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MeSH Review


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Disease relevance of Centella


High impact information on Centella

  • Fibroblast cells grown in culture were used as a model system to evaluate the stimulation of wound healing by titrated extract from Centella asiatica (TECA) as well as by the four principal triterpenoid components of Centella [5].
  • This study was designed to investigate the therapeutic potential of meso 2,3-dimercaptosuccinic acid (DMSA) and one of its monoesters, monoisoamyl DMSA (MiADMSA), individually or when administered in combination with an extract of Centella asiatica against experimental lead intoxication in rats [6].
  • Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban [7].
  • Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica [8].
  • Here, we show that Centella asiatica ethanolic extract (100 microg mL-1) elicits a marked increase in neurite outgrowth in human SH-SY5Y cells in the presence of nerve growth factor (NGF) [9].

Chemical compound and disease context of Centella


Biological context of Centella


Associations of Centella with chemical compounds

  • Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats [13].
  • The drug "Titrated Extract from Centella asiatica" (TECA), used for its stimulating properties on the healing of wounds, is a mixture of 3 terpenes extracted from a tropical plant: asiatic acid (30%, w/w), madecassic acid (30%, w/w) and asiaticoside (40%, w/w) [14].
  • These findings demonstrate the cardio protective effect of Centella asiatica on antioxidant tissue defense system during adriamycin induced cardiac damage in rats [3].
  • Seven new oleanane-type triterpenoid saponins, hydrocotylosides I-VII (1-7), and one known saponin, udosaponin B (8), were isolated from the methanol extract of the whole plants of Hydrocotyle sibthorpioides.The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence [15].
  • To protect against the adverse effects of radiation, Centella asiatica (aqueous extract) was tested and compared with ondansetron, a standard antiemetic drug [16].

Gene context of Centella


Analytical, diagnostic and therapeutic context of Centella


  1. Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats. Guo, J.S., Cheng, C.L., Koo, M.W. Planta Med. (2004) [Pubmed]
  2. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Bilbao, I., Aguirre, A., Zabala, R., González, R., Ratón, J., Diaz Pérez, J.L. Contact Derm. (1995) [Pubmed]
  3. Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats. Gnanapragasam, A., Ebenezar, K.K., Sathish, V., Govindaraju, P., Devaki, T. Life Sci. (2004) [Pubmed]
  4. Hemorrhoids and varicose veins: a review of treatment options. MacKay, D. Alternative medicine review : a journal of clinical therapeutic. (2001) [Pubmed]
  5. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Coldren, C.D., Hashim, P., Ali, J.M., Oh, S.K., Sinskey, A.J., Rha, C. Planta Med. (2003) [Pubmed]
  6. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. Saxena, G., Flora, S.J. J. Pharm. Pharmacol. (2006) [Pubmed]
  7. Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban. Kim, O.T., Kim, M.Y., Huh, S.M., Bai, D.G., Ahn, J.C., Hwang, B. Plant Cell Rep. (2005) [Pubmed]
  8. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Park, B.C., Bosire, K.O., Lee, E.S., Lee, Y.S., Kim, J.A. Cancer Lett. (2005) [Pubmed]
  9. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. Soumyanath, A., Zhong, Y.P., Gold, S.A., Yu, X., Koop, D.R., Bourdette, D., Gold, B.G. J. Pharm. Pharmacol. (2005) [Pubmed]
  10. The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats. Cheng, C.L., Guo, J.S., Luk, J., Koo, M.W. Life Sci. (2004) [Pubmed]
  11. Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid. Grimaldi, R., De Ponti, F., D'Angelo, L., Caravaggi, M., Guidi, G., Lecchini, S., Frigo, G.M., Crema, A. Journal of ethnopharmacology. (1990) [Pubmed]
  12. In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Sampson, J.H., Raman, A., Karlsen, G., Navsaria, H., Leigh, I.M. Phytomedicine (2001) [Pubmed]
  13. Effects of Centella asiatica on ethanol induced gastric mucosal lesions in rats. Cheng, C.L., Koo, M.W. Life Sci. (2000) [Pubmed]
  14. Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Maquart, F.X., Bellon, G., Gillery, P., Wegrowski, Y., Borel, J.P. Connect. Tissue Res. (1990) [Pubmed]
  15. Hydrocotylosides I-VII, new oleanane saponins from hydrocotylesibthorpioides. Matsushita, A., Sasaki, Y., Warashina, T., Miyase, T., Noguchi, H., Vander Velde, D. J. Nat. Prod. (2004) [Pubmed]
  16. Protection against radiation-induced conditioned taste aversion by Centella asiatica. Shobi, V., Goel, H.C. Physiol. Behav. (2001) [Pubmed]
  17. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice. Jayashree, G., Kurup Muraleedhara, G., Sudarslal, S., Jacob, V.B. Fitoterapia (2003) [Pubmed]
  18. Effects of Centella asiatica extract on mucopolysaccharide metabolism in subjects with varicose veins. Arpaia, M.R., Ferrone, R., Amitrano, M., Nappo, C., Leonardo, G., del Guercio, R. International journal of clinical pharmacology research. (1990) [Pubmed]
  19. Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban. Kim, O.T., Ahn, J.C., Hwang, S.J., Hwang, B. Mol. Cells (2005) [Pubmed]
  20. Radioprotection of Swiss albino mouse by Centella asiatica extract. Sharma, J., Sharma, R. Phytotherapy research : PTR. (2002) [Pubmed]
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