Disease relevance of Beluga Whale

• Absence or reduction of carbonic anhydrase II in the red cells of the beluga whale and llama: implications for adaptation to hypoxia [1].
• The beluga whale IL-1beta- and TNF-alpha-encoding sequences were thereafter successfully expressed in Escherichia coli as fusion proteins by using procaryotic expression vectors [2].

High impact information on Beluga Whale

• Primers for the RACE method were synthesized based on the sequence of the DNA of beluga whale corresponding to exon 5 of the human p53 gene, which was determined after amplification of the DNA isolated from the liver from a beluga whale by using a pair of primers for the human sequence [3].
• The metabolic index suggested that PBDEs 47 and 99 accumulate to the same magnitude as PCB 153 (PCB = polychlorinated biphenyl) in ringed seals and beluga whales [4].
• To ascertain the potential for PHAH effects in a cetacean, we characterized an AHR from the beluga whale, Delphinapterus leucas [5].
• However, because of the known genotoxicity of toxaphene and the long lifespan of beluga whales, it cannot be excluded that toxaphene may pose a long-term genetic hazard to the more contaminated whales of this population [6].
• Molecular cloning and characterization of CD4 in an aquatic mammal, the white whale Delphinapterus leucas [7].

Biological context of Beluga Whale

• The identity levels of beluga whale IL-6 nucleic and deduced amino acid sequences with those from these mammalian species ranged from 62.3 to 97.3%, and 42.9 to 95.6%, respectively [8].
• Pathology and toxicology of beluga whales from the St. Lawrence Estuary, Quebec, Canada. Past, present and future [9].

Associations of Beluga Whale with chemical compounds

• Diving and swimming performance of white whales, Delphinapterus leucas: an assessment of plasma lactate and blood gas levels and respiratory rates [10].
• In the present study, images of the brain of a white whale (Beluga) Delphinapterus leucas were scanned in the coronal plane at 119 antero-posterior levels [11].
• Intramuscular Sarcocystis in two beluga whales and an Atlantic white-sided dolphin from the St. Lawrence estuary, Quebec, Canada [12].
• Toxaphene, PCB, DDT, and Chlordane Analyses of Beluga whale blubber [13].
• Bone fluoride concentrations in beluga whales from Canada [14].

Gene context of Beluga Whale

• Lower similarity of the beluga whale p53 gene was also found with those of lower tetrapods, fish and invertebrates [3].
• As yet, no molecular data have been reported for IL-1beta and TNF-alpha of the beluga whale [2].
• The fusion proteins were used to produce beluga whale IL-1beta- and TNF-alpha-specific rabbit antisera [2].
• Given the importance of the cell surface recognition protein, CD4, in immune function, the cloning and characterization of CD4 at the molecular level from an odontocete cetacean, the white whale (Delphinapterus leucas), was carried out [7].
• As yet, no molecular data have been reported for the beluga whale IL-6 [8].

Analytical, diagnostic and therapeutic context of Beluga Whale

• In this study, we cloned and determined the entire beluga whale IL-6-encoding cDNA sequence by reverse transcription-polymerase chain reaction (RT-PCR) sequencing, and analysed its genetic relationship with those from several mammalian species including human, rodent, ruminant, carnivore and other marine species [8].

References