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MeSH Review


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Disease relevance of Tinospora

  • The aqueous, alcoholic, and chloroform extracts of the leaves of Tinospora cordifolia were administered in doses of 50, 100, 150 and 200 mg/kg body weight to normal and alloxan-diabetic rabbits [1].
  • Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis [2].
  • Pretreatment with tinospora cordifolia or gentamicin reduced mortality in mice injected with 1 x 10(8) E. coli intraperitoneally from 100% in controls to 17.8% and 11.1% respectively [3].

High impact information on Tinospora

  • Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits [1].
  • Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption [4].
  • In this article we present evidence to show that an alcoholic extract of Tinospora cordifolia (ALTC) enhances the differentiation of TAM to dendritic cells (DC) in response to granulocyte/macrophage-colony-stimulating factor, interleukin-4, and tumor necrosis factor [5].
  • Immobilized callus cultures of Tinospora cordifolia (Willd) Miers ex Hooks and Thoms were investigated to find out the combined effect of elicitation, cell permeabilization with chitosan and in situ product recovery by polymeric neutral resin-like Diaion HP 20 [4].
  • New lignan glucosides from the stems of Tinospora sinensis [6].

Chemical compound and disease context of Tinospora


Anatomical context of Tinospora


Associations of Tinospora with chemical compounds


Gene context of Tinospora

  • The ethanol extract of Tinospora smilacina showed inhibitory activities on COX-1, COX-2, 5-LO and PA(2) with the IC(50) values of 63.5, 81.2, 92.1 and 30.5 micro g/mL respectively [13].
  • The antioxidant activity of an arabinogalactan polysaccharide (TSP) isolated from Tinospora cordifolia, an Indian medicinal plant, was studied [14].
  • Efficacy of Tinospora cordifolia in allergic rhinitis [15].
  • The optimal doses for MDP, Metronidazole, Asparagus racemosus and Tinospora cordifolia were found to be 100 micrograms, 300 mg/kg, 200 mg/kg and 100 mg/kg respectively [16].
  • An alpha-D-glucan (RR1) composed of (1-->4) linked back bone and (1-->6) linked branches with a molecular mass of >550 kDa and exhibiting unique immune stimulating properties is isolated and characterized from the medicinal plant Tinospora cordifolia [17].

Analytical, diagnostic and therapeutic context of Tinospora


  1. Effect of Tinospora cordifolia on blood glucose and total lipid levels of normal and alloxan-diabetic rabbits. Wadood, N., Wadood, A., Shah, S.A. Planta Med. (1992) [Pubmed]
  2. Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis. Leyon, P.V., Kuttan, G. Journal of ethnopharmacology. (2004) [Pubmed]
  3. Immunotherapeutic modification of Escherichia coli peritonitis and bacteremia by Tinospora cordifolia. Thatte, U.M., Kulkarni, M.R., Dahanukar, S.A. Journal of postgraduate medicine. (1992) [Pubmed]
  4. Enhanced production of the polysaccharide arabinogalactan using immobilized cultures of Tinospora cordifolia by elicitation and in situ adsorption. Roja, G., Bhangale, A.S., Juvekar, A.R., Eapen, S., D'Souza, S.F. Biotechnol. Prog. (2005) [Pubmed]
  5. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells. Singh, N., Singh, S.M., Shrivastava, P. Immunopharmacology and immunotoxicology. (2005) [Pubmed]
  6. New lignan glucosides from the stems of Tinospora sinensis. Li, W., Koike, K., Liu, L., Lin, L., Fu, X., Chen, Y., Nikaido, T. Chem. Pharm. Bull. (2004) [Pubmed]
  7. Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Prince, P.S., Padmanabhan, M., Menon, V.P. Phytotherapy research : PTR. (2004) [Pubmed]
  8. Tinospora tuberculata suppresses nitric oxide synthesis in mouse macrophages. Yokozawa, T., Wang, T.S., Chen, C.P., Hattori, M. Biol. Pharm. Bull. (1999) [Pubmed]
  9. Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats. Stanely, P., Prince, M., Menon, V.P. Journal of ethnopharmacology. (2000) [Pubmed]
  10. Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa. Kongkathip, N., Dhumma-upakorn, P., Kongkathip, B., Chawananoraset, K., Sangchomkaeo, P., Hatthakitpanichakul, S. Journal of ethnopharmacology. (2002) [Pubmed]
  11. Comparative study of immunomodulating activity of Indian medicinal plants, lithium carbonate and glucan. Thatte, U.M., Dahanukar, S.A. Methods and findings in experimental and clinical pharmacology. (1988) [Pubmed]
  12. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Tinospora sinensis. Manjrekar, P.N., Jolly, C.I., Narayanan, S. Fitoterapia (2000) [Pubmed]
  13. Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth. Li, R.W., Leach, D.N., Myers, S.P., Leach, G.J., Lin, G.D., Brushett, D.J., Waterman, P.G. Phytotherapy research : PTR. (2004) [Pubmed]
  14. Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage. Subramanian, M., Chintalwar, G.J., Chattopadhyay, S. Redox Rep. (2002) [Pubmed]
  15. Efficacy of Tinospora cordifolia in allergic rhinitis. Badar, V.A., Thawani, V.R., Wakode, P.T., Shrivastava, M.P., Gharpure, K.J., Hingorani, L.L., Khiyani, R.M. Journal of ethnopharmacology. (2005) [Pubmed]
  16. Quantitation of microbicidal activity of mononuclear phagocytes: an in vitro technique. Rege, N.N., Dahanukar, S.A. Journal of postgraduate medicine. (1993) [Pubmed]
  17. Immune stimulating properties of a novel polysaccharide from the medicinal plant Tinospora cordifolia. Nair, P.K., Rodriguez, S., Ramachandran, R., Alamo, A., Melnick, S.J., Escalon, E., Garcia, P.I., Wnuk, S.F., Ramachandran, C. Int. Immunopharmacol. (2004) [Pubmed]
  18. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. Prince, P.S., Menon, V.P. Journal of ethnopharmacology. (1999) [Pubmed]
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