Chemical Compound Review:
CPD-428 (3R,4S,5R,6S,7S,9R,11R,12S,13R ,14R)-14...
Synonyms:
CHEBI:16089, SureCN12266551, AC1L3TMD, LMPK04000002, AR-1K9308, ...
Ashley,
Carney,
Nagano,
Cupp-Vickery,
Poulos,
Ward,
Desai,
Hu,
Gramajo,
Katz,
Harris,
Cupp-Vickery,
Garcia,
Hofacre,
McGee-Estrada,
- Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Pfeifer, B.A., Admiraal, S.J., Gramajo, H., Cane, D.E., Khosla, C. Science (2001)
- A multiplasmid approach to preparing large libraries of polyketides. Xue, Q., Ashley, G., Hutchinson, C.R., Santi, D.V. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. Gokhale, R.S., Hunziker, D., Cane, D.E., Khosla, C. Chem. Biol. (1999)
- Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Tsai, S.C., Miercke, L.J., Krucinski, J., Gokhale, R., Chen, J.C., Foster, P.G., Cane, D.E., Khosla, C., Stroud, R.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Crystal structures of the ferrous dioxygen complex of wild-type cytochrome P450eryF and its mutants, A245S and A245T: investigation of the proton transfer system in P450eryF. Nagano, S., Cupp-Vickery, J.R., Poulos, T.L. J. Biol. Chem. (2005)
- Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. Chen, A.Y., Schnarr, N.A., Kim, C.Y., Cane, D.E., Khosla, C. J. Am. Chem. Soc. (2006)
- Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Wu, J., Kinoshita, K., Khosla, C., Cane, D.E. Biochemistry (2004)
- An acyl-carrier-protein-thioesterase domain from the 6-deoxyerythronolide B synthase of Saccharopolyspora erythraea. High-level production, purification and characterisation in Escherichia coli. Caffrey, P., Green, B., Packman, L.C., Rawlings, B.J., Staunton, J., Leadlay, P.F. Eur. J. Biochem. (1991)
- Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. Reeves, C.D., Murli, S., Ashley, G.W., Piagentini, M., Hutchinson, C.R., McDaniel, R. Biochemistry (2001)
- A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. Reid, R., Piagentini, M., Rodriguez, E., Ashley, G., Viswanathan, N., Carney, J., Santi, D.V., Hutchinson, C.R., McDaniel, R. Biochemistry (2003)
- Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea. Caffrey, P., Bevitt, D.J., Staunton, J., Leadlay, P.F. FEBS Lett. (1992)
- Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea. Weber, J.M., Leung, J.O., Maine, G.T., Potenz, R.H., Paulus, T.J., DeWitt, J.P. J. Bacteriol. (1990)
- Purification and reconstitution of the electron transport components for 6-deoxyerythronolide B hydroxylase, a cytochrome P-450 enzyme of macrolide antibiotic (erythromycin) biosynthesis. Shafiee, A., Hutchinson, C.R. J. Bacteriol. (1988)
- Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF. Cupp-Vickery, J.R., Garcia, C., Hofacre, A., McGee-Estrada, K. J. Mol. Biol. (2001)
- Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Tsai, S.C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M. Biochemistry (2002)
- Accumulation of 6-deoxyerythronolide B in a normal strain of Streptomyces erythreus and hydroxylation at carbon 6 of the erythranolide ring system by a soluble noninduced cell-free enzyme system. Corcoran, J.W., Vygantas, A.M. Biochemistry (1982)
- 6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering. Kennedy, J., Murli, S., Kealey, J.T. Biochemistry (2003)
- Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. Yin, Y., Gokhale, R., Khosla, C., Cane, D.E. Bioorg. Med. Chem. Lett. (2001)
- API-mass spectrometry of polyketides. II. Fragmentation analysis of 6-deoxyerythronolide B analogs. Ashley, G.W., Carney, J.R. J. Antibiot. (2004)
- Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF. Harris, D.L. J. Inorg. Biochem. (2002)
- Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. Murli, S., Kennedy, J., Dayem, L.C., Carney, J.R., Kealey, J.T. J. Ind. Microbiol. Biotechnol. (2003)
- Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. Ward, S.L., Desai, R.P., Hu, Z., Gramajo, H., Katz, L. J. Ind. Microbiol. Biotechnol. (2007)
- Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. Kumar, P., Li, Q., Cane, D.E., Khosla, C. J. Am. Chem. Soc. (2003)
- 6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme. Bevitt, D.J., Cortes, J., Haydock, S.F., Leadlay, P.F. Eur. J. Biochem. (1992)