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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Coix

 
 
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Disease relevance of Coix

  • Hypolipidemic effects of crude extract of adlay seed (Coix lachrymajobi var. mayuen) in obesity rat fed high fat diet: relations of TNF-alpha and leptin mRNA expressions and serum lipid levels [1].
 

High impact information on Coix

  • Coix DNA gel blot analysis with maize DHPS cDNA as a probe showed a single strongly hybridizing band along with faint bands [2].
  • Complex C2 was not affected by the addition of the O2 antibody, suggesting the existence of a novel nuclear factor, CBF1, that binds to the promoter and makes protein-protein associations with other proteins present in Coix endosperm nuclei [3].
  • The DapA gene encoding the lysine biosynthetic enzyme dihydrodipicolinate synthase from Coix lacryma-jobi: cloning, characterization, and expression analysis [2].
  • The overall results suggest that the structural and regulatory genes involved in the expression of the 22 kDa-like alpha-prolamin genes of Coix, sorghum and maize, originated from a common ancestor, and that variations were introduced in the structural and regulatory sequences after species separation [4].
  • Like the alpha-zeins, the C1 and C2 alpha-coixins corresponded to 80% of total Coix prolamins [5].
 

Biological context of Coix

  • The Coix genome showed complex cross-hybridization sequences with the 22 kDa alpha-zein cDNA, while no cross-hybridization was observed with the 19 kDa cDNA clone.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • The DapA open reading frame is interrupted by two introns and encodes the 326 amino acid-long Coix DHPS protein, which is 95% identical to the maize DHPS protein [2].
  • Wheat (Triticum aestivum L.) haploids were produced by crossing with Job's tears (Coix lachryma-jobi L.) as the pollen parent [6].
 

Anatomical context of Coix

 

Associations of Coix with chemical compounds

  • F2 is a new O2-binding sequence related to the O2 target sites of the Coix alpha-coxin, the maize b-32 genes and the AP-1 pseudopalindrome [8].
  • The method by which these toxins were determined involves addition of an internal standard (zearalenone 6'-oxime) to barley and Job's-tears samples [9].
  • A sensitive and reliable method for liquid chromatographic (LC) determination of zearalenone and alpha-zearalenol in barley and Job's-tears was investigated [9].
  • Induction of the accumulation of 2-(2-hydroxy-4,7-dimethoxy-1,4-benzoxazin-3-one)-beta-D-glucopyranose (HDMBOA-Glc) by jasmonic acid (JA) was investigated in wheat, Job's tears (Coix lacryma-jobi), and rye [10].
  • Hulls of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) were extracted with methanol and then separated into water, 1-butanol, ethyl acetate, and hexane fractions [11].
 

Gene context of Coix

  • Purification and characterization of an insect alpha-amylase inhibitor/endochitinase from seeds of Job's Tears (Coix lachryma-jobi) [12].
  • The six reedbeds planted with Coix lacryma-jobi proved to be significantly more effective in pathogen removal and BOD reduction than the unplanted reedbeds [13].
  • Comparative physical localization of maize mir1 gene in Zea mays L. and Coix lacryma-jobi L [14].
 

Analytical, diagnostic and therapeutic context of Coix

References

  1. Hypolipidemic effects of crude extract of adlay seed (Coix lachrymajobi var. mayuen) in obesity rat fed high fat diet: relations of TNF-alpha and leptin mRNA expressions and serum lipid levels. Kim, S.O., Yun, S.J., Jung, B., Lee, E.H., Hahm, D.H., Shim, I., Lee, H.J. Life Sci. (2004) [Pubmed]
  2. The DapA gene encoding the lysine biosynthetic enzyme dihydrodipicolinate synthase from Coix lacryma-jobi: cloning, characterization, and expression analysis. Dante, R.A., Neto, G.C., Leite, A., Yunes, J.A., Arruda, P. Plant Mol. Biol. (1999) [Pubmed]
  3. Identification of a DNA-binding factor that recognizes an alpha-coixin promoter and interacts with a Coix Opaque-2 like protein. de Souza Filho, G.A., da Silva, M.J., Vettore, A.L., Yunes, J.A., Leite, A., Arruda, P., Ottoboni, L.M. Plant Mol. Biol. (1999) [Pubmed]
  4. Sequence analysis of 22 kDa-like alpha-coixin genes and their comparison with homologous zein and kafirin genes reveals highly conserved protein structure and regulatory elements. Ottoboni, L.M., Leite, A., Yunes, J.A., Targon, M.L., de Souza Filho, G.A., Arruda, P. Plant Mol. Biol. (1993) [Pubmed]
  5. Phylogenetic relationship of zeins and coixins as determined by immunological cross-reactivity and Southern blot analysis. Leite, A., Ottoboni, L.M., Targon, M.L., Silva, M.J., Turcinelli, S.R., Arruda, P. Plant Mol. Biol. (1990) [Pubmed]
  6. Production of wheat doubled haploids by pollination with Job's tears (Coix lachryma-jobi. L.). Mochida, K., Tsujimoto, H. J. Hered. (2001) [Pubmed]
  7. Inhibitory effects of methanol extract of seeds of Job's Tears (Coix lachryma-jobi L. var. ma-yuen) on nitric oxide and superoxide production in RAW 264.7 macrophages. Seo, W.G., Pae, H.O., Chai, K.Y., Yun, Y.G., Kwon, T.H., Chung, H.T. Immunopharmacology and immunotoxicology. (2000) [Pubmed]
  8. ACGT and vicilin core sequences in a promoter domain required for seed-specific expression of a 2S storage protein gene are recognized by the opaque-2 regulatory protein. Vincentz, M., Leite, A., Neshich, G., Vriend, G., Mattar, C., Barros, L., Weinberg, D., de Almeida, E.R., de Carvalho, M.P., Aragão, F., Gander, E.S. Plant Mol. Biol. (1997) [Pubmed]
  9. Sensitive determination of zearalenone and alpha-zearalenol in barley and Job's-tears by liquid chromatography with fluorescence detection. Tanaka, T., Teshima, R., Ikebuchi, H., Sawada, J., Terao, T., Ichinoe, M. Journal of AOAC International. (1993) [Pubmed]
  10. Induction of HDMBOA-Glc accumulation and DIMBOA-Glc 4-O-methyltransferase by jasmonic acid in poaceous plants. Oikawa, A., Ishihara, A., Iwamura, H. Phytochemistry (2002) [Pubmed]
  11. 2,2'-Diphenyl-1-picrylhydrazyl radical-scavenging active components from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) hulls. Kuo, C.C., Chiang, W., Liu, G.P., Chien, Y.L., Chang, J.Y., Lee, C.K., Lo, J.M., Huang, S.L., Shih, M.C., Kuo, Y.H. J. Agric. Food Chem. (2002) [Pubmed]
  12. Purification and characterization of an insect alpha-amylase inhibitor/endochitinase from seeds of Job's Tears (Coix lachryma-jobi). Ary, M.B., Richardson, M., Shewry, P.R. Biochim. Biophys. Acta (1989) [Pubmed]
  13. Subsurface flow reedbeds using alternative media for the treatment of domestic greywater in Monteverde, Costa Rica, Central America. Dallas, S., Ho, G. Water Sci. Technol. (2005) [Pubmed]
  14. Comparative physical localization of maize mir1 gene in Zea mays L. and Coix lacryma-jobi L. Han, Y.H., Wang, X.L., Liu, L.H., Song, Y.C. Yi Chuan Xue Bao (2004) [Pubmed]
  15. Molecular cloning and functional expression of cDNA encoding a cysteine proteinase inhibitor, cystatin, from Job's tears (Coix lacryma-jobi L. var. Ma-yuen Stapf). Yoza, K., Nakamura, S., Yaguchi, M., Haraguchi, K., Ohtsubo, K. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
 
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