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Gene Review

HIVEP1  -  human immunodeficiency virus type I...

Homo sapiens

Synonyms: CIRIP, CRYBP1, Cirhin interaction protein, GAAP, Gate keeper of apoptosis-activating protein, ...
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Disease relevance of HIVEP1


High impact information on HIVEP1

  • These pairs of zinc fingers are similar to pairs of zinc fingers in the protein encoded by the Drosophila homeotic gene spalt and in the human transcription factor PRDII-BF1 [3].
  • We have isolated a full-length cDNA clone encoding a protein (PRDII-BF1) that binds specifically to a positive regulatory domain (PRDII) of the human IFN-beta gene promoter, and to a similar sequence present in a number of other promoters and enhancers [4].
  • Although the function of PRDII-BF1 is not known, the level of its mRNA is inducible by serum and virus, albeit with different kinetics [4].
  • Near the C-terminal end of basonuclin and on the surface of a putative alpha-helix, there is a stripe of serine residues similar to that of the transcription factor PRDII-BF1 [5].
  • We report here approximately 6.5 kilobases of sequence of the MBP-1 (MHC enhancer binding protein 1) cDNA [6].

Biological context of HIVEP1


Anatomical context of HIVEP1


Associations of HIVEP1 with chemical compounds


Other interactions of HIVEP1


  1. HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1. Nomura, N., Zhao, M.J., Nagase, T., Maekawa, T., Ishizaki, R., Tabata, S., Ishii, S. J. Biol. Chem. (1991) [Pubmed]
  2. Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. Seeler, J.S., Muchardt, C., Suessle, A., Gaynor, R.B. J. Virol. (1994) [Pubmed]
  3. The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. Basson, M., Horvitz, H.R. Genes Dev. (1996) [Pubmed]
  4. A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Fan, C.M., Maniatis, T. Genes Dev. (1990) [Pubmed]
  5. Basonuclin: a keratinocyte protein with multiple paired zinc fingers. Tseng, H., Green, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. Baldwin, A.S., LeClair, K.P., Singh, H., Sharp, P.A. Mol. Cell. Biol. (1990) [Pubmed]
  7. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Hicar, M.D., Liu, Y., Allen, C.E., Wu, L.C. Genomics (2001) [Pubmed]
  8. A novel human homolog of eosinophil major basic protein. Plager, D.A., Adolphson, C.R., Gleich, G.J. Immunol. Rev. (2001) [Pubmed]
  9. Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. Maekawa, T., Sakura, H., Sudo, T., Ishii, S. J. Biol. Chem. (1989) [Pubmed]
  10. Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. Muchardt, C., Seeler, J.S., Nirula, A., Shurland, D.L., Gaynor, R.B. J. Virol. (1992) [Pubmed]
  11. Carbohydrate-binding proteins of human serum: isolation of two mannose/fucose-specific lectins. Taylor, M.E., Summerfield, J.A. Biochim. Biophys. Acta (1987) [Pubmed]
  12. Accumulation and elimination of cadmium and zinc in the Asian periwinkle Littorina brevicula. Han, S.J., Park, J.S., Lee, I.S. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. (2003) [Pubmed]
  13. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang, X., Li, J., Qin, H., Yang, H., Li, J., Zhou, P., Liang, Y., Han, H. J. Biol. Chem. (2005) [Pubmed]
  14. Synthetic inhibitors of regulatory proteins involved in the signaling pathway of the replication of human immunodeficiency virus 1. Otsuka, M., Fujita, M., Sugiura, Y., Yamamoto, T., Inoue, J., Maekawa, T., Ishii, S. Bioorg. Med. Chem. (1997) [Pubmed]
  15. Gene hunting without sequencing genomic clones: finding exon boundaries in cDNAs. Xu, G., Sze, S.H., Liu, C.P., Pevzner, P.A., Arnheim, N. Genomics (1998) [Pubmed]
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