Journal of applied physiology. (1975) [Pubmed]
  3. Effects of salbutamol and propranolol on closing volume in extrinsic bronchial asthma. Patel, K.R., Kerr, J.W., MacKenzie, A.M. The Indian journal of chest diseases & allied sciences. (1976) [Pubmed]
  4. Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study. Cremona, G., Asnaghi, R., Baderna, P., Brunetto, A., Brutsaert, T., Cavallaro, C., Clark, T.M., Cogo, A., Donis, R., Lanfranchi, P., Luks, A., Novello, N., Panzetta, S., Perini, L., Putnam, M., Spagnolatti, L., Wagner, H., Wagner, P.D. Lancet (2002) [Pubmed]
  5. Pattern of total and regional lung function in subjects with bronchoconstriction induced by 15-me PGF2 alpha. Andersen, L.H., Secher, N.J. Thorax (1976) [Pubmed]
  6. Small airways obstruction syndrome. Stănescu, D. Chest (1999) [Pubmed]
  7. Comparison of active and passive manoeuvres on the pattern of airway closure in man. Jones, J.G., Minty, B.D. British journal of anaesthesia. (1978) [Pubmed]
  8. The unreliability of the maximal midexpiratory flow as an index of acute airway changes. Newball, H.H. Chest (1975) [Pubmed]
  9. Pulmonary limits of oxygen tolerance in man. Clark, J.M. Exp. Lung Res. (1988) [Pubmed]
  10. Nitrogen and bolus closing volumes: differences after histamine-induced bronchoconstriction. Benson, M.K., Newberg, L.A., Jones, J.G. Journal of applied physiology. (1975) [Pubmed]
  11. The effects of posture on venous admixture and respiratory dead space in health. Rea, H.H., Withy, S.J., Seelye, E.R., Harris, E.A. Am. Rev. Respir. Dis. (1977) [Pubmed]
  12. Marijuana smoking, pulmonary function, and lung macrophage oxidant release. Sherman, M.P., Roth, M.D., Gong, H., Tashkin, D.P. Pharmacol. Biochem. Behav. (1991) [Pubmed]
  13. Changes in pulmonary diffusing capacity and closing volume after running a marathon. Miles, D.S., Doerr, C.E., Schonfeld, S.A., Sinks, D.E., Gotshall, R.W. Respiration physiology. (1983) [Pubmed]
  14. Changes in airway calibre following pulmonary venous congestion. Jones, J.G., Lemen, R., Graf, P.D. British journal of anaesthesia. (1978) [Pubmed]
  15. The influence of atropine and cromolyn on human bronchial hyperreactivity to aerosolized prostaglandin F2 alpha. Newball, H.H., Lenfant, C. Respiration physiology. (1977) [Pubmed]
  16. The influence of bronchial smooth muscle tone on critical narrowing of dependent airways. Jones, J.G., Graf, P.D., Lemen, R. British journal of anaesthesia. (1978) [Pubmed]
  17. Small airway testing and smoking in predicting risk in surgical patients. Poe, R.H., Dass, T., Celebic, A. Am. J. Med. Sci. (1982) [Pubmed]
  18. Effects of immersion in water and changes in intrathoracic blood volume on lung function in man. Burki, N.K. Clinical science and molecular medicine. (1976) [Pubmed]
  19. Indices of inflammatory cell activity and pulmonary function in different stages of sarcoidosis. Schmekel, B., Hällgren, R., Stålenheim, G., Venge, P. Acta medica Scandinavica. (1982) [Pubmed]
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