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MeSH Review

Soy Foods

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Disease relevance of Soy Foods


High impact information on Soy Foods


Chemical compound and disease context of Soy Foods


Biological context of Soy Foods


Anatomical context of Soy Foods

  • The proposed method was applied to monitor isoflavone levels in soy foods and in human plasma, urine and breast milk after challenge with roasted soybeans [18].
  • Although the plasma genistein levels achievable with soy food feeding are unlikely to be sufficient to inhibit the growth of mature, established breast cancer cells by chemotherapeutic-like mechanisms, these levels are sufficient to regulate the proliferation of epithelial cells in the breast and thereby may cause a chemopreventive effect [19].

Associations of Soy Foods with chemical compounds

  • BACKGROUND: The discovery of equol in human urine more than 2 decades ago and the finding that it is bacterially derived from daidzin, an isoflavone abundant in soy foods, led to the current nutritional interest in soy foods [20].
  • CONCLUSIONS: This study does not provide evidence that ingestion of soy food or a VLFD significantly reduces estrogen concentrations in postmenopausal women [21].
  • The content of Gly m 4 in soy food products strongly depends on the degree of food processing [22].
  • Recently, the consumption of soy foods has been shown to reduce serum cholesterol concentrations [23].
  • Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA [24].

Gene context of Soy Foods

  • Evidence that pLH1 is theta-replicating could be deduced from the plasmid size, from the homology to the replication protein of the Bacillus natto theta-replicating plasmid pLS32, and from the identification of a putative resolvase gene (orf-195) [25].
  • Moreover, B. subtilis (natto) cells subjected to hydrochloric acid treatment, but not autoclaving, induced a higher secretion of IL-6 and IL-8 than intact cells [26].
  • We suggest that estrogenic substances, and also phytoestrogens present in soy food could, by increasing tumor tissue-located CYP27B1 activity and decreasing degradative CYP24 activity, augment tumor-localized 1,25-dihydroxyvitamin D3 levels and activity [27].
  • Miso intake was inversely significantly correlated with SHBG on Day 22 of the cycle (r = -0.36, p = 0.02) [28].
  • Frequent consumption of chicken (adjusted OR, 0.5; 95% CI, 0.3 to 0.98) and soy foods (adjusted OR, 0.4; 95% CI, 0.2 to 0.7) was significantly associated with a decreased risk of OPLL [29].

Analytical, diagnostic and therapeutic context of Soy Foods


  1. Elimination of plasmid-linked polyglutamate production by Bacillus subtilis (natto) with acridine orange. Hara, T., Aumayr, A., Fujio, Y., Ueda, S. Appl. Environ. Microbiol. (1982) [Pubmed]
  2. Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets. Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Barrett, J.C., Wang, T.T. Mol. Carcinog. (2004) [Pubmed]
  3. Phytoestrogens and healthy aging: gaps in knowledge. A workshop report. Lu, L.J., Tice, J.A., Bellino, F.L. Menopause (New York, N.Y.) (2001) [Pubmed]
  4. Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-Based Osteoporosis (JPOS) Study. Ikeda, Y., Iki, M., Morita, A., Kajita, E., Kagamimori, S., Kagawa, Y., Yoneshima, H. J. Nutr. (2006) [Pubmed]
  5. Time series analysis of aerobic bacterial flora during Miso fermentation. Onda, T., Yanagida, F., Tsuji, M., Shinohara, T., Yokotsuka, K. Lett. Appl. Microbiol. (2003) [Pubmed]
  6. Presence of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid, a precursor of a mutagenic nitroso compound, in soy sauce. Wakabayashi, K., Ochiai, M., Saitô, H., Tsuda, M., Suwa, Y., Nagao, M., Sugimura, T. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia by a principal flavor component of Japanese-style fermented soy sauce. Nagahara, A., Benjamin, H., Storkson, J., Krewson, J., Sheng, K., Liu, W., Pariza, M.W. Cancer Res. (1992) [Pubmed]
  8. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by dietary soy sauce. Benjamin, H., Storkson, J., Nagahara, A., Pariza, M.W. Cancer Res. (1991) [Pubmed]
  9. Characterization of poly-gamma-glutamate hydrolase encoded by a bacteriophage genome: possible role in phage infection of Bacillus subtilis encapsulated with poly-gamma-glutamate. Kimura, K., Itoh, Y. Appl. Environ. Microbiol. (2003) [Pubmed]
  10. Molecular cloning and nucleotide sequence of the 90k serine protease gene, hspK, from Bacillus subtilis (natto) No. 16. Yamagata, Y., Abe, R., Fujita, Y., Ichishima, E. Curr. Microbiol. (1995) [Pubmed]
  11. Oxalate content of soybean seeds (Glycine max: Leguminosae), soyfoods, and other edible legumes. Massey, L.K., Palmer, R.G., Horner, H.T. J. Agric. Food Chem. (2001) [Pubmed]
  12. A new defective phage containing a randomly selected 8 kilobase-pairs fragment of host chromosomal DNA inducible in a strain of Bacillus natto. Tsutsumi, Y., Hirokawa, H., Shishido, K. FEMS Microbiol. Lett. (1990) [Pubmed]
  13. selective production and characterization of levan by Bacillus subtilis (Natto) Takahashi. Shih, I.L., Yu, Y.T., Shieh, C.J., Hsieh, C.Y. J. Agric. Food Chem. (2005) [Pubmed]
  14. Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women. Setchell, K.D., Faughnan, M.S., Avades, T., Zimmer-Nechemias, L., Brown, N.M., Wolfe, B.E., Brashear, W.T., Desai, P., Oldfield, M.F., Botting, N.P., Cassidy, A. Am. J. Clin. Nutr. (2003) [Pubmed]
  15. Effect of traditional oriental soy products on iron absorption. Macfarlane, B.J., van der Riet, W.B., Bothwell, T.H., Baynes, R.D., Siegenberg, D., Schmidt, U., Tal, A., Taylor, J.R., Mayet, F. Am. J. Clin. Nutr. (1990) [Pubmed]
  16. Bacillus subtilis (natto) plasmid pLS20 mediates interspecies plasmid transfer. Koehler, T.M., Thorne, C.B. J. Bacteriol. (1987) [Pubmed]
  17. Acute cytogenetic effects of tyramine, MTCAs, NaCl and soy sauce on rat bone marrow cells in vivo. Fujie, K., Nishi, J., Wada, M., Maeda, S., Sugiyama, T. Mutat. Res. (1990) [Pubmed]
  18. HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids. Franke, A.A., Custer, L.J., Wang, W., Shi, C.Y. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  19. Soy isoflavonoids and cancer prevention. Underlying biochemical and pharmacological issues. Barnes, S., Sfakianos, J., Coward, L., Kirk, M. Adv. Exp. Med. Biol. (1996) [Pubmed]
  20. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Setchell, K.D., Clerici, C., Lephart, E.D., Cole, S.J., Heenan, C., Castellani, D., Wolfe, B.E., Nechemias-Zimmer, L., Brown, N.M., Lund, T.D., Handa, R.J., Heubi, J.E. Am. J. Clin. Nutr. (2005) [Pubmed]
  21. A controlled 2-mo dietary fat reduction and soy food supplementation study in postmenopausal women. Wu, A.H., Stanczyk, F.Z., Martinez, C., Tseng, C.C., Hendrich, S., Murphy, P., Chaikittisilpa, S., Stram, D.O., Pike, M.C. Am. J. Clin. Nutr. (2005) [Pubmed]
  22. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens. Mittag, D., Vieths, S., Vogel, L., Becker, W.M., Rihs, H.P., Helbling, A., Wüthrich, B., Ballmer-Weber, B.K. J. Allergy Clin. Immunol. (2004) [Pubmed]
  23. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. Dewell, A., Hollenbeck, C.B., Bruce, B. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  24. Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA. Fidler, M.C., Davidsson, L., Walczyk, T., Hurrell, R.F. Am. J. Clin. Nutr. (2003) [Pubmed]
  25. Complete sequence of plasmid pLH1 from lactobacillus helveticus ATCC15009: analysis reveals the presence of regions homologous to other native plasmids from the host strain. Thompson, J.K., Foley, S., McConville, K.J., Nicholson, C., Collins, M.A., Pridmore, R.D. Plasmid (1999) [Pubmed]
  26. Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto). Hosoi, T., Hirose, R., Saegusa, S., Ametani, A., Kiuchi, K., Kaminogawa, S. Int. J. Food Microbiol. (2003) [Pubmed]
  27. Regulation of extrarenal synthesis of 1,25-dihydroxyvitamin D3--relevance for colonic cancer prevention and therapy. Cross, H.S., Kállay, E., Khorchide, M., Lechner, D. Mol. Aspects Med. (2003) [Pubmed]
  28. Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women. Nagata, C., Kabuto, M., Kurisu, Y., Shimizu, H. Nutrition and cancer. (1997) [Pubmed]
  29. Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan. Okamoto, K., Kobashi, G., Washio, M., Sasaki, S., Yokoyama, T., Miyake, Y., Sakamoto, N., Ohta, K., Inaba, Y., Tanaka, H. J. Bone Miner. Metab. (2004) [Pubmed]
  30. Keynote address: hypoxic cell radiosensitizers: where next? Brown, J.M. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  31. Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection. Chung, W.C., Hui, K.Y., Cheng, S.C. Journal of chromatography. A. (2002) [Pubmed]
  32. Chemoprevention of N-nitroso-N-methylurea-induced rat mammary carcinogenesis by soy foods or biochanin A. Gotoh, T., Yamada, K., Yin, H., Ito, A., Kataoka, T., Dohi, K. Jpn. J. Cancer Res. (1998) [Pubmed]
  33. Degradation of wheat allergen in Japanese soy sauce. Kobayashi, M., Hashimoto, Y., Taniuchi, S., Tanabe, S. Int. J. Mol. Med. (2004) [Pubmed]
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