Disease relevance of Genes, rel

• The v-rel oncogene product from the avian reticuloendotheliosis virus strain T corresponds to a member of the Rel-related family of enhancer-binding proteins that includes both the mammalian 50- and 65-kDa subunits of the NF-kappa B transcription factor complex [1].
• To determine the role of these factors in regulating HIV gene expression, we fused the cDNAs encoding either of the two proteins derived by alternative splicing of the PRDII-BF1 gene or the c-rel gene to the DNA binding region of the yeast transcription factor GAL4 [2].
• An E. coli relA spoT double deletion mutant transformed with S. coelicolor rel gene suppresses the phenotype associated with (p)ppGpp deficiency [3].

High impact information on Genes, rel

• The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function [4].
• These two sets of isogenic pairs of rel+ and rel minus strains are commonly used in the study of rel gene function; however, NF161 is a mutant in the spoT gene whose product may be responsible for the degradation of ppGpp [5].
• The transcription factor NF-kappa B is a heterodimer consisting of two proteins encoded by different members of the rel gene family (p50 and p65) [6].
• The role of Rel in the monocyte/macrophage lineage was examined in mice with an inactivated c-rel gene [7].
• The involvement of NF-kappa B in the regulation of the p50 gene is also supported by the inhibition of the PMA activation of the promoter by an NF-kappa B transdominant negative mutant, as well as the product of the v-rel oncogene [8].

Chemical compound and disease context of Genes, rel

• The roles of the rel+ gene and of 4-thiouridine in killing and photoprotection of Escherichia coli by near-ultraviolet radiation [9].

Biological context of Genes, rel

• We further demonstrate that Tax induction of nuclear c-Rel expression is activated by the RelA (p65) subunit of NF-kappa B, which activates transcription of the c-rel gene through an intrinsic kappa B enhancer element [10].
• The active nuclear form of the NF-kappa B transcription factor complex is composed of two DNA binding subunits, NF-kappa B p65 and NF-kappa B p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product [11].
• Furthermore, the c-rel member of Rel/NF-kappa B transcription factor family was first identified as a cellular homologue of the v-rel oncogene, suggesting that other members of the Rel/NF-kappa B family are potentially oncogenes [12].
• The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70 [13].
• Serine phosphorylation of the v-rel oncogene product/pp40 complex [14].

Anatomical context of Genes, rel

• In this study, we show that the mice with a null mutation in the lymphoid-specific c-Rel gene have normal development of lymphoid tissues and T cell compartment [15].

Associations of Genes, rel with chemical compounds

• Cotransfection of cells from different species with the v-rel gene along with constructs expressing the chloramphenicol acetyl transferase gene under the control of different promoters revealed that p59v-rel is a cell-specific transcriptional transactivator of certain promoters [16].
• Role of the rel gene product in the control of cyclic adenosine 3',5'-monophosphate accumulation [17].
• This activates the rel gene product which forms ppGpp and pppGpp from GTP and ATP [18].
• The product of the v-rel oncogene is present at a low level, representing only about 0.003% of total methionine-labelled protein [19].

Gene context of Genes, rel

• The NF-kappa B transcription factor complex is composed of two proteins, designated p50 and p65, both having considerable homology to the product of the rel oncogene [20].
• The nuclear factor kappa-B 2 (NFKB2) gene is a member of the NFKB/Rel gene family, which is known to be a pivotal regulator of the acute phase of the inflammatory response and of immune responses [21].
• Portions of the v-rel gene were joined to the 5' segment of the trpE gene [22].
• Activation of IL-2 receptor alpha-chain gene by individual members of the rel oncogene family in association with serum response factor [23].
• The mechanism by which the products of the v-rel oncogene, the corresponding c-rel proto-oncogene, and the related dorsal gene of Drosophila melanogaster exert their effects is not clear [24].

References