Gene Review:
GRM6 - glutamate receptor, metabotropic 6
Homo sapiens
Synonyms:
CSNB1B, GPRC1F, MGLUR6, Metabotropic glutamate receptor 6, mGlu6, ...
- Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogram. Zeitz, C., van Genderen, M., Neidhardt, J., Luhmann, U.F., Hoeben, F., Forster, U., Wycisk, K., Mátyás, G., Hoyng, C.B., Riemslag, F., Meire, F., Cremers, F.P., Berger, W. Invest. Ophthalmol. Vis. Sci. (2005)
- Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6. Dryja, T.P., McGee, T.L., Berson, E.L., Fishman, G.A., Sandberg, M.A., Alexander, K.R., Derlacki, D.J., Rajagopalan, A.S. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The metabotropic receptor mGluR6 may signal through G(o), but not phosphodiesterase, in retinal bipolar cells. Nawy, S. J. Neurosci. (1999)
- Congenital stationary night blindness associated with mutations in GRM6 encoding glutamate receptor MGluR6. O'Connor, E., Allen, L.E., Bradshaw, K., Boylan, J., Moore, A.T., Trump, D. The British journal of ophthalmology. (2006)
- The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6. Hashimoto, T., Inazawa, J., Okamoto, N., Tagawa, Y., Bessho, Y., Honda, Y., Nakanishi, S. Eur. J. Neurosci. (1997)
- Molecular diversity of glutamate receptors and their physiological functions. Nakanishi, S., Masu, M., Bessho, Y., Nakajima, Y., Hayashi, Y., Shigemoto, R. EXS. (1994)
- Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells. Knöpfel, T., Grandes, P. Cerebellum (2002)
- Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Wright, R.A., Arnold, M.B., Wheeler, W.J., Ornstein, P.L., Schoepp, D.D. Naunyn Schmiedebergs Arch. Pharmacol. (2000)
- G protein coupling profile of mGluR6 and expression of G[alpha] proteins in retinal ON bipolar cells. Tian, L., Kammermeier, P.J. Vis. Neurosci. (2006)
- A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. Bräuner-Osborne, H., Sløk, F.A., Skjaerbaek, N., Ebert, B., Sekiyama, N., Nakanishi, S., Krogsgaard-Larsen, P. J. Med. Chem. (1996)
- Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. Valerio, A., Ferraboli, S., Paterlini, M., Spano, P., Barlati, S. Gene (2001)
- Transmitter concentration at a three-dimensional synapse. Rao-Mirotznik, R., Buchsbaum, G., Sterling, P. J. Neurophysiol. (1998)
- Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus). Kuramoto, T., Maihara, T., Masu, M., Nakanishi, S., Serikawa, T. Genomics (1994)
- 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Gasparini, F., Lingenhöhl, K., Stoehr, N., Flor, P.J., Heinrich, M., Vranesic, I., Biollaz, M., Allgeier, H., Heckendorn, R., Urwyler, S., Varney, M.A., Johnson, E.C., Hess, S.D., Rao, S.P., Sacaan, A.I., Santori, E.M., Veliçelebi, G., Kuhn, R. Neuropharmacology (1999)
- Molecular basis for the differential agonist affinities of group III metabotropic glutamate receptors. Rosemond, E., Wang, M., Yao, Y., Storjohann, L., Stormann, T., Johnson, E.C., Hampson, D.R. Mol. Pharmacol. (2004)
- Glutamate receptors: brain function and signal transduction. Nakanishi, S., Nakajima, Y., Masu, M., Ueda, Y., Nakahara, K., Watanabe, D., Yamaguchi, S., Kawabata, S., Okada, M. Brain Res. Brain Res. Rev. (1998)
- Localization of mGluR6 to dendrites of ON bipolar cells in primate retina. Vardi, N., Duvoisin, R., Wu, G., Sterling, P. J. Comp. Neurol. (2000)