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Chemical Compound Review

PEPLOMYCIN     [(2R,3S,4S,5R,6R)-2- [(2S,3S,4S,5S,6S)-2-[2...

Synonyms: Pepleomycin, Peplomycina, Peplomycine, Peplomycinum, Bleomycin PEP, ...
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Disease relevance of Pepleomycin


Psychiatry related information on Pepleomycin

  • Resting salivary flow rate (SFR) of the combined therapy group was decreased to half the initial rate, and a 20% decrease of SFR was seen in the PLM group [6].

High impact information on Pepleomycin

  • RESULTS: Rats given PEP-CH had significantly higher peplomycin levels in the regional lymph nodes and the injection site than rats given aqueous solution [1].
  • Endoscopic local injection of a new drug-delivery format of peplomycin for superficial esophageal cancer: a pilot study [1].
  • The lethal effects of bleomycin and its derivative, peplomycin, were determined for HeLa S3 cells grown in multicell spheroids cocultured with human diploid fibroblasts [7].
  • Combination of lidocaine (3 to 6 mM) and moderate hyperthermia (40 and 41 degrees) greatly enhanced peplomycin cytotoxicity, although these doses of lidocaine alone were ineffective at 37 degrees, and the temperatures alone enhanced the cytotoxicity only slightly [2].
  • The enhancing effect of lidocaine on peplomycin-induced cell killing was found to increase as pH increased within the range of 7.0 to 8.0 [2].

Chemical compound and disease context of Pepleomycin


Biological context of Pepleomycin


Anatomical context of Pepleomycin


Associations of Pepleomycin with other chemical compounds


Gene context of Pepleomycin


Analytical, diagnostic and therapeutic context of Pepleomycin


  1. Endoscopic local injection of a new drug-delivery format of peplomycin for superficial esophageal cancer: a pilot study. Hagiwara, A., Takahashi, T., Kojima, O., Kitamura, K., Sakakura, C., Shoubayashi, S., Osaki, K., Iwamoto, A., Lee, M., Fujita, K. Gastroenterology (1993) [Pubmed]
  2. Selective enhancement of the cytotoxicity of the bleomycin derivative, peplomycin, by local anesthetics alone and combined with hyperthermia. Mizuno, S., Ishida, A. Cancer Res. (1982) [Pubmed]
  3. A preliminary report on the treatment of lung cancer with pepleomycin. Homma, H., Niitani, H. Cancer Treat. Rev. (1980) [Pubmed]
  4. The in vitro and in vivo antitumor effects of pepleomycin alone or in combination with radiation. Sakamoto, K., Komatsu, K., Matsumoto, Y. Radiat. Res. (1985) [Pubmed]
  5. Reduced pulmonary toxicity of peplomycin in a new drug-delivery system. Hagiwara, A., Takahashi, T., Ueda, T., Torii, T. Anticancer Drug Des. (1988) [Pubmed]
  6. Gustatory impairment and salivary gland pathophysiology in relation to oral cancer treatment. Tomita, Y., Osaki, T. International journal of oral and maxillofacial surgery. (1990) [Pubmed]
  7. Lethal effect of bleomycin and peplomycin on HeLa cells in multicell tumor spheroids. Sasaki, T., Yamamoto, M., Kuwahara, K. Cancer Res. (1984) [Pubmed]
  8. Cisplatin, vindesine, pepleomycin and concurrent radiation therapy following esophagectomy with lymph adenectomy for patients with an esophageal carcinoma. Saito, T., Shigemitsu, Y., Kinoshita, T., Shimoda, K., Abe, T., Nakamura, A., Chikuba, K., Kobayashi, M. Oncology (1993) [Pubmed]
  9. Chemotherapy administered using two-route infusion of cisplatin and sodium thiosulfate and intravenous infusion of vinblastine and peplomycin in patients with oral cancer. Wada, T., Harada, M., Morita, N., Oomata, T., Koizumi, T., Kawashima, T., Sakamoto, T. Clinical therapeutics. (1995) [Pubmed]
  10. Effects of preoperative radiotherapy on rectal cancer. Preliminary report on combining radiation with intratumor injections of peplomycin and bromodeoxyuridine. Sarashina, H., Todoroki, T., Orii, K., Ohara, K., Otsu, H., Iwasaki, Y. Dis. Colon Rectum (1990) [Pubmed]
  11. A novel multidrug resistance in cultured leukemia and lymphoma cells detected by a monoclonal antibody to 85-kDa protein, MRK20. Ohtsu, T., Ishida, Y., Tobinai, K., Minato, K., Hamada, H., Ohkochi, E., Tsuruo, T., Shimoyama, M. Jpn. J. Cancer Res. (1989) [Pubmed]
  12. Chemosensitivity testing of human lung cancer tissues using the succinate dehydrogenase inhibition test. Mitsudomi, T., Kaneko, S., Tateishi, M., Yano, T., Ishida, T., Kohnoe, S., Maehara, Y., Sugimachi, K. Anticancer Res. (1990) [Pubmed]
  13. Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations. Kawanishi, S., Oikawa, S., Kawanishi, M., Sugiyama, H., Saito, I., Strekowski, L., Wilson, W.D. Biochemistry (2000) [Pubmed]
  14. Peplomycin. DNA breakage and in vivo inhibition of DNA polymerases and ligase from human normal and leukemic cells. Saulier, B., Prigent, C., Boutelier, R., David, J.C. Carcinogenesis (1988) [Pubmed]
  15. Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide. Hiraku, Y., Oikawa, S., Kuroki, K., Sugiyama, H., Saito, I., Kawanishi, S. Biochem. Pharmacol. (2001) [Pubmed]
  16. Effect of chemotherapy on natural-killer activity and antibody-dependent cell-mediated cytotoxicity in carcinoma of the lung. Saijo, N., Shimizu, E., Shibuya, M., Irimajiri, N., Takizawa, T., Eguchi, K., Shinkai, T., Tominaga, K., Shimabukuro, Z., Taniguchi, T., Hoshi, A. Br. J. Cancer (1982) [Pubmed]
  17. A peplomycin-supersensitive cell line lacking activation of poly(adenosine diphosphate ribose) synthetase by peplomycin. Ozawa, S., Suzuki, H., Yamaki, H., Nishimura, T., Tanaka, N. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  18. Micronucleus formation in different lymphocyte subpopulations in peplomycin-treated and control cultures. Slavutsky, I., Knuutila, S. Mutat. Res. (1989) [Pubmed]
  19. Enzyme immunoassay for pepleomycin, a new bleomycin analog. Fujiwara, K., Yasuno, M., Kitagawa, T. Cancer Res. (1981) [Pubmed]
  20. Retroperitoneal seminoma with simultaneous occurrence in the prostate. Arai, Y., Watanabe, J., Kounami, T., Tomoyoshi, T. J. Urol. (1988) [Pubmed]
  21. Suppression by anticancer agents of reactive oxygen generation from polymorphonuclear leukocytes. Ueta, E., Osaki, T. Free Radic. Res. (1996) [Pubmed]
  22. Metallothionein-mediated resistance to multiple drugs can be induced by several anticancer drugs in mice. Okazaki, Y., Miura, N., Satoh, M., Imura, N., Naganuma, A. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  23. Antitumor efficacy of seventeen anticancer drugs in human breast cancer xenograft (MX-1) transplanted in nude mice. Inoue, K., Fujimoto, S., Ogawa, M. Cancer Chemother. Pharmacol. (1983) [Pubmed]
  24. Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II). Ikeda, S., Ozaki, K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  25. Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y., Asanuma, F., Ando, N., Ozawa, S., Kitagawa, Y., Kitajima, M. Oncol. Rep. (2001) [Pubmed]
  26. Targeted killing of squamous carcinoma cells by a monoclonal antibody-peplomycin conjugate which recognizes the EGF receptor. Osaku, M., Ueda, M., Ando, N., Shinozawa, Y., Hirota, N., Shimizu, N., Abe, O. Anticancer Res. (1991) [Pubmed]
  27. Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors. Nishimura, C., Nishimura, T., Tanaka, N., Suzuki, H. J. Antibiot. (1987) [Pubmed]
  28. X-ray absorption spectroscopic investigation of Fe(II)-peplomycin and peplomycin derivatives: the effect of axial ligation on Fe-pyrimidine back-bonding. Wasinger, E.C., Zaleski, L., Hedman, B., Hodgson, K.O., Solomon, E.I. J. Biol. Inorg. Chem. (2002) [Pubmed]
  29. Xanthogranulomatous transformation of metastatic testicular tumor. Ueda, T., Kawano, H. Urology (1983) [Pubmed]
  30. Experimental and clinical evaluation by flow cytometry for the mechanism of combination therapy (cisplatin and peplomycin). Kawamoto, K., Wada, Y., Kumazawa, H., Yamashita, T., Kumazawa, T., Matsumura, H. Cytometry. (1992) [Pubmed]
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