Gene Review:
Atp7a - ATPase, Cu++ transporting, alpha polypeptide
Mus musculus
Synonyms:
Blo, Copper pump 1, Copper-transporting ATPase 1, MNK, Menkes disease-associated protein homolog, ...
- Metallothionein messenger RNA regulation in the mottled mouse and Menkes kinky hair syndrome. Packman, S., Palmiter, R.D., Karin, M., O'Toole, C. J. Clin. Invest. (1987)
- Spontaneous aortic aneurysms in blotchy mice. Andrews, E.J., White, W.J., Bullock, L.P. Am. J. Pathol. (1975)
- Retinal localization and copper-dependent relocalization of the Wilson and Menkes disease proteins. Krajacic, P., Qian, Y., Hahn, P., Dentchev, T., Lukinova, N., Dunaief, J.L. Invest. Ophthalmol. Vis. Sci. (2006)
- Trace metal metabolism in cultured skin fibroblasts of the mottled mouse: response to metallothionein inducers. Packman, S., O'Toole, C. Pediatr. Res. (1984)
- Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Steveson, T.C., Ciccotosto, G.D., Ma, X.M., Mueller, G.P., Mains, R.E., Eipper, B.A. Endocrinology (2003)
- Biochemical study on the critical period for treatment of the mottled brindled mouse. Fujii, T., Ito, M., Tsuda, H., Mikawa, H. J. Neurochem. (1990)
- Hypothalamic self-stimulation and operant activity in the mottled mutant mouse. Cazala, P., Cardo, B. Brain Res. Bull. (1977)
- Deletion of the promoter region in the Atp7a gene of the mottled dappled mouse. Levinson, B., Packman, S., Gitschier, J. Nat. Genet. (1997)
- A murine model of Menkes disease reveals a physiological function of metallothionein. Kelly, E.J., Palmiter, R.D. Nat. Genet. (1996)
- The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene. Wu, J., Forbes, J.R., Chen, H.S., Cox, D.W. Nat. Genet. (1994)
- Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice. Mercer, J.F., Grimes, A., Ambrosini, L., Lockhart, P., Paynter, J.A., Dierick, H., Glover, T.W. Nat. Genet. (1994)
- Propranolol stimulates the crosslinking of matrix components in skin from the aneurysm-prone blotchy mouse. Brophy, C.M., Tilson, J.E., Tilson, M.D. J. Surg. Res. (1989)
- Brindled mottled mouse: morphological changes of brain and visceral organs in hemizygous males following copper supplementation. Suzuki, K., Nagara, H. Acta Neuropathol. (1981)
- Long-term clinical experience with a topical retinoid. Thorne, E.G. Br. J. Dermatol. (1992)
- Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases. Qian, Y., Tiffany-Castiglioni, E., Harris, E.D. Mol. Cell. Biochem. (1998)
- Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice. The yellow mouse syndrome. Wolff, G.L., Roberts, D.W., Galbraith, D.B. J. Hered. (1986)
- Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation. Payne, A.S., Kelly, E.J., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters. Kuo, Y.M., Gitschier, J., Packman, S. Hum. Mol. Genet. (1997)
- Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease. Reed, V., Boyd, Y. Hum. Mol. Genet. (1997)
- Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b. Moore, S.D., Cox, D.W. Nephron (2002)
- Intracellular localization and loss of copper responsiveness of Mnk, the murine homologue of the Menkes protein, in cells from blotchy (Mo blo) and brindled (Mo br) mouse mutants. La Fontaine, S., Firth, S.D., Lockhart, P.J., Brooks, H., Camakaris, J., Mercer, J.F. Hum. Mol. Genet. (1999)
- Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Schlief, M.L., West, T., Craig, A.M., Holtzman, D.M., Gitlin, J.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Inhibition of aortic aneurysm development in blotchy mice by beta adrenergic blockade independent of altered lysyl oxidase activity. Moursi, M.M., Beebe, H.G., Messina, L.M., Welling, T.H., Stanley, J.C. J. Vasc. Surg. (1995)
- A Menkes P-type ATPase involved in copper homeostasis in the central nervous system of the rat. Qian, Y., Tiffany-Castiglioni, E., Harris, E.D. Brain Res. Mol. Brain Res. (1997)
- Hepatic metallothionein synthesis in neonatal Mottled-Brindled mutant mice. Piletz, J.E., Herschman, H.R. Biochem. Genet. (1983)
- Experimental cerebral aneurysms in the female heterozygous Blotchy mouse. Coutard, M. International journal of experimental pathology. (1999)
- Age-associated activation of epigenetically repressed genes in the mouse. Bennett-Baker, P.E., Wilkowski, J., Burke, D.T. Genetics (2003)
- Coordinate control and variation in X-linked gene expression among female mice. Greenwood, A.D., Southard-Smith, E.M., Galecki, A.T., Burke, D.T. Mamm. Genome (1997)
- Analysis of Mnk, the murine homologue of the locus for Menkes disease, in normal and mottled (Mo) mice. George, A.M., Reed, V., Glenister, P., Chelly, J., Tümer, Z., Horn, N., Monaco, A.P., Boyd, Y. Genomics (1994)
- Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease. Grimes, A., Hearn, C.J., Lockhart, P., Newgreen, D.F., Mercer, J.F. Hum. Mol. Genet. (1997)