Disease relevance of Butanone

• However, only 1 prostate cancer death was seen among workers specifically assigned to the MEK units [1].
• Detection of Epstein-Barr virus messenger RNA in Reed-Sternberg cells of Hodgkin's disease by in situ hybridization with biotinylated probes on specially processed modified acetone methyl benzoate xylene (ModAMeX) sections [2].
• Measurement of the VOC emission pattern from a pure culture of Lactococcus lactis confirmed the positive correlations for the protonated masses 89 (tentatively identified as butyric acid), 63 (tentatively identified as dimethylsulfide), 69 (likely isoprene) and 73 (likely butanone) [3].
• Simultaneous detection of intercellular adhesion molecules-1 (ICAM-1) and carcinoembryonic antigen (CEA) was investigated in AMeX (Acetone, Methyl benzoate and Xylene)-fixed, paraffin-embedded tumor sections of 24 adenocarcinomas of the lung, using the avidin-biotin-peroxidase complex (ABC) method [4].
• N-Hexane- and methylethylketone-induced polyneuropathy. Abnormal accumulation of glycogen in unmyelinated axons. Report of a case [5].

Psychiatry related information on Butanone

• A positive dose-response effect was indicated for daily alcohol consumption with respect to elevated blood levels of 2-butanone and acetone [6].

High impact information on Butanone

• In these studies, 14C-labeled DMHD and 2-butanone were synthesized and allowed to react with peripheral nerve [7].
• Proton-exchange reactions of acetone and butanone. Resolution of steps in catalysis by acetoacetate decarboxylase [8].
• Aspergillus alcohol dehydrogenase is produced in response to growth in the presence of a wide variety of inducers, of which the most effective are short-chain alcohols and ketones, e.g. butan-2-one and propan-2-ol [9].
• Microsomes oxidized 2-butanol to 2-butanone by a reaction which was partially sensitive to carbon monoxide and to competitive .OH scavengers [10].
• Apomyoglobin was prepared by an extremely mild modification of the acid/butanone technique, and the kinetics of the recombination reaction between this preparation and alkaline haematin were studied [11].

Chemical compound and disease context of Butanone

• Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [12].
• Moraxella sp. ADH reduces stereospecifically 2-butanone to produce (S)-2-butanol [13].
• A, MEK, and MiBK pretreatment at a dosage of 6.8 mmol/kg, given daily for 3 d, markedly potentiated CCl4-induced liver toxicity as indicated by a decrease in the CCl4 ED50 to 3.4, 4.6, and 1.8 mmol/kg, respectively, compared to vehicle-pretreated rats (17.1 mmol/kg) [14].
• Methylethyl ketoxime (CAS No. 96-29-7; MEKO; 2-butanone oxime), an antioxidant agent used in paints, resins, and adhesives, was tested for reproductive toxicity in a two-generation study with CD (Sprague-Dawley) rats [15].

Biological context of Butanone

• Alkylation, using ethyl iodide in 2-butanone, occurred in the N-1 and N-3 positions of the hydantoin ring when concentrated KOH was added to the reaction mixture [16].
• Effect of coexposure to methyl ethyl ketone (MEK) on n-hexane toxicokinetics in human volunteers [17].
• We found that high blood acetaldehyde concentrations inhibit intestinal ethanol absorption in an inverse proportion to peak acetaldehyde concentrations, decrease intestinal blood flow, and inhibit intestinal absorption of 2-butanone [18].
• Chinese hamsters were exposed to acetone, methyl ethyl ketone, ethyl acetate and 2-methoxy ethyl acetate, known to be strong inducers of aneuploidy in the yeast Saccharomyces cerevisiae [19].
• Nervous system responses of rats to subchronic inhalation of N-hexane and N-hexane + methyl-ethyl-ketone mixtures [20].

Anatomical context of Butanone

• The extraction of lipids from rat liver mitochondrial membranes by 2-butanone treatment inhibited the activity of membrane-bound monoamine oxidase -A but not -B [21].
• A bio-assay employing 1-day-old chick tracheas was used to characterize airway effects of 2-butanone and dimethylsulphoxide (Me2SO) extracts of 23 dust samples collected from water damaged (13) and control (10) Danish schools [22].
• Electron microscopic examination of hepatocytes from rats sacrificed 16 h after 2-butanol or 2-butanone revealed a marginal increase in the prevalence of smooth endoplasmic reticulum [23].
• Delipidation of carp liver mitochondria by treatment with methyl ethyl ketone (MEK) or Triton X-100 and then perchlorate greatly reduced MAO activities [24].
• "From the aerospace medicine residents' teaching file: toxic peripheral neuropathy, sacroiliitis, and mitral valve prolapse." The clinical presentation, evaluation and diagnosis of an aviator exposed to N-Hexane and Butanone are discussed [25].

Associations of Butanone with other chemical compounds

• Uptake and reaction kinetics of acetone, 2-butanone, 2,4-pentanedione, and acetaldehyde in sulfuric acid solutions [26].
• Haloperidol (4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1- butanone), a reference compound used for model development, disappeared from the intestinal lumen with a half-life of 14 +/- 3 min [27].
• Emerging contaminants forwhich k" was determined (at 25 degrees C and pH 7) include 1,4-dioxane (4.2 x 10(-5) M(-1) s(-1)), methyl t-butyl ether (MTBE) (1.0 x 10(-4) M(-1) s(-1)), and methyl ethyl ketone (MEK) (9.1 x 10(-5) M(-1) s(-1)) [28].
• Benzene, toluene, ethylbenzene, xylenes, acrolein, 2-butanone and the high molecular weight compounds exhibited little affect [29].
• Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6h/day, during days 6-20 of gestation [12].

Gene context of Butanone

• OBJECTIVES: To test the hypothesis that blockage of epidermal growth factor receptor (EGFR) or methylethylketone (MEK)1/2 kinase activities impairs the growth of kidney cancer cells and magnifies the growth inhibitory effect of the mammalian target of rapamycin (mTOR) inhibitor rapamycin [30].
• Cyclotron-produced NCA (186)Re was separated radiochemically from enriched (186)W (96.9%) targets using high-purity methyl ethyl ketone (MEK) [31].
• Methylethylketoxime, also known as MEKO or 2-butanone oxime (CAS No. 96-29-7), is a clear, colorless to light yellow liquid at room temperature [32].
• A 16-h pretreatment with either 2-butanone (2.1 ml/kg, p.o.) or 2,3-butanediol (2.12 ml/kg, p.o.) markedly enhanced the hepatotoxic response to CCl4 (0.1 ml/kg, i.p.), as measured by serum glutamic pyruvic transaminase activity and hepatic triglyceride content [33].
• Concentrations of acetone and 2-butanone measured using C18 cartridges were lower than those measured using silica gel cartridges [34].

Analytical, diagnostic and therapeutic context of Butanone

• The labeling yield varied from 91.68% plus or minus 6.05% to 95.18% plus or minus 2.13% according to the method of control used: the precipitation of fibrinogen by (NH4)2SO4 25% or thin-layer chromatography with methylethylketone as solvent [35].
• The performance of the PFAIMS was compared directly to that of a flame ionization detector (FID) for the separation of a ketone mixture from butanone to decanone [36].
• X-ray powder diffraction revealed the isostructurality of the solvates with acetone and methylethylketone [37].
• The FTIR identification limits, ranging from 0.01 mg/L for ethyl acetate, methylethyl ketone, and sevoflurane to 24 mg/L for methanol, generally allowed the detection of volatile-substance exposure at a lower level than is acutely toxic [38].
• (8 beta)-8-([125]Iodomethyl)-6-propylergoline (125I-3) was prepared by refluxing the mesyl analog with Na125I in methyl-ethyl-ketone, followed by HPLC, in a radiochemical yield greater than 70% [39].

References