Disease relevance of Unio

• In Unio Internationale Contra Cancrum (UICC) III colorectal cancers, a high level of PBR overexpression correlates with poor prognosis [1].
• CONCLUSIONS: TRAIL-R1 is an independent prognostic factor in R0-resected Unio Internationale Contra Cancrum stage II/III colon cancer [2].
• Na+K+-ATPase activity as a biomarker of toxaphene toxicity in Unio tumidus [3].

High impact information on Unio

• The 220-kDa vitelline coat glycoprotein mediates sperm binding in the polarized egg of Unio elongatulus through O-linked oligosaccharides [4].
• In a previous article, we suggested that gp273, the ligand molecule for sperm-egg interaction in the bivalve mollusk Unio elongatulus has functional carbohydrate epitopes in common with a human zona pellucida glycoprotein, probably ZP3 [5].
• Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus [6].
• We studied three naturally occurring compounds, tannic acid, ellagic acid and gallic acid, for their ability to modulate DNA damage produced by these tannins alone and in the presence of the oxidative stress inducer H(2)O(2), in cells of the digestive gland of mussels (Unio tumidus) [6].
• A 140-kDa glycopeptide from the sperm ligand of the vitelline coat of the freshwater bivalve Unio elongatulus, only contains O-linked oligosaccharide chains and mediates sperm-egg interaction [7].

Biological context of Unio

• Depuration kinetics and persistence of the cyanobacterial toxin microcystin-LR in the freshwater bivalve Unio douglasiae [8].
• Relationship between two oxidative stress biomarkers, malondialdehyde and 8-oxo-7,8-dihydro-2'-deoxyguanosine, in the freshwater bivalve Unio tumidus [9].

Anatomical context of Unio

• A polyclonal antibody against the Unio epitope reacts with the human ZP3 glycoprotein and the Unio ligand binds human spermatozoa in an in vitro assay [10].

Associations of Unio with chemical compounds

• Vitelline coat of Unio elongatulus: III. Glycan chain analysis of the 220- and 180-kD components by means of lectins [11].
• In previous studies we found that sperm binding activity in the vitelline coat of the freshwater bivalve Unio elongatulus is located on the O-linked oligosaccharide chains of gp273, one of the two major components of the extracellular coat, and that fucose plays a key role in this interaction [7].
• Diethylnitrosamine (DENA) and dimethylnitrosamine (DMNA) dissolved in tank water induced neoplasms in bivalve mollusks Unio pictorum [12].
• In this study, the effect of toxaphene (camphechlor) on ATPase activity in the microsomal fraction of the Unio tumidus's digestive gland was determined [3].
• Biological activity of pentachlorophenol on the digestive gland cells of the freshwater mussel Unio tumidus [13].

Gene context of Unio

• In this study, we evaluated the potential of measuring the accumulation rate of a fluorescent model Pgp substrate rhodamine B (RB) in haemolymph, plasma and haemocytes of the freshwater painter's mussel (Unio pictorum) as additional potentially useful compartments [14].
• The enzyme has been shown to specifically interact with the mannose 6-phosphate receptor protein (MPR 300) purified from goat and Unio [15].

References