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Chemical Compound Review

SureCN346875     (2S)-2,3-dihydropyridine-2,6- dicarboxylic...

Synonyms: CHEBI:18042, AC1L98FU, C03340, Dihydrodipicolinic acid, L-2,3-Dihydrodipicolinate, ...
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Disease relevance of dihydrodipicolinate


High impact information on dihydrodipicolinate


Chemical compound and disease context of dihydrodipicolinate


Associations of dihydrodipicolinate with other chemical compounds


Gene context of dihydrodipicolinate

  • For all seven protein systems considered (HIV-1 protease, dihydrodipicolinate reductase, Rnase T1, streptavidin, pp60c-Src SH2 domain, Hsp90 molecular chaperone, and bovine beta-trypsin) the binding enthalpy of 25 small molecular weight peptide and nonpeptide ligands can be accounted for with a standard error of +/-0.3 kcal x mol(-1) [15].
  • The L-lysine biosynthetic pathway of the gram-negative obligate methylotroph Methylophilus methylotrophus AS1 was examined through characterization of the enzymes aspartokinase (AK), aspartsemialdehyde dehydrogenase, dihydrodipicolinate synthase (DDPS), dihydrodipicolinate reductase, and diaminopimelate decarboxylase [16].


  1. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Cirilli, M., Zheng, R., Scapin, G., Blanchard, J.S. Biochemistry (2003) [Pubmed]
  2. Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase, and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus. Mendelovitz, S., Aharonowitz, Y. Antimicrob. Agents Chemother. (1982) [Pubmed]
  3. Bacterial sporulation and regulation of dihydrodipicolinate synthase in ribonucleic acid polymerase mutants of Bacillus subtilis. Hoganson, D.A., Irgens, R.L., Doi, R.H., Stahly, D.P. J. Bacteriol. (1975) [Pubmed]
  4. Regulation of dihydrodipicolinate synthase during growth and sporulation of Bacillus cereus. Hoganson, D.A., Stahly, D.P. J. Bacteriol. (1975) [Pubmed]
  5. Characterization of dapB, a gene required by Pseudomonas syringae pv. tabaci BR2.024 for lysine and tabtoxinine-beta-lactam biosynthesis. Liu, L., Shaw, P.D. J. Bacteriol. (1997) [Pubmed]
  6. Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine. Karsten, W.E. Biochemistry (1997) [Pubmed]
  7. Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase. Reddy, S.G., Sacchettini, J.C., Blanchard, J.S. Biochemistry (1995) [Pubmed]
  8. Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase. Scapin, G., Blanchard, J.S., Sacchettini, J.C. Biochemistry (1995) [Pubmed]
  9. The DapA gene encoding the lysine biosynthetic enzyme dihydrodipicolinate synthase from Coix lacryma-jobi: cloning, characterization, and expression analysis. Dante, R.A., Neto, G.C., Leite, A., Yunes, J.A., Arruda, P. Plant Mol. Biol. (1999) [Pubmed]
  10. Factors modulating transcription and translation in vitro of ribosomal protein S20 and isoleucyl-tRNA synthetase from Escherichia coli. Wirth, R., Kohles, V., Böck, A. Eur. J. Biochem. (1981) [Pubmed]
  11. Threonine production by dihydrodipicolinate synthase-defective mutants of Brevibacterium flavum. Shiio, I. Biotechnology advances. (1990) [Pubmed]
  12. A new flavin enzyme catalyzing the reduction of dihydrodipicolinate in sporulating Bacillus subtilis I. Purification and properties. Kimura, K. J. Biochem. (1975) [Pubmed]
  13. A new flavin enzyme catalyzing the reduction of dihydrodipicolinate in sporulating Bacillus subtilis. II. Kinetics and regulatory function. Kimura, K., Goto, T. J. Biochem. (1975) [Pubmed]
  14. Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate. Turner, J.J., Healy, J.P., Dobson, R.C., Gerrard, J.A., Hutton, C.A. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  15. Structural parameterization of the binding enthalpy of small ligands. Luque, I., Freire, E. Proteins (2002) [Pubmed]
  16. Characterization of the L-lysine biosynthetic pathway in the obligate methylotroph Methylophilus methylotrophus. Gunji, Y., Tsujimoto, N., Shimaoka, M., Ogawa-Miyata, Y., Sugimoto, S., Yasueda, H. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
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