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MeSH Review

Hyperbilirubinemia, Neonatal

 
 
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Disease relevance of Hyperbilirubinemia, Neonatal

 

High impact information on Hyperbilirubinemia, Neonatal

  • Sn-protoporphyrin, in doses (10 mumol/kg body wt) which entirely suppress neonatal hyperbilirubinemia in the experimental animal, leads to a very rapid (approximately 30-60 min) increase in the heme saturation of tryptophan pyrrolase from normal levels of approximately 50-60% to nearly 100% [5].
  • Glucose-6-phosphate dehydrogenase deficiency, the UDP-glucuronosyl transferase 1A1 gene, and neonatal hyperbilirubinemia [6].
  • We asked whether the TA repeat promoter polymorphism in the gene for uridinediphosphoglucuronate glucuronosyltransferase 1 (EC 2.4.1.17; UDPGT1), associated with benign jaundice in adults (Gilbert syndrome), increases the incidence of neonatal hyperbilirubinemia in G-6-PD deficiency [7].
  • Sn-protoporphyrin IX (SnPP), an inhibitor of heme oxygenase and a potential therapeutic agent for neonatal hyperbilirubinemia, is bound tightly by hemopexin [8].
  • In contrast, I found the same values for serum bilirubin concentrations as determined by these two methods for serum from untreated, "single light", and "double light" treated full-term infants with neonatal hyperbilirubinemia without blood type immunization [9].
 

Chemical compound and disease context of Hyperbilirubinemia, Neonatal

 

Biological context of Hyperbilirubinemia, Neonatal

 

Anatomical context of Hyperbilirubinemia, Neonatal

 

Gene context of Hyperbilirubinemia, Neonatal

 

Analytical, diagnostic and therapeutic context of Hyperbilirubinemia, Neonatal

References

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  5. Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver. Kappas, A., Drummond, G.S., Sardana, M.K. J. Clin. Invest. (1985) [Pubmed]
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  17. Unconjugated and conjugated bilirubin pigments during perinatal development. IV. The influence of breast-feeding on neonatal hyperbilirubinemia. Rubaltelli, F.F. Biol. Neonate (1993) [Pubmed]
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  22. Beta-glucuronidase and hyperbilirubinemia in breast-fed versus formula-fed babies. el-Kholy, M.S., Halim, H.Y., Marzouk, A.H. The Journal of the Egyptian Public Health Association. (1992) [Pubmed]
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  24. Chronic hemolytic anemia associated with glucose 6-phosphate dehydrogenase (Guadalajara)1 159 C --> T (387 Arg --> Cys) deficiency associated with Gilbert syndrome in a Turkish patient. Oner, R., Acar, C., Oner, C., Yenicesu, I., Gümrük, F., Gürgey, A., Altay, C. Pediatric hematology and oncology. (2002) [Pubmed]
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