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MeSH Review

Hyperbilirubinemia, Neonatal

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Disease relevance of Hyperbilirubinemia, Neonatal


High impact information on Hyperbilirubinemia, Neonatal

  • Sn-protoporphyrin, in doses (10 mumol/kg body wt) which entirely suppress neonatal hyperbilirubinemia in the experimental animal, leads to a very rapid (approximately 30-60 min) increase in the heme saturation of tryptophan pyrrolase from normal levels of approximately 50-60% to nearly 100% [5].
  • Glucose-6-phosphate dehydrogenase deficiency, the UDP-glucuronosyl transferase 1A1 gene, and neonatal hyperbilirubinemia [6].
  • We asked whether the TA repeat promoter polymorphism in the gene for uridinediphosphoglucuronate glucuronosyltransferase 1 (EC; UDPGT1), associated with benign jaundice in adults (Gilbert syndrome), increases the incidence of neonatal hyperbilirubinemia in G-6-PD deficiency [7].
  • Sn-protoporphyrin IX (SnPP), an inhibitor of heme oxygenase and a potential therapeutic agent for neonatal hyperbilirubinemia, is bound tightly by hemopexin [8].
  • In contrast, I found the same values for serum bilirubin concentrations as determined by these two methods for serum from untreated, "single light", and "double light" treated full-term infants with neonatal hyperbilirubinemia without blood type immunization [9].

Chemical compound and disease context of Hyperbilirubinemia, Neonatal


Biological context of Hyperbilirubinemia, Neonatal


Anatomical context of Hyperbilirubinemia, Neonatal


Gene context of Hyperbilirubinemia, Neonatal


Analytical, diagnostic and therapeutic context of Hyperbilirubinemia, Neonatal


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  24. Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase (Guadalajara)1 159 C --> T (387 Arg --> Cys) deficiency associated with Gilbert syndrome in a Turkish patient. Oner, R., Acar, C., Oner, C., Yenicesu, I., Gümrük, F., Gürgey, A., Altay, C. Pediatric hematology and oncology. (2002) [Pubmed]
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  26. Green light phototherapy in newborn infants with ABO hemolytic disease. Ayyash, H., Hadjigeorgiou, E., Sofatzis, J., Chatziioannou, A., Nicolopoulos, D., Sideris, E. J. Pediatr. (1987) [Pubmed]
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