Disease relevance of Vitreous Detachment

• PURPOSE: To investigate the effects of intravitreal injection of nattokinase (subtilisin NAT), a serine protease that is produced by Bacillus subtilis (natto), for induction of posterior vitreous detachment (PVD) [1].
• There were seven eyes with involutional macular thinning, pigment epithelial window defects on fluorescein angiography and no posterior vitreous detachment; six (86%) developed a macular hole [2].
• PURPOSE: To investigate whether interleukin-6 (IL-6) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in subjects without posterior vitreous detachment (PVD) [3].
• We have used perfluoroperhydrophenanthrene (Vitreon) to manage three cases of penetrating ocular trauma with concurrent retinal detachment and a partial vitreous detachment, either at the time of surgery or as noted ultrasonographically [4].
• The prevalence of posterior vitreous detachment (PVD) as well as all types of RP-related macular abnormalities--especially vitreoretinal interface alterations (VRIA), cystoid macular edema (CME), "bull's eye maculopathy" (BEM) and MH--was reported; statistical analyses and correlations were assessed by means of Student t test and Pearson chi2 [5].

High impact information on Vitreous Detachment

• Posterior Vitreous Detachment Induced by Nattokinase (Subtilisin NAT): A Novel Enzyme for Pharmacologic Vitreolysis [1].
• In eyes that develop ERM's before vitreous detachment, however, a layer of vitreous may be entrapped beneath the ERM and on adjacent membrane-free retina when PVD ocurs [6].
• Prevalence of posterior vitreous detachment in high myopia [7].
• Intravitreal triamcinolone staining observation of residual undetached cortical vitreous after posterior vitreous detachment [8].
• CONCLUSIONS: Our results suggested that activation of endogenous MMP-2 by exogenous plasmin is associated with the induction of posterior vitreous detachment [9].

Chemical compound and disease context of Vitreous Detachment

• Induction of vitreolysis and vitreous detachment with hyaluronidase and perfluoropropane gas [10].
• The instability of the vitreous gel, as reflected by rupture of the anterior vitreous face and an increased incidence of vitreous detachment supports the hypothesis of hyaluronic acid as a stabilizer of the gel [11].

Gene context of Vitreous Detachment

• Prior to tPA injection, 4 eyes had complete posterior vitreous detachment (PVD) and 9 eyes had no PVD [12].
• Posterior vitreous detachment (PVD) is the consequence of changes in the macromolecular structure of gel vitreous that result in liquefaction, concurrent with alterations in the extracellular matrix at the vitro-retinal interface that allow the posterior vitreous cortex to detach from the internal limiting lamina of the retina [13].
• Prevalence of posterior vitreous detachment in retinitis pigmentosa [14].
• Dilated fundus examination revealed a total posterior vitreous detachment, despite the young age of the patient, with numerous white intragel opacities that were compatible with remnants of the vasa hyaloidea propria [15].
• There was a significant reduction in the P50 amplitudes in the FE compared to the AMC with checks of 12', but there was no significant reduction with checks of 46'. In the FE with posterior vitreous detachment (PVD) (eleven cases), the P50 amplitudes with checks of 12' were greater than in the eyes without PVD [16].

Analytical, diagnostic and therapeutic context of Vitreous Detachment

• A priori explanatory variables included baseline presence of clinical and/or OCT signs suggesting macular traction, grade of diabetic maculopathy, posterior vitreous detachment, fluorescein leakage and ischaemia on angiography, presence of subretinal fluid, and peroperative indocyanine green (ICG) use [17].
• INTERVENTION: Pars plana vitrectomy, induction of posterior vitreous detachment (PVD), and gas tamponade were performed, with postoperative facedown positioning for 1 week [18].

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