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Chemical Compound Review

SureCN677650     2-amino-3-[4-(4- hydroxyphenoxy)-3-iodo...

Synonyms: AG-E-95515, AC1L3XAA, CTK4G3152, AK147620, 3-T1, ...
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Disease relevance of 3-monoiodothyronine


High impact information on 3-monoiodothyronine


Chemical compound and disease context of 3-monoiodothyronine


Biological context of 3-monoiodothyronine


Anatomical context of 3-monoiodothyronine


Associations of 3-monoiodothyronine with other chemical compounds

  • A high level of the thyroid hormone inactivating enzyme type 3 iodothyronine deiodinase (D3) was detected in her tumor, and the TSH of 26.2 mU/liter returned to normal after surgical resection of the mass [2].
  • 3. The inhibitory actions of amiodarone on beating rate and Na-K-ATPase activity were the same in myocytes grown in the presence or absence of 3-iodothyronine (T3, 5 nM) [16].

Gene context of 3-monoiodothyronine

  • The mouse Dio3 gene codes for the type 3 iodothyronine deiodinase (D3), a conserved selenocysteine-containing enzyme that inactivates thyroid hormones and is highly expressed during early development [17].
  • Regulation of type 3 iodothyronine deiodinase expression in cultured rat astrocytes: role of the Erk cascade [18].
  • Interestingly, the hypothyroidism-induced increase in cerebrocortical type 2 iodothyronine deiodinase activity was 3 times greater in the TR alpha1(PV/+) mice, and these mice had no T3-dependent induction of type 3 iodothyronine deiodinase [19].


  1. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. Huang, S.A., Tu, H.M., Harney, J.W., Venihaki, M., Butte, A.J., Kozakewich, H.P., Fishman, S.J., Larsen, P.R. N. Engl. J. Med. (2000) [Pubmed]
  2. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. Huang, S.A., Fish, S.A., Dorfman, D.M., Salvatore, D., Kozakewich, H.P., Mandel, S.J., Larsen, P.R. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  3. Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase. Galton, V.A., Martinez, E., Hernandez, A., St Germain, E.A., Bates, J.M., St Germain, D.L. J. Clin. Invest. (1999) [Pubmed]
  4. Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. Salvatore, D., Low, S.C., Berry, M., Maia, A.L., Harney, J.W., Croteau, W., St Germain, D.L., Larsen, P.R. J. Clin. Invest. (1995) [Pubmed]
  5. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. Baqui, M., Botero, D., Gereben, B., Curcio, C., Harney, J.W., Salvatore, D., Sorimachi, K., Larsen, P.R., Bianco, A.C. J. Biol. Chem. (2003) [Pubmed]
  6. Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase. Huang, S.A., Mulcahey, M.A., Crescenzi, A., Chung, M., Kim, B.W., Barnes, C., Kuijt, W., Turano, H., Harney, J., Larsen, P.R. Mol. Endocrinol. (2005) [Pubmed]
  7. Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients. Peeters, R.P., Wouters, P.J., Kaptein, E., van Toor, H., Visser, T.J., Van den Berghe, G. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  8. Spontaneous regression of severe acquired infantile hypothyroidism associated with multiple liver hemangiomas. Konrad, D., Ellis, G., Perlman, K. Pediatrics (2003) [Pubmed]
  9. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Curcio-Morelli, C., Gereben, B., Zavacki, A.M., Kim, B.W., Huang, S., Harney, J.W., Larsen, P.R., Bianco, A.C. Endocrinology (2003) [Pubmed]
  10. The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles. Becker, K.B., Stephens, K.C., Davey, J.C., Schneider, M.J., Galton, V.A. Endocrinology (1997) [Pubmed]
  11. Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1. Hernandez, A., Park, J.P., Lyon, G.J., Mohandas, T.K., St Germain, D.L. Genomics (1998) [Pubmed]
  12. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. Huang, S.A., Dorfman, D.M., Genest, D.R., Salvatore, D., Larsen, P.R. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  13. Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. McKinnon, B., Li, H., Richard, K., Mortimer, R. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  14. Induction of type 3 iodothyronine deiodinase by nerve injury in the rat peripheral nervous system. Li, W.W., Le Goascogne, C., Ramaugé, M., Schumacher, M., Pierre, M., Courtin, F. Endocrinology (2001) [Pubmed]
  15. Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Tu, H.M., Legradi, G., Bartha, T., Salvatore, D., Lechan, R.M., Larsen, P.R. Endocrinology (1999) [Pubmed]
  16. Effects of amiodarone on beating rate and Na-K-ATPase activity in cultured neonatal rat heart myocytes. Bergman, M., Cohen, F., Schlesinger, H., Kessler-Icekson, G. Gen. Pharmacol. (1995) [Pubmed]
  17. The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Hernandez, A., Fiering, S., Martinez, E., Galton, V.A., St Germain, D. Endocrinology (2002) [Pubmed]
  18. Regulation of type 3 iodothyronine deiodinase expression in cultured rat astrocytes: role of the Erk cascade. Pallud, S., Ramaugé, M., Gavaret, J.M., Lennon, A.M., Munsch, N., St Germain, D.L., Pierre, M., Courtin, F. Endocrinology (1999) [Pubmed]
  19. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Zavacki, A.M., Ying, H., Christoffolete, M.A., Aerts, G., So, E., Harney, J.W., Cheng, S.Y., Larsen, P.R., Bianco, A.C. Endocrinology (2005) [Pubmed]
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