The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Copper-64     copper

Synonyms: AC1L2Y45, 13981-25-4, Copper, isotope of mass 64
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of copper


High impact information on copper


Biological context of copper


Anatomical context of copper


Associations of copper with other chemical compounds


Gene context of copper

  • Bombesin (BN) is a tetradecapeptide that binds with high affinity to GRPR and can be radiolabeled with the positron-emitter, copper-64 ((64)Cu) for imaging with positron-emission tomography (PET) [15].
  • Several lipophilic cationic copper(I) bis(diphosphine) complexes labelled with copper-64 have been synthesised and evaluated in vitro as substrates for Pgp [16].

Analytical, diagnostic and therapeutic context of copper


  1. RadioimmunoPET: detection of colorectal carcinoma with positron-emitting copper-64-labeled monoclonal antibody. Philpott, G.W., Schwarz, S.W., Anderson, C.J., Dehdashti, F., Connett, J.M., Zinn, K.R., Meares, C.F., Cutler, P.D., Welch, M.J., Siegel, B.A. J. Nucl. Med. (1995) [Pubmed]
  2. Determination of zinc-65, copper-64 and sulphur-35 labelled rat hepatoma tissue culture metallothioneins by high-performance liquid chromatography with on-line radioactivity detection. Steinebach, O.M., Wolterbeek, H.T. J. Chromatogr. (1993) [Pubmed]
  3. Copper-64 metabolism in two patients with non-Wilsonian movement disorders and copper deficiency. Wierzbicki, A.S., Patel, N., Evans, K., Lascelles, P.T. J. Neurol. Sci. (1993) [Pubmed]
  4. Neonatal and adult copper-64 metabolism in the pig and the possible relationship between the ontogeny of copper metabolism and Wilson's disease. Bingle, C.D., Srai, S.K., Whiteley, G.S., Epstein, O. Biol. Neonate (1988) [Pubmed]
  5. Comparative uptakes and biodistributions of internalizing vs. noninternalizing copper-64 radioimmunoconjugates in cell and animal models of colon cancer. Bryan, J.N., Jia, F., Mohsin, H., Sivaguru, G., Miller, W.H., Anderson, C.J., Henry, C.J., Lewis, M.R. Nucl. Med. Biol. (2005) [Pubmed]
  6. High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Wu, A.M., Yazaki, P.J., Tsai, S., Nguyen, K., Anderson, A.L., McCarthy, D.W., Welch, M.J., Shively, J.E., Williams, L.E., Raubitschek, A.A., Wong, J.Y., Toyokuni, T., Phelps, M.E., Gambhir, S.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. Comparative in vivo behavior studies of cyclen-based copper-64 complexes: regioselective synthesis, X-ray structure, radiochemistry, log P, and biodistribution. Yoo, J., Reichert, D.E., Welch, M.J. J. Med. Chem. (2004) [Pubmed]
  8. In vitro and in vivo evaluation of copper-64-octreotide conjugates. Anderson, C.J., Pajeau, T.S., Edwards, W.B., Sherman, E.L., Rogers, B.E., Welch, M.J. J. Nucl. Med. (1995) [Pubmed]
  9. Uptake and efflux of copper-64 in Menkes'-disease and normal continuous lymphoid cell lines. Herd, S.M., Camakaris, J., Christofferson, R., Wookey, P., Danks, D.M. Biochem. J. (1987) [Pubmed]
  10. In vivo transchelation of copper-64 from TETA-octreotide to superoxide dismutase in rat liver. Bass, L.A., Wang, M., Welch, M.J., Anderson, C.J. Bioconjug. Chem. (2000) [Pubmed]
  11. Treatment of Wilson's disease with zinc: X. Intestinal metallothionein induction. Yuzbasiyan-Gurkan, V., Grider, A., Nostrant, T., Cousins, R.J., Brewer, G.J. J. Lab. Clin. Med. (1992) [Pubmed]
  12. Radiolabelled leukocytes for imaging inflammation: how radiochemistry affects clinical use. Ballinger, J.R., Gnanasegaran, G. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceu... (2005) [Pubmed]
  13. Altered copper metabolism in cultured cells from human Menkes' syndrome and mottled mouse mutants. Camakaris, J., Danks, D.M., Ackland, L., Cartwright, E., Borger, P., Cotton, R.G. Biochem. Genet. (1980) [Pubmed]
  14. Comparative dosimetry of copper-64 and yttrium-90-labeled somatostatin analogs in a tumor-bearing rat model. Lewis, J.S., Laforest, R., Lewis, M.R., Anderson, C.J. Cancer Biother. Radiopharm. (2000) [Pubmed]
  15. MicroPET Imaging of Breast Cancer Using Radiolabeled Bombesin Analogs Targeting the Gastrin-releasing Peptide Receptor. Parry, J.J., Andrews, R., Rogers, B.E. Breast Cancer Res. Treat. (2007) [Pubmed]
  16. Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET. Lewis, J.S., Dearling, J.L., Sosabowski, J.K., Zweit, J., Carnochan, P., Kelland, L.R., Coley, H.M., Blower, P.J. European journal of nuclear medicine. (2000) [Pubmed]
  17. Subcellular localization of radiolabeled somatostatin analogues: implications for targeted radiotherapy of cancer. Wang, M., Caruano, A.L., Lewis, M.R., Meyer, L.A., VanderWaal, R.P., Anderson, C.J. Cancer Res. (2003) [Pubmed]
  18. Dosimetric evaluation of copper-64 in copper-67-2IT-BAT-Lym-1 for radioimmunotherapy. Shen, S., DeNardo, G.L., DeNardo, S.J., Salako, Q., Morris, G., Banks, D., Yuan, A., DeNardo, D.A. J. Nucl. Med. (1996) [Pubmed]
  19. Optimization of labeling and metabolite analysis of copper-64-labeled azamacrocyclic chelators by radio-LC-MS. Boswell, C.A., McQuade, P., Weisman, G.R., Wong, E.H., Anderson, C.J. Nucl. Med. Biol. (2005) [Pubmed]
  20. Copper chelation chemistry and its role in copper radiopharmaceuticals. Wadas, T.J., Wong, E.H., Weisman, G.R., Anderson, C.J. Curr. Pharm. Des. (2007) [Pubmed]
WikiGenes - Universities