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Chemical Compound Review

Amthamine     5-(2-aminoethyl)-4-methyl- 1,3-thiazol-2-amine

Synonyms: Tocris-0668, CHEMBL293762, KB-47389, CTK8E9579, AKOS006271424, ...
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High impact information on Amthamine

  • Using transiently transfected COS-7 cells expressing tagged-H2r, the desensitization induced by amthamine, characterized by decreased cAMP production, was studied [1].
  • Histamine and amthamine, a selective histamine H(2)-receptor agonist, concentration-dependently decreased myogenic tone, which was unchanged in the absence of endothelium [2].
  • Mesenteric bed dilation initiated by histamine H2 receptor selective agonists, amthamine and dimaprit, were antagonized markedly by tiotidine [3].
  • Whereas the increase in blood pressure induced by amthamine seems to be mainly mediated by a direct activation of postjunctional alpha 2 adrenoceptors, the increase in heart rate is predominantly due to neuronal release of catecholamines [4].
  • Amthamine was an effective secretagogue also in the rat isolated gastric fundus, behaving as a full agonist (EC50 = 18.9 mumol/l) [5].

Biological context of Amthamine


Anatomical context of Amthamine


Associations of Amthamine with other chemical compounds


  1. Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. Shayo, C., Fernandez, N., Legnazzi, B.L., Monczor, F., Mladovan, A., Baldi, A., Davio, C. Mol. Pharmacol. (2001) [Pubmed]
  2. Histamine decreases myogenic tone in rat cerebral arteries by H(2)-receptor-mediated K(V) channel activation, independent of endothelium and cyclic AMP. Jarajapu, Y.P., Oomen, C., Uteshev, V.V., Knot, H.J. Eur. J. Pharmacol. (2006) [Pubmed]
  3. Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed. Adeagbo, A.S., Oriowo, M.A. Eur. J. Pharmacol. (1998) [Pubmed]
  4. Cardiovascular effects of the novel histamine H2 receptor agonist amthamine: interaction with the adrenergic system. Coruzzi, G., Gambarelli, E., Bertaccini, G., Timmerman, H. Naunyn Schmiedebergs Arch. Pharmacol. (1996) [Pubmed]
  5. The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion. Coruzzi, G., Timmerman, H., Adami, M., Bertaccini, G. Naunyn Schmiedebergs Arch. Pharmacol. (1993) [Pubmed]
  6. Histamine and H2 agonist amthamine increase oxidative burst activity of human leukocytes determined by flow cytometry. Szeberényi, J.B., Orsó, E., László, V., Falus, A., Schmitz, G. Inflamm. Res. (2000) [Pubmed]
  7. Role of H(1) receptors in histamine-mediated up-regulation of STAT4 phosphorylation. Liu, Z., Kharmate, G., Patterson, E., Khan, M.M. Int. Immunopharmacol. (2006) [Pubmed]
  8. In vitro cardiac pharmacology of the new histamine H2-receptor agonist amthamine: comparisons with histamine and dimaprit. Poli, E., Pozzoli, C., Coruzzi, G., Bertaccini, G., Timmerman, H. Agents Actions (1993) [Pubmed]
  9. Histamine receptor-independent muscle relaxation elicited by a series of histamine H2-receptor agonists on the isolated guinea pig duodenum: a study into the mechanism of action. Coruzzi, G., Poli, E., Pozzoli, C., Bertaccini, G., Timmerman, H. Gen. Pharmacol. (1998) [Pubmed]
  10. Histamine protects against NMDA-induced necrosis in cultured cortical neurons through H receptor/cyclic AMP/protein kinase A and H receptor/GABA release pathways. Dai, H., Zhang, Z., Zhu, Y., Shen, Y., Hu, W., Huang, Y., Luo, J., Timmerman, H., Leurs, R., Chen, Z. J. Neurochem. (2006) [Pubmed]
  11. Influence of cyclooxygenase inhibitors on the central histaminergic stimulations of hypothalamic - pituitary - adrenal axis. Bugajski, A.J., Thor, P., Głód, R., Gadek-Michalska, A., Bugajski, J. J. Physiol. Pharmacol. (2003) [Pubmed]
  12. Involvement of nitric oxide in central histaminergic stimulation of the hypothalamic-pituitary-adrenal axis. Bugajski, A.J., Koprowska, B., Thor, P., Głod, R., Bugajski, J. J. Physiol. Pharmacol. (2000) [Pubmed]
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