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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Unio


High impact information on Unio


Biological context of Unio


Anatomical context of Unio


Associations of Unio with chemical compounds

  • Vitelline coat of Unio elongatulus: III. Glycan chain analysis of the 220- and 180-kD components by means of lectins [11].
  • In previous studies we found that sperm binding activity in the vitelline coat of the freshwater bivalve Unio elongatulus is located on the O-linked oligosaccharide chains of gp273, one of the two major components of the extracellular coat, and that fucose plays a key role in this interaction [7].
  • Diethylnitrosamine (DENA) and dimethylnitrosamine (DMNA) dissolved in tank water induced neoplasms in bivalve mollusks Unio pictorum [12].
  • In this study, the effect of toxaphene (camphechlor) on ATPase activity in the microsomal fraction of the Unio tumidus's digestive gland was determined [3].
  • Biological activity of pentachlorophenol on the digestive gland cells of the freshwater mussel Unio tumidus [13].

Gene context of Unio

  • In this study, we evaluated the potential of measuring the accumulation rate of a fluorescent model Pgp substrate rhodamine B (RB) in haemolymph, plasma and haemocytes of the freshwater painter's mussel (Unio pictorum) as additional potentially useful compartments [14].
  • The enzyme has been shown to specifically interact with the mannose 6-phosphate receptor protein (MPR 300) purified from goat and Unio [15].


  1. Up-regulation of the peripheral benzodiazepine receptor during human colorectal carcinogenesis and tumor spread. Maaser, K., Grabowski, P., Oezdem, Y., Krahn, A., Heine, B., Stein, H., Buhr, H., Zeitz, M., Scherübl, H. Clin. Cancer Res. (2005) [Pubmed]
  2. Expression of TRAIL and TRAIL receptors in colon carcinoma: TRAIL-R1 is an independent prognostic parameter. Sträter, J., Hinz, U., Walczak, H., Mechtersheimer, G., Koretz, K., Herfarth, C., Möller, P., Lehnert, T. Clin. Cancer Res. (2002) [Pubmed]
  3. Na+K+-ATPase activity as a biomarker of toxaphene toxicity in Unio tumidus. Pałecz, D., Komuński, R., Gabryelak, T. Toxicology in vitro : an international journal published in association with BIBRA. (2005) [Pubmed]
  4. The 220-kDa vitelline coat glycoprotein mediates sperm binding in the polarized egg of Unio elongatulus through O-linked oligosaccharides. Focarelli, R., Rosati, F. Dev. Biol. (1995) [Pubmed]
  5. Gp273, the ligand molecule for sperm-egg interaction in the bivalve mollusk, Unio elongatulus, binds to and induces acrosome reaction in human spermatozoa through a protein kinase C-dependent pathway. Delle Monache, S., Flori, F., Della Giovampaola, C., Capone, A., La Sala, G.B., Rosati, F., Colonna, R., Tatone, C., Focarelli, R. Biol. Reprod. (2003) [Pubmed]
  6. Antioxidant and pro-oxidant effects of tannins in digestive cells of the freshwater mussel Unio tumidus. Labieniec, M., Gabryelak, T., Falcioni, G. Mutat. Res. (2003) [Pubmed]
  7. A 140-kDa glycopeptide from the sperm ligand of the vitelline coat of the freshwater bivalve Unio elongatulus, only contains O-linked oligosaccharide chains and mediates sperm-egg interaction. Capone, A., Rosati, F., Focarelli, R. Mol. Reprod. Dev. (1999) [Pubmed]
  8. Depuration kinetics and persistence of the cyanobacterial toxin microcystin-LR in the freshwater bivalve Unio douglasiae. Yokoyama, A., Park, H.D. Environ. Toxicol. (2003) [Pubmed]
  9. Relationship between two oxidative stress biomarkers, malondialdehyde and 8-oxo-7,8-dihydro-2'-deoxyguanosine, in the freshwater bivalve Unio tumidus. Charissou, A.M., Cossu-Leguille, C., Vasseur, P. Sci. Total Environ. (2004) [Pubmed]
  10. Carbohydrate-mediated sperm-egg interaction and species specificity: a clue from the Unio elongatulus model. Focarelli, R., La Sala, G.B., Balasini, M., Rosati, F. Cells Tissues Organs (Print) (2001) [Pubmed]
  11. Vitelline coat of Unio elongatulus: III. Glycan chain analysis of the 220- and 180-kD components by means of lectins. Focarelli, R., Leotta, F., Lampariello, R., Rosati, F. Mol. Reprod. Dev. (1995) [Pubmed]
  12. Tumor induction by N-nitroso compounds in bivalve mollusks Unio pictorum. Khudoley, V.V., Syrenko, O.A. Cancer Lett. (1978) [Pubmed]
  13. Biological activity of pentachlorophenol on the digestive gland cells of the freshwater mussel Unio tumidus. Milowska, K., Gabryelak, T., Dudala, J., Labieniec, M., Slobozhanina, E. Z. Naturforsch., C, J. Biosci. (2003) [Pubmed]
  14. Haemolymph as compartment for efficient and non-destructive determination of P-glycoprotein (Pgp) mediated MXR activity in bivalves. Zaja, R., Klobucar, G.I., Sauerborn Klobucar, R., Hackenberger, B.K., Smital, T. Comp. Biochem. Physiol. C Toxicol. Pharmacol. (2006) [Pubmed]
  15. Biochemical and immunological characterization of a glycosylated alpha-fucosidase from the invertebrate Unio: interaction of the enzyme with its in vivo binding partners. Nadimpalli, S.K., Padmanabhan, N., Koduru, S. Protein Expr. Purif. (2004) [Pubmed]
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