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MeSH Review

Neuroepithelial Bodies

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Disease relevance of Neuroepithelial Bodies


High impact information on Neuroepithelial Bodies


Biological context of Neuroepithelial Bodies


Anatomical context of Neuroepithelial Bodies


Associations of Neuroepithelial Bodies with chemical compounds


Gene context of Neuroepithelial Bodies

  • Because NE cells, which occur as solitary cells or in neuroepithelial bodies (NEBS), comprise less than 1% of airway epithelia, we counted foci positive for each of the three NE markers--synaptophysin, calcitonin gene-related peptide (CGRP), and protein gene product (PGP) 9.5--and developed a method to analyze numerous airways in serial sections [20].
  • Immunoreactivity for cytokeratin was also noted for hyperplastic bronchiolar neuroepithelial bodies [21].
  • A widespread distribution of both solitary endocrine cells and neuroepithelial bodies immunoreactive for calcitonin was found [22].
  • Staining for acetylcholinesterase (strongly positive in intact neuroepithelial bodies) was not detectable after separation into single cells, culture, or exposure to NGF [23].
  • NCAM may function to form clusters of PNEC known as neuroepithelial bodies [24].

Analytical, diagnostic and therapeutic context of Neuroepithelial Bodies


  1. Human chorionic gonadotropin in lung and lung tumors. Immunohistochemical study on unbalanced distribution of subunits. Fukayama, M., Hayashi, Y., Koike, M., Hajikano, H., Endo, S., Okumura, H. Lab. Invest. (1986) [Pubmed]
  2. Hypoxic initiation of pulmonary hypertension is mediated by serotonin secretion from neuroepithelial bodies in chemodenervated dogs. Yelmen, N.K., Sahin, G., Oruç, T., Hacibekiroğlu, M. The Chinese journal of physiology. (2003) [Pubmed]
  3. Neuroendocrine structures in normal and diseased human lung. Mosca, L., Ceresoli, A., Anzanello, E., Mauri, F., Mariscotti, C., Timossi, R., Barbareschi, M., Mezzetti, M. Applied pathology. (1986) [Pubmed]
  4. Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. Sekhon, H.S., Jia, Y., Raab, R., Kuryatov, A., Pankow, J.F., Whitsett, J.A., Lindstrom, J., Spindel, E.R. J. Clin. Invest. (1999) [Pubmed]
  5. Lung endocrine-like cells in hamsters treated with diethylnitrosamine: alterations in vivo and in cell culture. Linnoila, R.I., Nettesheim, P., DiAugustine, R.P. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  6. Induction and spontaneous regression of intense pulmonary neuroendocrine cell differentiation in a model of preneoplastic lung injury. Sunday, M.E., Willett, C.G. Cancer Res. (1992) [Pubmed]
  7. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Giangreco, A., Reynolds, S.D., Stripp, B.R. Am. J. Pathol. (2002) [Pubmed]
  8. Alteration of pulmonary neuroendocrine cells during epithelial repair of naphthalene-induced airway injury. Peake, J.L., Reynolds, S.D., Stripp, B.R., Stephens, K.E., Pinkerton, K.E. Am. J. Pathol. (2000) [Pubmed]
  9. Ontogeny of neuroendocrine cells in human fetal lung. II. An immunohistochemical study. Stahlman, M.T., Kasselberg, A.G., Orth, D.N., Gray, M.E. Lab. Invest. (1985) [Pubmed]
  10. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Hong, K.U., Reynolds, S.D., Giangreco, A., Hurley, C.M., Stripp, B.R. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  11. Protein gene product 9.5 expression in the lungs of humans and other mammals. Immunocytochemical detection in neuroepithelial bodies, neuroendocrine cells and nerves. Lauweryns, J.M., Van Ranst, L. Neurosci. Lett. (1988) [Pubmed]
  12. Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia. Khoor, A., Gray, M.E., Singh, G., Stahlman, M.T. J. Histochem. Cytochem. (1996) [Pubmed]
  13. The role of 5-HT on the cardiovascular and renal systems and the clinical potential of 5-HT modulation. Doggrell, S.A. Expert opinion on investigational drugs. (2003) [Pubmed]
  14. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Peers, C., Kemp, P.J. Respir. Res. (2001) [Pubmed]
  15. Dual sensory innervation of pulmonary neuroepithelial bodies. Brouns, I., Van Genechten, J., Hayashi, H., Gajda, M., Gomi, T., Burnstock, G., Timmermans, J.P., Adriaensen, D. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  16. Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung. Fu, X.W., Nurse, C.A., Farragher, S.M., Cutz, E. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  17. Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission. Fu, X.W., Nurse, C.A., Cutz, E. Biol. Chem. (2004) [Pubmed]
  18. Selective visualisation of neuroepithelial bodies in vibratome slices of living lung by 4-Di-2-ASP in various animal species. Pintelon, I., De Proost, I., Brouns, I., Van Herck, H., Van Genechten, J., Van Meir, F., Timmermans, J.P., Adriaensen, D. Cell Tissue Res. (2005) [Pubmed]
  19. Vesicular glutamate transporter 2 is expressed in different nerve fibre populations that selectively contact pulmonary neuroepithelial bodies. Brouns, I., Pintelon, I., Van Genechten, J., De Proost, I., Timmermans, J.P., Adriaensen, D. Histochem. Cell Biol. (2004) [Pubmed]
  20. Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein. Castro, C.M., Yang, Y., Zhang, Z., Linnoila, R.I. Lab. Invest. (2000) [Pubmed]
  21. Immunohistochemical demonstration of Clara cell antigen in lung tumors of bronchiolar origin induced by N-nitrosodiethylamine in Syrian golden hamsters. Rehm, S., Takahashi, M., Ward, J.M., Singh, G., Katyal, S.L., Henneman, J.R. Am. J. Pathol. (1989) [Pubmed]
  22. Widespread distribution of bronchopulmonary endocrine cells immunoreactive for calcitonin in the lung of the normal adult rat. Gosney, J.R., Sissons, M.C. Thorax (1985) [Pubmed]
  23. In vitro characteristics of pulmonary neuroendocrine cells isolated from rabbit fetal lung. I. Effects of culture media and nerve growth factor. Cutz, E., Yeger, H., Wong, V., Bienkowski, E., Chan, W. Lab. Invest. (1985) [Pubmed]
  24. Development of pulmonary neuroendocrine cells of fetal hamster in explant culture. Ito, T., Nogawa, H., Udaka, N., Kitamura, H., Kanisawa, M. Lab. Invest. (1997) [Pubmed]
  25. Increased numbers of neuroepithelial bodies (NEB) in lungs of fetal rhesus monkeys following maternal dexamethasone treatment. Dayer, A.M., Kapanci, Y., Rademakers, A., Rusy, L.M., De Mey, J., Will, J.A. Cell Tissue Res. (1985) [Pubmed]
  26. Ultrastructural localization of serotonin in the intrapulmonary neuroepithelial bodies of neonatal rabbits by use of immunoelectron microscopy. Lauweryns, J.M., Van Ranst, L., Verhofstad, A.A. Cell Tissue Res. (1986) [Pubmed]
  27. Long-term induction of beta-CGRP mRNA in rat lungs by allergic inflammation. Tsukiji, J., Sango, K., Udaka, N., Kageyama, H., Ito, T., Saito, H., Horie, H., Inoue, S., Kitamura, H., Hagiwara, E., Ikeda, H., Okubo, T., Ishigatsubo, Y. Life Sci. (2004) [Pubmed]
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