Disease relevance of Diketone

• Arildone is an aryl diketone which is inhibitory in vitro against herpes simplex virus type 2 at a concentration of 2 micrograms/ml or less [1].
• Cyclic phenylazomethines with methylene spacers (CPA-M) are obtained by dehydration of diamine with diketone [2].
• Diketone cleaving enzyme Dke1 production by Acinetobacter johnsonii--optimization of fermentation conditions [3].
• Neurofilamentous swellings and axonal atrophy are of unclear significance to diketone toxicity: commentary on forum position paper [4].
• The diketone compound, benzil is reduced to (S)-benzoin with living Bacillus cereus cells [5].

High impact information on Diketone

• The substrate specificity of the aldolase antibodies was directly related to the structure of the diketone used for selection [6].
• Reaction in D(2)O resulted in the incorporation of deuterium at the C-1, C-2, and C-5 positions of the diketone product [7].
• Trypanocidal 1,3-arylene diketone bis(guanylhydrazone)s. Structure-activity relationships among substituted and heterocyclic analogues [8].
• Based on the antitrypanosomal activity of 1,3-diacetylbenzene bis(guanylhydrazone) (4) and 2,6-diacetylpyridine bis(guanylhydrazone) (17), a number of substituted and heterocyclic 1,3-arylene diketone bis(guanylhydrazone)s were prepared and tested against Trypanosoma brucei infections in mice [8].
• The best results were obtained with hydroxy ketones 2, 4 and 5 and diketone 7 exhibiting activities against S. cerevisiae (ATCC 28383) and Candida albicans (CIP 1663-86) [9].

Chemical compound and disease context of Diketone

• Among them, alpha-trifluoromethyl diketone (2) and benzyl trifluoromethyl ketone (11) were found to be apoptosis inhibitors which can prevent a neurodegenerative disease [10].

Biological context of Diketone

• Inhalation toxicology studies have shown severe respiratory effects in rats exposed to vapors from a paste butter flavoring, and to diacetyl, a diketone found in most butter flavorings [11].
• On the other hand, hydrogenation at conjugated double bonds of the central seven carbon chain and beta diketone of curcumin to THC, HHC and OHC remarkably enhance antioxidant activity [12].

Anatomical context of Diketone

• Rapid reorganization of the axonal cytoskeleton induced by a gamma diketone [13].

Associations of Diketone with other chemical compounds

• In contrast, N-ethylmaleimide (NEM), another alpha,beta-unsaturated diketone with thiol-reactive properties similar to those of p-BQ, inhibited all of these Con A-induced activation events [14].
• Modification and derivatization of the C10 position were carried out using a substrate controlled hydride addition to a key C9 and C10 diketone intermediate [15].
• The enzyme had an extremely narrow substrate specificity and it highly reduced conjugated diketone, 2,3-butanedion, in addition to ethyl 4-chloro-3-oxobutanoate [16].
• GMA-cyclic diketone carbon acid monomer mixtures incorporating imidazole polymerize smoothly without obvious exothermicity at temperatures ranging from ambient to -5 C without the use of ultraviolet light [17].

Gene context of Diketone

• A geranyl-derived isoprenoid diketone, 5,9-dimethyl-8-decene-2,3-dione, at 17 microM caused a 62% reduction in FTase activity after 30 minutes [18].
• The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol [19].

Analytical, diagnostic and therapeutic context of Diketone

• The maximum conduction velocity of motor and sensory fibres and the motor distal latency of the tail nerves of rats were periodically examined in animals receiving repeated subcutaneous injections of 11 aliphatic monoketone or diketone compounds and their relatives for prolonged periods [20].

References