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Chemical Compound Review

Clofarex     (2R,3R,4S,5R)-5-(6-amino-2- chloro-purin-9...

Synonyms: Evoltra, Clolar, CAFdA, Clofarabine, clofarabina, ...
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Disease relevance of Clofarabine


High impact information on Clofarabine


Chemical compound and disease context of Clofarabine


Biological context of Clofarabine


Anatomical context of Clofarabine


Associations of Clofarabine with other chemical compounds


Gene context of Clofarabine

  • The interactions between 2-Cl and its surrounding hydrophobic residues contribute to the high catalytic efficiency of dCK for clofarabine [17].
  • This loss is reduced or absent in clofarabine-treated FLT3 mutant cells [18].

Analytical, diagnostic and therapeutic context of Clofarabine


  1. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Faderl, S., Gandhi, V., O'Brien, S., Bonate, P., Cortes, J., Estey, E., Beran, M., Wierda, W., Garcia-Manero, G., Ferrajoli, A., Estrov, Z., Giles, F.J., Du, M., Kwari, M., Keating, M., Plunkett, W., Kantarjian, H. Blood (2005) [Pubmed]
  2. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Kantarjian, H., Gandhi, V., Cortes, J., Verstovsek, S., Du, M., Garcia-Manero, G., Giles, F., Faderl, S., O'Brien, S., Jeha, S., Davis, J., Shaked, Z., Craig, A., Keating, M., Plunkett, W., Freireich, E.J. Blood (2003) [Pubmed]
  3. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Faderl, S., Verstovsek, S., Cortes, J., Ravandi, F., Beran, M., Garcia-Manero, G., Ferrajoli, A., Estrov, Z., O'Brien, S., Koller, C., Giles, F.J., Wierda, W., Kwari, M., Kantarjian, H.M. Blood (2006) [Pubmed]
  4. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. Kantarjian, H.M., Gandhi, V., Kozuch, P., Faderl, S., Giles, F., Cortes, J., O'Brien, S., Ibrahim, N., Khuri, F., Du, M., Rios, M.B., Jeha, S., McLaughlin, P., Plunkett, W., Keating, M. J. Clin. Oncol. (2003) [Pubmed]
  5. Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment. Gandhi, V., Plunkett, W., Bonate, P.L., Du, M., Nowak, B., Lerner, S., Keating, M.J. Clin. Cancer Res. (2006) [Pubmed]
  6. Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Gandhi, V., Kantarjian, H., Faderl, S., Bonate, P., Du, M., Ayres, M., Rios, M.B., Keating, M.J., Plunkett, W. Clin. Cancer Res. (2003) [Pubmed]
  7. Clofarabine and nelarabine: two new purine nucleoside analogs. Gandhi, V., Plunkett, W. Current opinion in oncology. (2006) [Pubmed]
  8. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Jeha, S., Gaynon, P.S., Razzouk, B.I., Franklin, J., Kadota, R., Shen, V., Luchtman-Jones, L., Rytting, M., Bomgaars, L.R., Rheingold, S., Ritchey, K., Albano, E., Arceci, R.J., Goldman, S., Griffin, T., Altman, A., Gordon, B., Steinherz, L., Weitman, S., Steinherz, P. J. Clin. Oncol. (2006) [Pubmed]
  9. Clofarabine: in pediatric patients with acute lymphoblastic leukemia. Curran, M.P., Perry, C.M. Paediatric drugs. (2005) [Pubmed]
  10. Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Kline, J.P., Larson, R.A. Expert opinion on pharmacotherapy. (2005) [Pubmed]
  11. Plasma and cerebrospinal fluid pharmacokinetics of clofarabine in nonhuman primates. Berg, S.L., Bonate, P.L., Nuchtern, J.G., Dauser, R., McGuffey, L., Bernacky, B., Blaney, S.M. Clin. Cancer Res. (2005) [Pubmed]
  12. Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance. Månsson, E., Flordal, E., Liliemark, J., Spasokoukotskaja, T., Elford, H., Lagercrantz, S., Eriksson, S., Albertioni, F. Biochem. Pharmacol. (2003) [Pubmed]
  13. The distribution, metabolism, and elimination of clofarabine in rats. Bonate, P.L., Arthaud, L., Stuhler, J., Yerino, P., Press, R.J., Rose, J.Q. Drug Metab. Dispos. (2005) [Pubmed]
  14. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Robak, T., Lech-Maranda, E., Korycka, A., Robak, E. Current medicinal chemistry (2006) [Pubmed]
  15. In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Beesley, A.H., Palmer, M.L., Ford, J., Weller, R.E., Cummings, A.J., Freitas, J.R., Firth, M.J., Perera, K.U., de Klerk, N.H., Kees, U.R. Br. J. Haematol. (2007) [Pubmed]
  16. Prognostic factors and therapeutic options for relapsed or refractory acute myeloid leukemia. Ferrara, F., Palmieri, S., Mele, G. Haematologica (2004) [Pubmed]
  17. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Zhang, Y., Secrist, J.A., Ealick, S.E. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  18. Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine. Seedhouse, C., Grundy, M., Shang, S., Ronan, J., Pimblett, H., Russell, N., Pallis, M. Clin. Cancer Res. (2009) [Pubmed]
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