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Chemical Compound Review

SureCN230460     2-methylquinolin-8-amine

Synonyms: NSC-7944, AG-A-44585, AG-E-38555, ACMC-209et1, ANW-23459, ...
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Disease relevance of NSC7944


High impact information on NSC7944


Biological context of NSC7944


Anatomical context of NSC7944

  • The widely used 8-aminoquinoline antimalarial group of compounds and the derivatives such as WR242511 that are being developed for possible prophylactic anticyanide applications have complex interactions with erythrocytes [15].

Associations of NSC7944 with other chemical compounds


Gene context of NSC7944


Analytical, diagnostic and therapeutic context of NSC7944


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  2. Phase 2 efficacy trial of an oral 8-aminoquinoline (WR6026) for treatment of visceral leishmaniasis. Sherwood, J.A., Gachihi, G.S., Muigai, R.K., Skillman, D.R., Mugo, M., Rashid, J.R., Wasunna, K.M., Were, J.B., Kasili, S.K., Mbugua, J.M. Clin. Infect. Dis. (1994) [Pubmed]
  3. Pharmacokinetics and kinetic-dynamic modeling of an 8-aminoquinoline candidate anticyanide and antimalarial drug (WR242511). Marino, M.T., Peggins, J.O., Brown, L.D., Urquhart, M.R., Brewer, T.G. Drug Metab. Dispos. (1994) [Pubmed]
  4. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Sweeney, A.W., Blackburn, C.R., Rieckmann, K.H. Am. J. Trop. Med. Hyg. (2004) [Pubmed]
  5. Poor gametocytocidal activity of 45 mg primaquine in chloroquine-treated patients with acute, uncomplicated, Plasmodium falciparum malaria in Mumbai (Bombay): an issue of public-health importance. Gogtay, N.J., Chogle, A.R., Sorabjee, J.S., Marathe, S.N., Kshirsagar, N.A. Ann. Trop. Med. Parasitol. (1999) [Pubmed]
  6. Modern malaria chemoprophylaxis. Shanks, G.D., Edstein, M.D. Drugs (2005) [Pubmed]
  7. Simple synthesis of aminoquinoline/ethylaniline copolymer semiconducting nanoparticles. Li, X.G., Hua, Y.M., Huang, M.R. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  8. Randomized dose-ranging study of the safety and efficacy of WR 238605 (Tafenoquine) in the prevention of relapse of Plasmodium vivax malaria in Thailand. Walsh, D.S., Looareesuwan, S., Wilairatana, P., Heppner, D.G., Tang, D.B., Brewer, T.G., Chokejindachai, W., Viriyavejakul, P., Kyle, D.E., Milhous, W.K., Schuster, B.G., Horton, J., Braitman, D.J., Brueckner, R.P. J. Infect. Dis. (1999) [Pubmed]
  9. Escalating multiple-dose safety and tolerance study of oral WR 6026 in HIV-infected subjects: AIDS clinical trials group 173. Petty, B.G., Black, J.R., Hendrix, C.W., Lewis, L.D., Basiakos, Y., Feinberg, J., Pattison, D.G., Hafner, R. J. Acquir. Immune Defic. Syndr. (1999) [Pubmed]
  10. Metabolism of a potential 8-aminoquinoline antileishmanial drug in rat liver microsomes. Theoharides, A.D., Chung, H., Velazquez, H. Biochem. Pharmacol. (1985) [Pubmed]
  11. Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs. McChesney, J.D. Bull. World Health Organ. (1981) [Pubmed]
  12. Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents. Idowu, O.R., Peggins, J.O., Brewer, T.G. Drug Metab. Dispos. (1995) [Pubmed]
  13. 8-Aminoquinolines: future role as antiprotozoal drugs. Tekwani, B.L., Walker, L.A. Curr. Opin. Infect. Dis. (2006) [Pubmed]
  14. Stimulation of ATP hydrolysis by chloroquine and primaquine in human red blood cells. Kelman, S.N., Sullivan, S.G., Stern, A. Biochemical medicine. (1983) [Pubmed]
  15. An improved pharmacodynamic model for formation of methemoglobin by antimalarial drugs. Fasanmade, A.A., Jusko, W.J. Drug Metab. Dispos. (1995) [Pubmed]
  16. Mutagenic activity and mutational specificity of antiprotozoal drugs with and without nitrite treatment. Ono-Ogata, T., Ogino, T., Nishikawa, M., Ohta, T., Yamagata, H. Environ. Mol. Mutagen. (2002) [Pubmed]
  17. Evaluation of sporontocidal compounds using Plasmodium falciparum gametocytes produced in vitro. Teklehaimanot, A., Nguyen-Dinh, P., Collins, W.E., Barber, A.M., Campbell, C.C. Am. J. Trop. Med. Hyg. (1985) [Pubmed]
  18. Preparation and in vitro evaluation of primaquine-conjugated gum arabic microspheres. Nishi, K.K., Jayakrishnan, A. Biomacromolecules (2004) [Pubmed]
  19. A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum. Hale, B.R., Owusu-Agyei, S., Fryauff, D.J., Koram, K.A., Adjuik, M., Oduro, A.R., Prescott, W.R., Baird, J.K., Nkrumah, F., Ritchie, T.L., Franke, E.D., Binka, F.N., Horton, J., Hoffman, S.L. Clin. Infect. Dis. (2003) [Pubmed]
  20. Development and validation of a stability-indicating reversed-phase high performance liquid chromatography method for NPC 1161C, a novel 8-aminoquinoline anti-malarial drug. Dutta, A.K., Avery, B.A., Wyandt, C.M. Journal of chromatography. A. (2006) [Pubmed]
  21. The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605. Peters, W., Robinson, B.L., Milhous, W.K. Ann. Trop. Med. Parasitol. (1993) [Pubmed]
  22. Gas chromatography mass spectrometry studies on biologically important 8-aminoquinoline derivatives. Baty, J.D., Price-Evans, D.A., Gilles, H.M., Greaves, J. Biomed. Mass Spectrom. (1978) [Pubmed]
  23. Orally effective drugs for kala-azar (visceral leishmaniasis): focus on miltefosine and sitamaquine. Sangraula, H., Sharma, K.K., Rijal, S., Dwivedi, S., Koirala, S. The Journal of the Association of Physicians of India. (2003) [Pubmed]
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