Disease relevance of Rosmarinus

• In order to find new effective HIV protease inhibitors, two diterpenes (carnosic acid [1] and carnosol [5]) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol [2] and semisynthetic derivatives (7-O-methylrosmanol [3], 7-O-ethylrosmanol [4], and 11,12-O,O-dimethylcarnosol [6]) were prepared [1].
• The authors found that a rosemary (Rosmarinus officinalis L.) extract enhanced the production of NGF in T98G human glioblastoma cells [2].

High impact information on Rosmarinus

• A methanol extract of the leaves of the plant Rosmarinus officinalis L [3].
• The potent antioxidant properties of rosemary (Rosmarinus officinalis) extracts have been attributed to its major diterpene, carnosic acid [4].
• Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties [5].
• Changes in carotenoids, tocopherols and diterpenes during drought and recovery, and the biological significance of chlorophyll loss in Rosmarinus officinalis plants [6].
• Practical challenges related to accurate quantification of carnosic acid (CA), carnosol (CAR) and other phenolic diterpenes in extracts of rosemary leaves (Rosmarinus officinalis L.) are presented and discussed [7].

Associations of Rosmarinus with chemical compounds

• Response of abietane diterpenes to stress in Rosmarinus officinalis L.: new insights into the function of diterpenes in plants [8].
• A simple HPLC method for vitamin E (alpha-tocopherol) measurement in the leaves of Rosmarinus officinalis has been developed and validated [9].
• Ultrasound was used to increase the extraction efficiency of carnosic acid from the herb Rosmarinus officinalis using butanone, ethyl acetate and ethanol as solvents [10].
• The chemical composition and antimicrobial activity of essential oil-rich fractions obtained by supercritical CO2 extraction from Rosmarinus officinalis L. were investigated [11].
• Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway [12].

Gene context of Rosmarinus

• As part of a project to characterise plant-derived natural products that modulate bacterial multidrug resistance (MDR), bioassay-guided fractionation of a chloroform extract of the aerial parts of Rosmarinus officinalis led to the characterisation of the known abietane diterpenes carnosic acid (1), carnosol (2) and 12-methoxy-trans-carnosic acid [13].
• The most bioactive plant tissue was Allium cepa (skin), followed by Illicium religiosum (bark and wood), Fagopyrum esculentum (hull), Origanum officinalis (leaf), Rosmarinus officinalis (leaf), Pyrus pyrifolia (bark),Acanthopanax senticosus (bark), Eugenia caryophllata (leaf), and Erigeron annuus (whole) [14].
• The increase in bilirubin level and alanine aminotransferase activity in plasma induced by CCl(4) was completely normalized by Rosmarinus officinalis [15].

Analytical, diagnostic and therapeutic context of Rosmarinus

• Simple high-performance liquid chromatography method for alpha-tocopherol measurement in Rosmarinus officinalis leaves. New data on alpha-tocopherol content [9].
• The effects of the volatile oil extracted from the leaves of Rosmarinus officinalis on glucose and insulin levels were investigated in normal rabbits, after the administration of an intraperitoneal glucose tolerance test (GTT) [16].

References