Disease relevance of 3-monoiodothyronine

• Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas [1].
• A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase [2].

High impact information on 3-monoiodothyronine

• Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase [3].
• Type 3 iodothyronine deiodinase (D3) catalyzes the conversion of T4 and T3 to inactive metabolites [4].
• Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes [5].
• Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase [6].
• To study the mechanism(s) of the latter changes, we determined serum thyroid hormone levels and the expression of the type 1, 2, and 3 iodothyronine deiodinases (D1, D2, and D3) in liver and skeletal muscle from deceased intensive care patients [7].

Chemical compound and disease context of 3-monoiodothyronine

• His hypothyroidism corrected only after his L-thyroxine dose was progressively increased to 28 micro g/kg/d. At 6 months of age, multiple clinically asymptomatic hepatic hemangiomas were detected and support a diagnosis of consumptive hypothyroidism as a result of increased type 3 iodothyronine deiodinase activity in the hemangiomas [8].

Biological context of 3-monoiodothyronine

• In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases [9].
• The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles [10].
• Localization of the type 3 iodothyronine deiodinase (DIO3) gene to human chromosome 14q32 and mouse chromosome 12F1 [11].

Anatomical context of 3-monoiodothyronine

• The type 3 iodothyronine selenodeiodinase (D3) is an integral membrane protein that inactivates thyroid hormones [5].
• Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium [12].
• Modulation of trophoblast type 3 iodothyronine deiodinase (D3) may play an important role [13].
• Induction of type 3 iodothyronine deiodinase by nerve injury in the rat peripheral nervous system [14].
• Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone [15].

Associations of 3-monoiodothyronine with other chemical compounds

• A high level of the thyroid hormone inactivating enzyme type 3 iodothyronine deiodinase (D3) was detected in her tumor, and the TSH of 26.2 mU/liter returned to normal after surgical resection of the mass [2].
• 3. The inhibitory actions of amiodarone on beating rate and Na-K-ATPase activity were the same in myocytes grown in the presence or absence of 3-iodothyronine (T3, 5 nM) [16].

Gene context of 3-monoiodothyronine

• The mouse Dio3 gene codes for the type 3 iodothyronine deiodinase (D3), a conserved selenocysteine-containing enzyme that inactivates thyroid hormones and is highly expressed during early development [17].
• Regulation of type 3 iodothyronine deiodinase expression in cultured rat astrocytes: role of the Erk cascade [18].
• Interestingly, the hypothyroidism-induced increase in cerebrocortical type 2 iodothyronine deiodinase activity was 3 times greater in the TR alpha1(PV/+) mice, and these mice had no T3-dependent induction of type 3 iodothyronine deiodinase [19].

References