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Chemical Compound Review

Iopidine     2,6-dichloro-N-(4,5-dihydro- 1H-imidazol-2...

Synonyms: Aplonidine, Apraclonidina, apraclonidine, Apraclonidinum, CHEMBL647, ...
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Disease relevance of C07668


High impact information on C07668


Chemical compound and disease context of C07668


Biological context of C07668


Anatomical context of C07668


Associations of C07668 with other chemical compounds


Gene context of C07668

  • Patients with HS have denervation supersensitivity of the alpha1 receptors in the iris stroma of the affected eye, making the pupil dilator responsive to apraclonidine [28].

Analytical, diagnostic and therapeutic context of C07668


  1. Comparison of apraclonidine and timolol in chronic open-angle glaucoma. A three-month study. Nagasubramanian, S., Hitchings, R.A., Demailly, P., Chuniaud, M., Pannarale, M.R., Pecori-Giraldi, J., Stodtmeister, R., Parsons, D.G. Ophthalmology (1993) [Pubmed]
  2. Apraclonidine and anterior segment laser surgery. Comparison of 0.5% versus 1.0% apraclonidine for prevention of postoperative intraocular pressure rise. Rosenberg, L.F., Krupin, T., Ruderman, J., McDaniel, D.L., Siegfried, C., Karalekas, D.P., Grewal, R.K., Gieser, D.K., Williams, R. Ophthalmology (1995) [Pubmed]
  3. Ocular effects of apraclonidine in Horner syndrome. Morales, J., Brown, S.M., Abdul-Rahim, A.S., Crosson, C.E. Arch. Ophthalmol. (2000) [Pubmed]
  4. High incidence of topical allergic reactions to 1% apraclonidine. Feibel, R.M. Arch. Ophthalmol. (1995) [Pubmed]
  5. The effects of antiglaucoma and systemic medications on ocular blood flow. Costa, V.P., Harris, A., Stefánsson, E., Flammer, J., Krieglstein, G.K., Orzalesi, N., Heijl, A., Renard, J.P., Serra, L.M. Progress in retinal and eye research. (2003) [Pubmed]
  6. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Hayasaka, Y., Hayasaka, S., Zhang, X.Y., Nagaki, Y. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  7. Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Wikberg-Matsson, A., Simonsen, U. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  8. New developments in the drug treatment of glaucoma. Hurvitz, L.M., Kaufman, P.L., Robin, A.L., Weinreb, R.N., Crawford, K., Shaw, B. Drugs (1991) [Pubmed]
  9. Apraclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris. Sugiyama, K., Kitazawa, Y., Kawai, K. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  10. Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions. Butler, P., Mannschreck, M., Lin, S., Hwang, I., Alvarado, J. Arch. Ophthalmol. (1995) [Pubmed]
  11. Incidence of brimonidine allergy in patients previously allergic to apraclonidine. Williams, G.C., Orengo-Nania, S., Gross, R.L. Journal of glaucoma. (2000) [Pubmed]
  12. The comparative ocular hypotensive effect of apraclonidine with timolol maleate in exfoliation versus primary open-angle glaucoma patients. Konstas, A.G., Maltezos, A., Mantziris, D.A., Sine, C.S., Stewart, W.C. Eye (London, England) (1999) [Pubmed]
  13. Comparing efficacies of 0.5% apraclonidine with 4% cocaine in the diagnosis of horner syndrome in pediatric patients. Chen, P.L., Chen, J.T., Lu, D.W., Chen, Y.C., Hsiao, C.H. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2006) [Pubmed]
  14. Adjunctive glaucoma therapy. A comparison of apraclonidine to dipivefrin when added to timolol maleate. Morrison, J.C., Robin, A.L. Ophthalmology (1989) [Pubmed]
  15. Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery. Chen, T.C., Ang, R.T., Grosskreutz, C.L., Pasquale, L.R., Fan, J.T. Ophthalmology (2001) [Pubmed]
  16. Effects of apraclonidine on aqueous humor dynamics in human eyes. Toris, C.B., Tafoya, M.E., Camras, C.B., Yablonski, M.E. Ophthalmology (1995) [Pubmed]
  17. Ocular perfusion pressure and visual field indice modifications induced by alpha-agonist compound (clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2%) topical administration. An acute study on primary open-angle glaucoma patients. Costagliola, C., Parmeggiani, F., Ciancaglini, M., D'Oronzo, E., Mastropasqua, L., Sebastiani, A. Ophthalmologica (2003) [Pubmed]
  18. Failure of apraclonidine to prevent delayed IOP elevation after Nd:YAG laser posterior capsulotomy. Nesher, R., Kolker, A.E. Transactions of the American Ophthalmological Society. (1990) [Pubmed]
  19. Chronic use of apraclonidine decreases its moderation of post-laser intraocular pressure spikes. Chung, H.S., Shin, D.H., Birt, C.M., Kim, C., Lee, D., Levin, D.S., Hakimzadeh, R., Juzych, M.S. Ophthalmology (1997) [Pubmed]
  20. Effect of apraclonidine on blood-aqueous barrier permeability to plasma protein in man. Mori, M., Araie, M. Exp. Eye Res. (1992) [Pubmed]
  21. Effects of 0.5% apraclonidine on optic nerve head and peripapillary retinal blood flow. Kim, T.W., Kim, D.M. The British journal of ophthalmology. (1997) [Pubmed]
  22. Effects of topical administration of 0.5% apraclonidine on intraocular pressure, pupil size, and heart rate in clinically normal dogs. Miller, P.E., Nelson, M.J., Rhaesa, S.L. Am. J. Vet. Res. (1996) [Pubmed]
  23. Effect of topical apraclonidine on flow properties of central retinal and ophthalmic arteries. Celiker, U.O., Celebi, S., Celiker, H., Celebi, H. Acta ophthalmologica Scandinavica. (1996) [Pubmed]
  24. Additive effect of 1% apraclonidine hydrochloride to nonselective beta-blockers. Yaldo, M.K., Shin, D.H., Parrow, K.A., Lee, S.H., Lee, S.Y. Ophthalmology (1991) [Pubmed]
  25. The rarity of clinically significant rise in intraocular pressure after laser peripheral iridotomy with apraclonidine. Lewis, R., Perkins, T.W., Gangnon, R., Kaufman, P.L., Heatley, G.A. Ophthalmology (1998) [Pubmed]
  26. A proposed mechanism for p-aminoclonidine allergenicity based on its relative oxidative lability. Thompson, C.D., Vachaspati, P.R., Kolis, S.P., Gulden, P.H., Garst, M.E., Wiese, A., Munk, S.A., Harman, W.D., Macdonald, T.L. Chem. Res. Toxicol. (1997) [Pubmed]
  27. Effectiveness of apraclonidine and acetazolamide in preventing postoperative intraocular pressure spikes after extracapsular cataract extraction. Feist, R.M., Palmer, D.J., Fiscella, R., Ernest, J.T., Tripathi, R., Torczynski, E., Farber, M. Journal of cataract and refractive surgery. (1995) [Pubmed]
  28. Topical apraclonidine in the diagnosis of suspected Horner syndrome. Freedman, K.A., Brown, S.M. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. (2005) [Pubmed]
  29. Effect of topical apraclonidine on the frequency of intraocular pressure elevations after combined extracapsular cataract extraction and trabeculectomy. Robin, A.L. Ophthalmology (1993) [Pubmed]
  30. Preventing intraocular pressure increase after phacoemulsification and the role of perioperative apraclonidine. Kasetti, S.R., Desai, S.P., Sivakumar, S., Sunderraj, P. Journal of cataract and refractive surgery. (2002) [Pubmed]
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