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MeSH Review

Pemphigoid Gestationis

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Disease relevance of Pemphigoid Gestationis


High impact information on Pemphigoid Gestationis


Chemical compound and disease context of Pemphigoid Gestationis


Biological context of Pemphigoid Gestationis


Anatomical context of Pemphigoid Gestationis

  • The sera of seven out of eight patients with Herpes gestationis contained a factor which fixed C3 but not detectable amounts of immunoglobulin (Ig) on the basement membrane zone (BMZ) of normal human skin [13].

Gene context of Pemphigoid Gestationis

  • Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of the 180 kD bullous pemphigoid antigen [14].
  • Herpes gestationis is associated with a positive C3 deposition along the base of the epidermis in salt-split skin, with increased frequency of HLA-DR3 and also the combination DR3 and DR4 [15].

Analytical, diagnostic and therapeutic context of Pemphigoid Gestationis


  1. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. Giudice, G.J., Emery, D.J., Zelickson, B.D., Anhalt, G.J., Liu, Z., Diaz, L.A. J. Immunol. (1993) [Pubmed]
  2. Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins. Nakatani, C., Muramatsu, T., Shirai, T. Br. J. Dermatol. (1998) [Pubmed]
  3. Chronic herpes gestationis and antiphospholipid antibody syndrome successfully treated with cyclophosphamide. Castle, S.P., Mather-Mondrey, M., Bennion, S., David-Bajar, K., Huff, C. J. Am. Acad. Dermatol. (1996) [Pubmed]
  4. Specific dermatoses of pregnancy: an evidence-based systematic review. Kroumpouzos, G., Cohen, L.M. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  5. Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome. Diaz, L.A., Ratrie, H., Saunders, W.S., Futamura, S., Squiquera, H.L., Anhalt, G.J., Giudice, G.J. J. Clin. Invest. (1990) [Pubmed]
  6. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid. Liu, Z., Diaz, L.A., Swartz, S.J., Troy, J.L., Fairley, J.A., Giudice, G.J. J. Immunol. (1995) [Pubmed]
  7. Herpes gestationis. Ultrastructure and ultrastructural localization of in vivo-bound complement. Yaoita, H., Gullino, M., Katz, S.I. J. Invest. Dermatol. (1976) [Pubmed]
  8. Herpes gestationis and ritodrine. Dobson, R.L. J. Am. Acad. Dermatol. (1988) [Pubmed]
  9. Pyridoxine-responsive herpes gestationis. Burkhart, C.G. Archives of dermatology. (1982) [Pubmed]
  10. Herpes gestationis. Persistent disease activity 11 years post partum. Fine, J.D., Omura, E.F. Archives of dermatology. (1985) [Pubmed]
  11. Urinary neopterin and kynurenine in herpes gestationis. Marfella, A., Satriano, R.A., Polese, C., Perna, M., Pisani, M. Dermatologica (1991) [Pubmed]
  12. The majority of bullous pemphigoid and herpes gestationis serum samples react with the NC16a domain of the 180-kDa bullous pemphigoid antigen. Matsumura, K., Amagai, M., Nishikawa, T., Hashimoto, T. Arch. Dermatol. Res. (1996) [Pubmed]
  13. Herpes gestationis: studies on the binding characteristics, activity and pathogenetic significance of the complement-fixing factor. Carruthers, J.A., Ewins, A.R. Clin. Exp. Immunol. (1978) [Pubmed]
  14. Analysis of antigens recognized by autoantibodies in herpes gestationis. Usefulness of immunoblotting using a fusion protein representing an extracellular domain of the 180 kD bullous pemphigoid antigen. Murakami, H., Amagai, M., Higashiyama, M., Hashimoto, K., Chorzelski, T.P., Bhogal, B.S., Jenkins, R.E., Black, M.M., Zillikens, D., Nishikawa, T., Hashimoto, T. J. Dermatol. Sci. (1996) [Pubmed]
  15. Herpes gestationis (Pemphigoid gestationis). Al-Fouzan, A.W., Galadari, I., Oumeish, I., Oumeish, O.Y. Clin. Dermatol. (2006) [Pubmed]
  16. Immunopathologic study of herpes gestationis in mother and infant. Katz, A., Minto, J.O., Toole, J.W., Medwidsky, W. Archives of dermatology. (1977) [Pubmed]
  17. Specific detection of anti-cell surface antibodies in herpes gestationis sera. Hashimoto, T., Amagai, M., Murakami, H., Higashiyama, M., Hashimoto, K., Nishikawa, T. Exp. Dermatol. (1996) [Pubmed]
  18. Titration of herpes gestationis factor fixing to C3 in pemphigoid herpes gestationis associated with choriocarcinoma. do Valle Chiossi, M.P., Costa, R.S., Ferreira Roselino, A.M. Archives of dermatology. (2000) [Pubmed]
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