The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Clofarex     (2R,3R,4S,5R)-5-(6-amino-2- chloro-purin-9...

Synonyms: Evoltra, Clolar, CAFdA, Clofarabine, clofarabina, ...
 
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Clofarabine

 

High impact information on Clofarabine

 

Chemical compound and disease context of Clofarabine

 

Biological context of Clofarabine

 

Anatomical context of Clofarabine

 

Associations of Clofarabine with other chemical compounds

 

Gene context of Clofarabine

  • The interactions between 2-Cl and its surrounding hydrophobic residues contribute to the high catalytic efficiency of dCK for clofarabine [17].
  • This loss is reduced or absent in clofarabine-treated FLT3 mutant cells [18].
 

Analytical, diagnostic and therapeutic context of Clofarabine

References

  1. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Faderl, S., Gandhi, V., O'Brien, S., Bonate, P., Cortes, J., Estey, E., Beran, M., Wierda, W., Garcia-Manero, G., Ferrajoli, A., Estrov, Z., Giles, F.J., Du, M., Kwari, M., Keating, M., Plunkett, W., Kantarjian, H. Blood (2005) [Pubmed]
  2. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Kantarjian, H., Gandhi, V., Cortes, J., Verstovsek, S., Du, M., Garcia-Manero, G., Giles, F., Faderl, S., O'Brien, S., Jeha, S., Davis, J., Shaked, Z., Craig, A., Keating, M., Plunkett, W., Freireich, E.J. Blood (2003) [Pubmed]
  3. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Faderl, S., Verstovsek, S., Cortes, J., Ravandi, F., Beran, M., Garcia-Manero, G., Ferrajoli, A., Estrov, Z., O'Brien, S., Koller, C., Giles, F.J., Wierda, W., Kwari, M., Kantarjian, H.M. Blood (2006) [Pubmed]
  4. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. Kantarjian, H.M., Gandhi, V., Kozuch, P., Faderl, S., Giles, F., Cortes, J., O'Brien, S., Ibrahim, N., Khuri, F., Du, M., Rios, M.B., Jeha, S., McLaughlin, P., Plunkett, W., Keating, M. J. Clin. Oncol. (2003) [Pubmed]
  5. Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment. Gandhi, V., Plunkett, W., Bonate, P.L., Du, M., Nowak, B., Lerner, S., Keating, M.J. Clin. Cancer Res. (2006) [Pubmed]
  6. Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias. Gandhi, V., Kantarjian, H., Faderl, S., Bonate, P., Du, M., Ayres, M., Rios, M.B., Keating, M.J., Plunkett, W. Clin. Cancer Res. (2003) [Pubmed]
  7. Clofarabine and nelarabine: two new purine nucleoside analogs. Gandhi, V., Plunkett, W. Current opinion in oncology. (2006) [Pubmed]
  8. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Jeha, S., Gaynon, P.S., Razzouk, B.I., Franklin, J., Kadota, R., Shen, V., Luchtman-Jones, L., Rytting, M., Bomgaars, L.R., Rheingold, S., Ritchey, K., Albano, E., Arceci, R.J., Goldman, S., Griffin, T., Altman, A., Gordon, B., Steinherz, L., Weitman, S., Steinherz, P. J. Clin. Oncol. (2006) [Pubmed]
  9. Clofarabine: in pediatric patients with acute lymphoblastic leukemia. Curran, M.P., Perry, C.M. Paediatric drugs. (2005) [Pubmed]
  10. Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Kline, J.P., Larson, R.A. Expert opinion on pharmacotherapy. (2005) [Pubmed]
  11. Plasma and cerebrospinal fluid pharmacokinetics of clofarabine in nonhuman primates. Berg, S.L., Bonate, P.L., Nuchtern, J.G., Dauser, R., McGuffey, L., Bernacky, B., Blaney, S.M. Clin. Cancer Res. (2005) [Pubmed]
  12. Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance. Månsson, E., Flordal, E., Liliemark, J., Spasokoukotskaja, T., Elford, H., Lagercrantz, S., Eriksson, S., Albertioni, F. Biochem. Pharmacol. (2003) [Pubmed]
  13. The distribution, metabolism, and elimination of clofarabine in rats. Bonate, P.L., Arthaud, L., Stuhler, J., Yerino, P., Press, R.J., Rose, J.Q. Drug Metab. Dispos. (2005) [Pubmed]
  14. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Robak, T., Lech-Maranda, E., Korycka, A., Robak, E. Current medicinal chemistry (2006) [Pubmed]
  15. In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia. Beesley, A.H., Palmer, M.L., Ford, J., Weller, R.E., Cummings, A.J., Freitas, J.R., Firth, M.J., Perera, K.U., de Klerk, N.H., Kees, U.R. Br. J. Haematol. (2007) [Pubmed]
  16. Prognostic factors and therapeutic options for relapsed or refractory acute myeloid leukemia. Ferrara, F., Palmieri, S., Mele, G. Haematologica (2004) [Pubmed]
  17. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Zhang, Y., Secrist, J.A., Ealick, S.E. Acta Crystallogr. D Biol. Crystallogr. (2006) [Pubmed]
  18. Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine. Seedhouse, C., Grundy, M., Shang, S., Ronan, J., Pimblett, H., Russell, N., Pallis, M. Clin. Cancer Res. (2009) [Pubmed]
 
WikiGenes - Universities