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Chemical Compound Review

AC1LEMBZ     4-[(1R,2R)-1-hydroxy-2-[2- (4...

Synonyms: SureCN12959065, CCG-205118, Lopac0_001041, NCGC00162324-01, NCGC00162324-02
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Disease relevance of ritodrine


High impact information on ritodrine


Chemical compound and disease context of ritodrine


Biological context of ritodrine

  • Moreover, 1 microM ritodrine, which is known to relax uterine muscle contraction, attenuated oxytocin-induced MAP kinase activity and phosphorylation [13].
  • To determine the effects of fetal beta-2 agonist exposure on fetal hepatic glycogen metabolism, we infused ritodrine at a rate of 1.3 +/- 0.4 microgram/kg/min (mean +/- SD) for 24 h into six chronically catheterized twin fetal lambs starting between 128 and 134 days gestation [14].
  • Infusion of ritodrine increased maternal heart rate 18 +/- 1% (P less than .0001), decreased maternal mean arterial pressure (MMAP) 4 +/- 1% (P less than .01), and decreased UBFV 5 +/- 1% (P less than .001) [15].
  • At 120 min ritodrine had increased maternal cardiac output 45 +/- 6% above baseline (P = 0.0001) in the ritodrine-lidocaine group and 39 +/- 6% above baseline (P = 0.0001) in the ritodrine-NS group [16].
  • To assess the effect of septal hypertrophy on cardiac function we obtained M-mode echocardiograms on day 1 of life in 41 infants exposed to ritodrine and 22 control infants matched for gestational age [17].

Anatomical context of ritodrine


Associations of ritodrine with other chemical compounds

  • Potentiometry reveals a very sensitive CE detection mode, with sub-micromolar detection limits for amines and the randomly chosen drugs quinine, clozapine, cocaine, heroine, noscapine, papaverine, and ritodrine [22].
  • To study the effects of beta-2 agonist on metabolic regulation in fetal lamb lung, ritodrine hydrochloride, a preferential beta-2 agonist, was infused i.v. at a rate of 1.3 +/- 0.4 micrograms/kg/min (mean +/- S.D.) for 24 hr into six twin chronically catheterized fetal lambs starting between 0.86 and 0.91 gestation [23].
  • Our data suggest that in infants weighing less than 1,000 g, control of labor with ritodrine for a minimum of 24 hours and administration of betamethasone can reduce significantly not only the incidence of respiratory distress syndrome but also mortality and morbidity [24].
  • Evidence that an atypical beta-adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol [25].
  • The agonists used were isoprenaline, oxyfedrine (atria only) and (except in brown adipocytes) ritodrine, which was a partial agonist in white adipocytes, atria and vas deferens [26].

Gene context of ritodrine


Analytical, diagnostic and therapeutic context of ritodrine


  1. Treatment of preterm labor with the beta-adrenergic agonist ritodrine. Caritis, S.N. N. Engl. J. Med. (1992) [Pubmed]
  2. Pulmonary edema after ritodrine therapy in a patient with preeclampsia. Gleicher, N., Bazile, F., Elrad, H. N. Engl. J. Med. (1982) [Pubmed]
  3. Sinus bradycardia following ritodrine withdrawal. Dean, H., Berliner, S., Garfinkel, D., Shoenfeld, A., Ovadia, J., Pinkhas, J. JAMA (1982) [Pubmed]
  4. Fetal death associated with severe ritodrine induced ketoacidosis. Schilthuis, M.S., Aarnoudse, J.G. Lancet (1980) [Pubmed]
  5. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Braden, G.L., von Oeyen, P.T., Germain, M.J., Watson, D.J., Haag, B.L. Kidney Int. (1997) [Pubmed]
  6. The mechanism of the insulin-like effects of ionic zinc. May, J.M., Contoreggi, C.S. J. Biol. Chem. (1982) [Pubmed]
  7. Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin. Little, S.A., de Haën, C. J. Biol. Chem. (1980) [Pubmed]
  8. Maternal and neonatal urinary excretion of sulfate and glucuronide ritodrine conjugates. Brashear, W.T., Kuhnert, B.R., Wei, R. Clin. Pharmacol. Ther. (1988) [Pubmed]
  9. Ritodrine pharmacokinetics. Kuhnert, B.R., Gross, T.L., Kuhnert, P.M., Erhard, P., Brashar, W.T. Clin. Pharmacol. Ther. (1986) [Pubmed]
  10. ARDS associated with the use of sympathomimetics and glucocorticoids for the treatment of premature labor. Bowen, R.E., Dedhia, H.V., Beatty, J., Schiebel, F., Koss, W., Granados, J. Crit. Care Med. (1983) [Pubmed]
  11. Ephedrine remains the vasopressor of choice for treatment of hypotension during ritodrine infusion and epidural anesthesia. McGrath, J.M., Chestnut, D.H., Vincent, R.D., DeBruyn, C.S., Atkins, B.L., Poduska, D.J., Chatterjee, P. Anesthesiology (1994) [Pubmed]
  12. Tocolysis with beta-adrenergic receptor agonists. Caughey, A.B., Parer, J.T. Semin. Perinatol. (2001) [Pubmed]
  13. Oxytocin stimulates mitogen-activated protein kinase activity in cultured human puerperal uterine myometrial cells. Ohmichi, M., Koike, K., Nohara, A., Kanda, Y., Sakamoto, Y., Zhang, Z.X., Hirota, K., Miyake, A. Endocrinology (1995) [Pubmed]
  14. Effects of beta-2 agonist on hepatic glycogen metabolism in the fetal lamb. Warburton, D., Parton, L., Buckley, S., Cosico, L., Saluna, T. Pediatr. Res. (1988) [Pubmed]
  15. The effect of vasopressor agents upon uterine artery blood flow velocity in the gravid guinea pig subjected to ritodrine infusion. Chestnut, D.H., Ostman, L.G., Weiner, C.P., Hdez, M.J., Wang, J.P. Anesthesiology (1988) [Pubmed]
  16. Does ritodrine worsen maternal hypotension during epidural anesthesia in gravid ewes? Chestnut, D.H., Pollack, K.L., Thompson, C.S., DeBruyn, C.S., Weiner, C.P. Anesthesiology (1990) [Pubmed]
  17. Ventricular septal thickness and cardiac function in neonates after in utero ritodrine exposure. Nuchpuckdee, P., Brodsky, N., Porat, R., Hurt, H. J. Pediatr. (1986) [Pubmed]
  18. Clearance and disposition of ritodrine in the fluid compartments of the fetal lamb during and after constant rate fetal intravenous infusion. Wright, M.R., Rurak, D.W., van der Weyde, M.P., Taylor, S.M., Axelson, J.E. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  19. Metabolic effects of ritodrine in the fetal lamb. van der Weyde, M.P., Wright, M.R., Taylor, S.M., Axelson, J.E., Rurak, D.W. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  20. Effects of ritodrine, a beta 2-adrenoceptor agonist, on smooth muscle cells of the myometrium of pregnant rats. Izumi, H., Kishikawa, T. Br. J. Pharmacol. (1982) [Pubmed]
  21. Effects of beta-2 agonist on tracheal fluid flow, surfactant and pulmonary mechanics in the fetal lamb. Warburton, D., Parton, L., Buckley, S., Cosico, L., Saluna, T. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  22. Coated wire potentiometric detection for capillary electrophoresis studied using organic amines, drugs, and biogenic amines. Sekula, J., Everaert, J., Bohets, H., Vissers, B., Pietraszkiewicz, M., Pietraszkiewicz, O., Du Prez, F., Vanhoutte, K., Prus, P., Nagels, L.J. Anal. Chem. (2006) [Pubmed]
  23. Effects of beta-2 agonist on metabolic regulation in the fetal lamb lung. Warburton, D., Parton, L., Buckley, S., Cosico, L., Saluna, T. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  24. Reduction of mortality, morbidity, and respiratory distress syndrome in infants weighing less than 1,000 grams by treatment with betamethasone and ritodrine. Papageorgiou, A.N., Doray, J.L., Ardila, R., Kunos, I. Pediatrics (1989) [Pubmed]
  25. Evidence that an atypical beta-adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol. Norman, B.J., Leathard, H.L. Br. J. Pharmacol. (1990) [Pubmed]
  26. Beta-adrenoceptor sensitivity of brown and white adipocytes after chronic pretreatment of rats with reserpine. Grassby, P.F., Arch, J.R., Wilson, C., Broadley, K.J. Biochem. Pharmacol. (1987) [Pubmed]
  27. Mitogen-activated protein kinase cascade is involved in endothelin-1-induced rat puerperal uterine contraction. Kimura, A., Ohmichi, M., Takeda, T., Kurachi, H., Ikegami, H., Koike, K., Masuhara, K., Hayakawa, J., Kanzaki, T., Kobayashi, M., Akabane, M., Inoue, M., Miyake, A., Murata, Y. Endocrinology (1999) [Pubmed]
  28. Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Nishimuta, H., Tsujimoto, M., Ogura, K., Hiratsuka, A., Ohtani, H., Sawada, Y. Pharm. Res. (2005) [Pubmed]
  29. Beta-3 versus beta-2 adrenergic agonists and preterm labour: in vitro uterine relaxation effects. Dennedy, M.C., Friel, A.M., Gardeil, F., Morrison, J.J. BJOG : an international journal of obstetrics and gynaecology. (2001) [Pubmed]
  30. Maternal magnesium sulfate treatment is associated with reduced brain-blood flow perfusion in preterm infants. Rantonen, T., Kääpä, P., Grönlund, J., Ekblad, U., Helenius, H., Kero, P., Välimäki, I. Crit. Care Med. (2001) [Pubmed]
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