Disease relevance of Coin Lesion, Pulmonary

• Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN) [1].
• The osteosarcoma and malignant melanoma were treated by below-knee amputation and the gastric cancer by palliative surgery; the pulmonary coin lesion did not respond to cisplatin chemotherapy [2].
• In lung cancer, somatostatin receptor imaging by means of technetium-99m (99mTc)-octreotide scintigraphy has proven useful for characterizing malignancy in solitary pulmonary nodules [3].
• Methods: We performed immunohistochemistry for B7-1, B7-2 and MHC class II antigens using transbronchial lung biopsy specimens obtained from patients with sarcoidosis and normal lung parenchyma obtained by lobectomy for solitary pulmonary nodule as controls [4].

High impact information on Coin Lesion, Pulmonary

• We investigated whether uptake of the thymidine analogue 3-deoxy-3-[(18)F]fluorothymidine ([(18)F]FLT) reflects proliferation in solitary pulmonary nodules (SPNs) [5].
• Metastatic thymoma seen as a solitary pulmonary nodule [6].
• Solitary pulmonary nodules: dynamic enhanced multi-detector row CT study and comparison with vascular endothelial growth factor and microvessel density [7].
• Work-up of the solitary pulmonary nodule. American College of Radiology. ACR Appropriateness Criteria [8].
• CONCLUSION: Adaptive filtration is superior to global filtration in the identification of solitary pulmonary nodules and is superior to no processing in nodules projected over the radiopaque areas of the thorax on digital images [9].

Chemical compound and disease context of Coin Lesion, Pulmonary

• METHODS: A PET scan was carried out before operation using [18F]fluorodeoxyglucose (FDG) in 50 patients with pulmonary coin lesions (diameter 30 mm or less) [10].
• Fractal texture analysis in computer-aided diagnosis of solitary pulmonary nodules [11].
• Several studies have shown the benefit of fluorine-18 fluorodeoxy glucose (FDG) imaging in the differentiation of solitary pulmonary nodules [12].
• This possibility should be kept in mind in the analysis of PET studies of glucose metabolism aimed at differentiating malignant from benign solitary pulmonary nodules [13].
• This study uses Australian data to confirm the accuracy of dedicated sodium iodide (NaI) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in evaluating indeterminate solitary pulmonary nodules (SPNs) and to determine the conditions under which PET could play a cost-effective role in this evaluation [14].

Gene context of Coin Lesion, Pulmonary

• A multicenter trial with a somatostatin analog (99m)Tc depreotide in the evaluation of solitary pulmonary nodules [15].
• BACKGROUND: Severe pulmonary dysfunction has been considered a relative contraindication to surgical resection in patients with solitary pulmonary nodules [16].
• CONCLUSION: Fractal texture characterization provides useful information for the classification of potential solitary pulmonary nodules with CAD algorithms [11].
• Solitary pulmonary nodules: Part II. Evaluation of the indeterminate nodule [17].
• CASE: A 21-year-old male was admitted to our hospital because of a solitary pulmonary nodule that developed 22 months after resection of a tongue mass, small cell variant of PDSS [18].

Analytical, diagnostic and therapeutic context of Coin Lesion, Pulmonary

• Both F-18 FDG PET imaging and Tc 99m depreotide SPECT imaging have a high degree of sensitivity, specificity, overall accuracy, and both PPV and NPV in the management of patients with a solitary pulmonary nodule [19].

References