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Chemical Compound Review

Diketone     2,3-dichloro-5- (dichloromethylidene)cyclop...

Synonyms: AG-E-38469, SureCN11415965, LS-58314, CTK4E0186, AR-1F8330, ...
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Disease relevance of Diketone


High impact information on Diketone


Chemical compound and disease context of Diketone


Biological context of Diketone


Anatomical context of Diketone


Associations of Diketone with other chemical compounds

  • In contrast, N-ethylmaleimide (NEM), another alpha,beta-unsaturated diketone with thiol-reactive properties similar to those of p-BQ, inhibited all of these Con A-induced activation events [14].
  • Modification and derivatization of the C10 position were carried out using a substrate controlled hydride addition to a key C9 and C10 diketone intermediate [15].
  • The enzyme had an extremely narrow substrate specificity and it highly reduced conjugated diketone, 2,3-butanedion, in addition to ethyl 4-chloro-3-oxobutanoate [16].
  • GMA-cyclic diketone carbon acid monomer mixtures incorporating imidazole polymerize smoothly without obvious exothermicity at temperatures ranging from ambient to -5 C without the use of ultraviolet light [17].

Gene context of Diketone

  • A geranyl-derived isoprenoid diketone, 5,9-dimethyl-8-decene-2,3-dione, at 17 microM caused a 62% reduction in FTase activity after 30 minutes [18].
  • The diketone analogues, 10-hydroxymethyl-8,13-eicosanedione (24), 10-acetoxymethyl-8,13-eicosanedione (25), and 10-methoxymethyl-8,13-eicosanedione (26) each inhibited PKC activated by 2-O-acetyl-1-O-oleoylglycerol [19].

Analytical, diagnostic and therapeutic context of Diketone

  • The maximum conduction velocity of motor and sensory fibres and the motor distal latency of the tail nerves of rats were periodically examined in animals receiving repeated subcutaneous injections of 11 aliphatic monoketone or diketone compounds and their relatives for prolonged periods [20].


  1. A placebo-controlled trial of topical 8% arildone cream early in recurrent genital herpes. Douglas, J.M., Judson, F.N., Levin, M.J., Bosso, J.A., Spruance, S.L., Johnston, J.M., Corey, L., McMillan, J.A., Weiner, L.B., Frank, J.A. Antimicrob. Agents Chemother. (1986) [Pubmed]
  2. Sequential metal ion assembly in cyclic phenylazomethine. Higuchi, M., Shomura, R., Ohtsuka, Y., Hayashi, A., Yamamoto, K., Kurth, D.G. Org. Lett. (2006) [Pubmed]
  3. Diketone cleaving enzyme Dke1 production by Acinetobacter johnsonii--optimization of fermentation conditions. Hofer, H., Mandl, T., Steiner, W. J. Biotechnol. (2004) [Pubmed]
  4. Neurofilamentous swellings and axonal atrophy are of unclear significance to diketone toxicity: commentary on forum position paper. Sickles, D.W. Neurotoxicology (1997) [Pubmed]
  5. The enzymes with benzil reductase activity conserved from bacteria to mammals. Maruyama, R., Nishizawa, M., Itoi, Y., Ito, S., Inoue, M. J. Biotechnol. (2002) [Pubmed]
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  7. S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein. Zhu, J., Dizin, E., Hu, X., Wavreille, A.S., Park, J., Pei, D. Biochemistry (2003) [Pubmed]
  8. Trypanocidal 1,3-arylene diketone bis(guanylhydrazone)s. Structure-activity relationships among substituted and heterocyclic analogues. Ulrich, P., Cerami, A. J. Med. Chem. (1984) [Pubmed]
  9. Synthesis and antifungal activity of oxygenated cholesterol derivatives. Brunel, J.M., Loncle, C., Vidal, N., Dherbomez, M., Letourneux, Y. Steroids (2005) [Pubmed]
  10. Trifluoromethyl ketone-based inhibitors of apoptosis in cerebellar granule neurons. Kawase, n.u.l.l., Sunaga, K., Tani, S., Niwa, M., Uematsu, T. Biol. Pharm. Bull. (2001) [Pubmed]
  11. Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn production. Boylstein, R., Piacitelli, C., Grote, A., Kanwal, R., Kullman, G., Kreiss, K. Journal of occupational and environmental hygiene. (2006) [Pubmed]
  12. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., Morales, N.P. Biol. Pharm. Bull. (2007) [Pubmed]
  13. Rapid reorganization of the axonal cytoskeleton induced by a gamma diketone. Zagoren, J.C., Politis, M.J., Spencer, P.S. Brain Res. (1983) [Pubmed]
  14. The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression. Geiselhart, L.A., Christian, T., Minnear, F., Freed, B.M. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  15. Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Spletstoser, J.T., Turunen, B.J., Desino, K., Rice, A., Datta, A., Dutta, D., Huff, J.K., Himes, R.H., Audus, K.L., Seelig, A., Georg, G.I. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  16. Purification and properties of a carbonyl reductase involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate from Cylindrocarpon sclerotigenum IFO 31855. Saratani, Y., Uheda, E., Yamamoto, H., Nishimura, A., Yoshizako, F. Biosci. Biotechnol. Biochem. (2003) [Pubmed]
  17. Initiating polymerization of glycol methacrylate with cyclic diketo carbon acids. Ruddell, C.L. Stain technology. (1983) [Pubmed]
  18. Inactivation of protein farnesyltransferase by active-site-targeted dicarbonyl compounds. Okolotowicz, K.J., Lee, W.J., Hartman, R.F., Kim, A.Y., Ottersberg, S.R., Robinson, D.E., Lefler, S.R., Rose, S.D. Arch. Pharm. (Weinheim) (2001) [Pubmed]
  19. Synthesis of diacylglycerol analogues as potential second-messenger antagonists and inhibitors of protein kinase C. Briggs, J.C., Haines, A.H., Taylor, R.J., Dawson, A.P., Gibson, I., Hook, J., Lloyd, A., Meiners, S. Carbohydr. Res. (1992) [Pubmed]
  20. Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats. Misumi, J., Nagano, M. British journal of industrial medicine. (1984) [Pubmed]
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