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MeSH Review


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Disease relevance of Myosarcoma


High impact information on Myosarcoma

  • Treatment of sensitive human myosarcoma cells (KYM-S) with exogenous tumor necrosis factor (r-TNF) resulted in the production of TNF by the cells [5].
  • These data indicate that IGF-II sensitive IR-A is the predominant IR isoform in a variety of myosarcoma cells [6].
  • Prompted by a DGCT in which a subpopulation of cells was desmin positive and in which an erroneous diagnosis of myosarcoma was made, we analyzed the frequency of desmin, myogenin, MyoD1, and muscle-specific actin immunoreactivity in 45 well-characterized GCTs [7].
  • 1. The effect of adenosine analogues and of nucleotides, alone or in combination, on intracellular calcium, accumulation of inositol (1,4,5) trisphosphate (InsP3), and on activation of protein kinase C (PKC) was studied in DDT1 MF2 cells derived from a Syrian hamster myosarcoma [8].
  • Mutant 471 also showed higher cytotoxic activity against human KYM myosarcoma cells and human MIA PaCa-2 pancreatic carcinoma cells [9].

Chemical compound and disease context of Myosarcoma

  • The existence of a tumor necrosis factor (TNF) receptor on KYM human myosarcoma cells was elucidated by Scatchard plot and cross-linking analysis [10].

Gene context of Myosarcoma

  • The cell dynamics of the receptor for tumor necrosis factor (TNF) were examined in TNF-sensitive KYM cells derived from human myosarcoma [11].
  • This report documents the purification, using peptide and whole molecule, and characterization of such autoantibodies from an individual with an unusual, highly MUC1-positive, myosarcoma [12].
  • CONCLUSION: High-molecular-weight caldesmon and myogenin are useful for differentiating urogenital PMTs from myosarcomas [13].


  1. Comparison of bleomycin and peplomycin toxicity on clonogenic tumor cells from various human tumors. Neumann, H.A., Runge, H.M., Fiebig, H.H., Engelhardt, R., Löhr, G.W. J. Cancer Res. Clin. Oncol. (1986) [Pubmed]
  2. A case report of malignant mesenchymoma with discussion of musculoskeletal tumor staging: the Enneking system. DePaolo, C.J., Foster, W.S., Dabezies, E.J., D'Ambrosia, R.D. Orthopedics. (1988) [Pubmed]
  3. Results obtained with fractionated ifosfamide massive-dose treatment in generalized malignant tumours. Brühl, P., Günther, U., Hoefer-Janker, H., Hüls, W., Scheef, W., Vahlensieck, W. International journal of clinical pharmacology and biopharmacy. (1976) [Pubmed]
  4. Cytotoxic effects of some animal and vegetable extracts and some chemicals on liver and colon carcinoma and myosarcoma. Bayazit, V. Saudi medical journal. (2004) [Pubmed]
  5. Induction of synthesis of tumor necrosis factor in human and murine cell lines by exogenous recombinant human tumor necrosis factor. Niitsu, Y., Watanabe, N., Neda, H., Yamauchi, N., Maeda, M., Sone, H., Kuriyama, H. Cancer Res. (1988) [Pubmed]
  6. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Sciacca, L., Mineo, R., Pandini, G., Murabito, A., Vigneri, R., Belfiore, A. Oncogene (2002) [Pubmed]
  7. Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. Folpe, A.L., Weiss, S.W., Fletcher, C.D., Gown, A.M. Mod. Pathol. (1998) [Pubmed]
  8. Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells. Fredholm, B.B., Assender, J.W., Irenius, E., Kodama, N., Saito, N. Cell. Mol. Neurobiol. (2003) [Pubmed]
  9. Characterization of a novel human tumor necrosis factor-alpha mutant with increased cytotoxic activity. Masegi, T., Kato, A., Kitai, K., Fukuoka, M., Ogawa, H., Ichikawa, Y., Nakamura, S., Watanabe, N., Niitsu, Y. Jpn. J. Cancer Res. (1995) [Pubmed]
  10. Analysis of the TNF receptor on KYM cells by binding assay and affinity cross-linking. Niitsu, Y., Watanabe, N., Sone, H., Neda, H., Yamauchi, N., Maeda, M., Urushizaki, I. Journal of biological response modifiers. (1988) [Pubmed]
  11. Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line. Watanabe, N., Kuriyama, H., Sone, H., Neda, H., Yamauchi, N., Maeda, M., Niitsu, Y. J. Biol. Chem. (1988) [Pubmed]
  12. Malignancy-induced autoimmunity to MUC1: initial antibody characterization. Graves, C.R., Robertson, J.F., Murray, A., Price, M.R., Chapman, C.J. J. Pept. Res. (2005) [Pubmed]
  13. Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract. Watanabe, K., Baba, K., Saito, A., Hoshi, N., Suzuki, T. Arch. Pathol. Lab. Med. (2001) [Pubmed]
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