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Chemical Compound Review

CHEMBL443872     2-[(4-hydroxy-3,5-dimethyl...

Synonyms: KST-1A8012, CTK8E0042, AR-1A0021, AC1L2Q2W, AC1Q4PY3, ...
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Disease relevance of RG 50872


High impact information on RG 50872


Biological context of RG 50872


Anatomical context of RG 50872


Associations of RG 50872 with other chemical compounds

  • In the same culture conditions as for the fatty acid synthesis assay, cepharanthine, z-FFG and tyrphostin AG17 had no effect on the transcript levels of glucose transporter isoforms (GLUT 1, 4) and hexokinase isozymes (HK I, II) in rat white adipocytes [9].
  • PDGF-BB-stimulated GAG synthesis was abrogated by tyrphostin 9, a PDGF receptor-associated tyrosine kinase inhibitor, implying that the stimulatory effect is mediated via the PDGF beta-receptor (PDGFR) [10].


  1. Correspondence re: G. Palumbo et al., the tyrphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2. Cancer Res., 57: 2434-2439, 1997. Sausville, E.A. Cancer Res. (1997) [Pubmed]
  2. Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17. Liang, B.C., Ullyatt, E. Clin. Cancer Res. (1998) [Pubmed]
  3. Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1. Yura, Y., Kusaka, J., Kondo, Y., Tsujimoto, H., Yoshida, H., Sato, M. Arch. Virol. (1995) [Pubmed]
  4. Design of hypoxia-targeting protein tyrosine kinase inhibitor using an innovative pharmacophore 2-methylene-4-cyclopentene-1,3-dione. Hori, H., Nagasawa, H., Uto, Y., Ohkura, K., Kirk, K.L., Uehara, Y., Shimamura, M. Biochim. Biophys. Acta (2004) [Pubmed]
  5. STAT3 is essential for Hodgkin lymphoma cell proliferation and is a target of tyrphostin AG17 which confers sensitization for apoptosis. Holtick, U., Vockerodt, M., Pinkert, D., Schoof, N., Stürzenhofecker, B., Kussebi, N., Lauber, K., Wesselborg, S., Löffler, D., Horn, F., Trümper, L., Kube, D. Leukemia (2005) [Pubmed]
  6. Local delivery of an antiproliferative drug with use of hydrogel-coated angioplasty balloons. Consigny, P.M., Barry, J.J., Vitali, N.J. Journal of vascular and interventional radiology : JVIR. (1994) [Pubmed]
  7. Agonistic effects of tyrphostins on human peripheral mononuclear cells. Lander, H.M., Levine, D.M., Novogrodsky, A. Cell. Immunol. (1992) [Pubmed]
  8. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Hori, H., Nagasawa, H., Ishibashi, M., Uto, Y., Hirata, A., Saijo, K., Ohkura, K., Kirk, K.L., Uehara, Y. Bioorg. Med. Chem. (2002) [Pubmed]
  9. Modification of cell response to insulin by membrane-acting agents in rat white adipocytes: analysis of structural features by computational simulation. Ohkura, K., Hori, H. Bioorg. Med. Chem. (2001) [Pubmed]
  10. PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase. Liu, J., Fitzli, D., Liu, M., Tseu, I., Caniggia, I., Rotin, D., Post, M. Am. J. Physiol. (1998) [Pubmed]
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