Disease relevance of Lumbosacral Plexus

• Enoxaparin associated with psoas hematoma and lumbar plexopathy after lumbar plexus block [1].
• Cardiac arrest after injection of ropivacaine for posterior lumbar plexus blockade [2].
• Lumbar plexus blockade with ropivacaine for postoperative pain management in elderly patients undergoing urologic surgeries [3].

High impact information on Lumbosacral Plexus

• Unilateral analgesia following injection of fentanyl into the lumbosacral plexus [4].
• Accumulating evidence, however, suggests that the far-field potentials of P17 and P31 arise from the distal portion of the sacral plexus and brainstem respectively [5].
• We have examined the safety, tolerability, and efficacy of two intravenous doses of magnesium sulfate in 12 patients with neuropathic pain due to malignant infiltration of the brachial or lumbosacral plexus [6].
• However, lumbar plexus block (three-in-one) with continuous bupivacaine infusion was most effective, and, although it constitutes an added technique, its scant complications and easy performance make its use advisable [7].
• In this case series, patients were sedated with propofol alone and had a lumbar plexus block performed at the end of surgery [8].

Chemical compound and disease context of Lumbosacral Plexus

• Postoperative pain treatment after open knee surgery: continuous lumbar plexus block with bupivacaine versus epidural morphine [9].

Biological context of Lumbosacral Plexus

• Ropivacaine plasma concentrations are similar during continuous lumbar plexus blockade using two techniques: pharmacokinetics or pharmacodynamics [10]?
• The lumbosacral plexus in specific Hox gene mutant mice originating from C57bl/60, i.e., Hoxa9 +/+, +/- and -/- genotypes (10 specimens of each), were dissected minutely and detailed examinations were made of the eight nerves in the plexus and the lowest intercostal nerve [11].

Anatomical context of Lumbosacral Plexus

• Posterior approach to the lumbar plexus combined with a sciatic nerve block using lidocaine [12].
• It is concluded that when used for a continuous block of the lumbar plexus after knee-joint surgery, bupivacaine in a concentration of 0.125% offers the same pain relief as a concentration of 0.25%, and the risk of toxic reactions is reduced [13].
• The goal of this prospective randomized study was to assess the extension of the "three-in-one" paravascular lumbar plexus block after femoral nerve stimulation and injection of 20 vs. 40 ml mepivacaine 10 mg/ml [14].
• Measurements of carbon dioxide production were carried out on 20 patients undergoing arthroplastic operation of the hip joint, under halothane anaesthesia supplemented with lumbar plexus block [15].

Associations of Lumbosacral Plexus with chemical compounds

• A case of lumbar plexus neuropathy occurring in the setting of heparin therapy is reported [16].
• Patients scheduled to undergo knee arthroscopy were randomized to receive a GA (midazolam, fentanyl, propofol, N(2)O/O(2)/desflurane via laryngeal mask airway) or lumbar plexus/sciatic block (PNBs; 2-chloroprocaine) [17].
• Ropivacaine plasma concentrations are similar during continuous lumbar plexus blockade using the anterior three-in-one and the posterior psoas compartment techniques [18].
• Plasma prilocaine and mepivacaine concentrations after combined lumbosacral plexus block [19].
• Prilocaine in lumbosacral plexus block--general efficacy and comparison of nerve stimulation amplitude [20].

Gene context of Lumbosacral Plexus

• Measurements were made between the branches of the lumbar plexus and various bone landmarks such as the midline vertebral bodies, supracristal plane--a horizontal line connecting the superior-most aspect of the left and right iliac crests approximating the LA-5 vertebrae--and anterior superior iliac spine (ASIS) [21].

Analytical, diagnostic and therapeutic context of Lumbosacral Plexus

• This study compares bupivacaine and ropivacaine to determine the optimal long-acting local anaesthetic for lumbar plexus and sciatic nerve block in patients undergoing total knee arthroplasty [22].
• CONCLUSION: In elderly patients, lumbar plexus blockade with ropivacaine can be a simple, safe and effective analgesic technique especially in the early postoperative period after urologic surgeries with flank incision [3].

References