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Chemical Compound Review

Zearalenol     (4S,8R,12E)-8,16,18- trihydroxy-4-methyl-3...

Synonyms: A-ZEARALENOL, cis-Zearalenol, SGCUT00105, SureCN109175, Z0166_SIGMA, ...
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Disease relevance of AIDS-181737


High impact information on AIDS-181737


Biological context of AIDS-181737


Anatomical context of AIDS-181737

  • Levels of zearalenone and alpha-zearalenol were: blood plasma 66 +/- 27 and 194 +/- 80 ng/ml, excreta 182 +/- 33 and 644 +/- 86 micrograms/g, lung 56 +/- 45 and 202 +/- 161 ng/g, heart 57 +/- 40 and 238 +/- 121 ng/g, kidney 122 +/- 25 and 477 +/- 53 ng/g, and liver 276 +/- 54 and 2715 +/- 590 ng/g, respectively [12].
  • When immature rat uteri were incubated with alpha-zearalenol in vitro, the maximum induction of the induced protein synthesis was obtained with 1 x 10(-6) M and the induction was detected 15 min after the start of the incubation [13].
  • Furthermore, the influence of alpha-zearalenol (3.75-30 microM) was appraised on the developmental competence of in vivo-derived zygotes during 5 days of in vitro culture [10].
  • The ZON metabolites alpha-zearalenol (ZOL) and beta-ZOL were recovered at the duodenum beside the parent toxin ZON [14].
  • The sheep was distinct from the pig and goat in having the highest alpha-zearalenol forming activity in the cytosol fraction when NADPH was used as coenzyme [15].

Associations of AIDS-181737 with other chemical compounds


Gene context of AIDS-181737


Analytical, diagnostic and therapeutic context of AIDS-181737


  1. The phytoestrogen alpha-zearalenol reverses endothelial dysfunction induced by oophorectomy in rats. Altavilla, D., Saitta, A., Galeano, M., Squadrito, G., Marino, D., Minutoli, L., Calapai, G., Deodato, B., D'Anna, R., Corrado, F., Caputi, A.P., Squadrito, F. Lab. Invest. (2001) [Pubmed]
  2. Binding rather than metabolism may explain the interaction of two food-Grade Lactobacillus strains with zearalenone and its derivative (')alpha-earalenol. El-Nezami, H., Polychronaki, N., Salminen, S., Mykkänen, H. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Investigations on cellular proliferation induced by zearalenone and its derivatives in relation to the estrogenic parameters. Minervini, F., Giannoccaro, A., Cavallini, A., Visconti, A. Toxicol. Lett. (2005) [Pubmed]
  4. Ability of structurally diverse natural products and synthetic chemicals to induce gene expression mediated by estrogen receptors from various species. Matthews, J.B., Fertuck, K.C., Celius, T., Huang, Y.W., Fong, C.J., Zacharewski, T.R. J. Steroid Biochem. Mol. Biol. (2002) [Pubmed]
  5. Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17 beta or alpha-zearalenol. Celius, T., Matthews, J.B., Giesy, J.P., Zacharewski, T.R. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  6. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Zinedine, A., Soriano, J.M., Molt??, J.C., Ma??es, J. Food Chem. Toxicol. (2007) [Pubmed]
  7. Multiresidue determination of zeranol and related compounds in bovine muscle by gas chromatography/mass spectrometry with immunoaffinity cleanup. Zhang, W., Wang, H., Wang, J., Li, X., Jiang, H., Shen, J. Journal of AOAC International (2006) [Pubmed]
  8. Zeranol is formed from Fusarium spp. toxins in cattle in vivo. Kennedy, D.G., Hewitt, S.A., McEvoy, J.D., Currie, J.W., Cannavan, A., Blanchflower, W.J., Elliot, C.T. Food additives and contaminants. (1998) [Pubmed]
  9. Effect of UDP-glucuronyltransferase induction on zearalenone metabolism. Pandey, A., Hassen, A.M., Benedict, D.R., Fitzpatrick, D.W. Toxicol. Lett. (1990) [Pubmed]
  10. The influence of the mycotoxins deoxynivalenol and zearalenol on in vitro maturation of pig oocytes and in vitro culture of pig zygotes. Alm, H., Greising, T., Brüssow, K.P., Torner, H., Tiemann, U. Toxicology in vitro : an international journal published in association with BIBRA. (2002) [Pubmed]
  11. Influence of zearalenone on reproductive system cell proliferation in gilts. Obremski, K., Gajecki, M., Zwierzchowski, W., Zielonka, L., Otrocka-Domagała, I., Rotkiewicz, T., Mikołajczyk, A., Gajecka, M., Polak, M. Polish journal of veterinary sciences. (2003) [Pubmed]
  12. Metabolism of high concentrations of dietary zearalenone by young male turkey poults. Olsen, M., Mirocha, C.J., Abbas, H.K., Johansson, B. Poult. Sci. (1986) [Pubmed]
  13. Synthesis of a specific protein induced by zearalenone and its derivatives in rat uterus. Kawabata, Y., Tashiro, F., Ueno, Y. J. Biochem. (1982) [Pubmed]
  14. Effects of Fusarium toxin-contaminated wheat grain on nutrient turnover, microbial protein synthesis and metabolism of deoxynivalenol and zearalenone in the rumen of dairy cows. Dänicke, S., Matthäus, K., Lebzien, P., Valenta, H., Stemme, K., Ueberschär, K.H., Razzazi-Fazeli, E., Böhm, J., Flachowsky, G. Journal of animal physiology and animal nutrition. (2005) [Pubmed]
  15. Species differences in zearalenone-reducing activity in subcellular fractions of liver from female domestic animals. Olsen, M., Kiessling, K.H. Acta pharmacologica et toxicologica. (1983) [Pubmed]
  16. Development of a multiresidue method for analysis of major Fusarium mycotoxins in corn meal using liquid chromatography/tandem mass spectrometry. Cavaliere, C., Foglia, P., Pastorini, E., Samperi, R., Laganà, A. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  17. Effects of graded levels of Fusarium-toxin-contaminated wheat in Pekin duck diets on performance, health and metabolism of deoxynivalenol and zearalenone. Dänicke, S., Ueberschär, K.H., Valenta, H., Matthes, S., Matthäus, K., Halle, I. Br. Poult. Sci. (2004) [Pubmed]
  18. Inhibitory effects of alpha-zearalenol on angiotensin II-induced integrin beta3 mRNA via suppression of nuclear factor-kappaB. Li, S.M., Wang, X.M., Qiu, J., Si, Q., Guo, H.Y., Sun, R.Y., Wu, Q.X. Biomed. Environ. Sci. (2005) [Pubmed]
  19. Transformations of zearalenone and alpha-zearalanol by homogenates of human prostate glands. Thouvenot, D., Morfin, R., Di Stefano, S., Picart, D. Eur. J. Biochem. (1981) [Pubmed]
  20. Interlaboratory ring test of time-resolved fluoroimmunoassays for zeranol and alpha-zearalenol and comparison with zeranol test kits. Cooper, K.M., Ribeiro, L., Alves, P., Vozikis, V., Tsitsamis, S., Alfredsson, G., Lövgren, T., Tuomola, M., Takalo, H., Iitia, A., Sterk, S.S., Blokland, M., Kennedy, D.G. Food additives and contaminants. (2003) [Pubmed]
  21. On the interactions between Fusarium toxin-contaminated wheat and non-starch-polysaccharide hydrolysing enzymes in turkey diets on performance, health and carry-over of deoxynivalenol and zearalenone. Dänicke, S., Valenta, H., Ueberschär, K.H., Matthes, S. Br. Poult. Sci. (2007) [Pubmed]
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