Chemical Compound Review:
Gacyclidine 1-[(1R,2S)-2-methyl-1- thiophen-2-yl...
Synonyms:
GK-11, PubChem24062, GK11, SureCN397836, CHEMBL1742478, ...
Gaviria,
Privat,
d'Arbigny,
Kamenka,
Haton,
Ohanna,
Hannan,
Hoizey,
Lamiable,
Dukic,
Millart,
d'Arbigny,
Vistelle,
Feldblum,
Arnaud,
Simon,
Rabin,
D'Arbigny,
Hoizey,
Kaltenbach,
Dukic,
Lamiable,
Lallemand,
D'Arbigny,
Millart,
Vistelle,
Hoizey,
Kaltenbach,
Dukic,
Lamiable,
Lallemand,
Millart,
D'Arbigny,
Vistelle,
Gaviria,
Privat,
d'Arbigny,
Kamenka,
Haton,
Ohanna,
- Acute soman poisoning in primates neither pretreated nor receiving immediate therapy: value of gacyclidine (GK-11) in delayed medical support. Lallement, G., Clarençon, D., Galonnier, M., Baubichon, D., Burckhart, M.F., Peoc'h, M. Arch. Toxicol. (1999)
- Gacyclidine: a new neuroprotective agent acting at the N-methyl-D-aspartate receptor. Hirbec, H., Gaviria, M., Vignon, J. CNS drug reviews. (2001)
- Characterization of 'non-N-methyl-D-Aspartate' binding sites for gacyclidine enantiomers in the rat cerebellar and telencephalic structures. Hirbec, H., Kamenka, J.M., Privat, A., Vignon, J. J. Neurochem. (2001)
- Neuroprotective effects of gacyclidine after experimental photochemical spinal cord lesion in adult rats: dose-window and time-window effects. Gaviria, M., Privat, A., d'Arbigny, P., Kamenka, J.M., Haton, H., Ohanna, F. J. Neurotrauma (2000)
- Interaction of gacyclidine enantiomers with 'non-NMDA' binding sites in the rat central nervous system. Hirbec, H., Kamenka, J.M., Privat, A., Vignon, J. Brain Res. (2001)
- Distribution of gacyclidine enantiomers after experimental spinal cord injury in rats: possible involvement of an active transport system. Hoizey, G., Kaltenbach, M.L., Dukic, S., Lamiable, D., Lallemand, A., Millart, H., D'Arbigny, P., Vistelle, R. Journal of pharmaceutical sciences. (2001)
- Distribution of gacyclidine enantiomers in spinal cord extracellular fluid. Hoizey, G., Kaltenbach, M.L., Dukic, S., Lamiable, D., Lallemand, A., D'Arbigny, P., Millart, H., Vistelle, R. Pharm. Res. (2000)
- Binding properties of [3H]gacyclidine (cis(pip/me)-1-[1-(2-thienyl)-2-methylcyclohexyl]piperidine) enantiomers in the rat central nervous system. Hirbec, H., Teilhac, J., Kamenka, J., Privat, A., Vignon, J. Brain Res. (2000)
- Binding properties of [3H]gacyclidine in the rat central nervous system. Hirbec, H., Privat, A., Vignon, J. Eur. J. Pharmacol. (2000)
- Neuroprotective effects of a novel NMDA antagonist, Gacyclidine, after experimental contusive spinal cord injury in adult rats. Gaviria, M., Privat, A., d'Arbigny, P., Kamenka, J., Haton, H., Ohanna, F. Brain Res. (2000)
- FENS 2000--Federation of European Neuroscience Societies. 24-28 June 2000, Brighton, UK. Hannan, A. IDrugs : the investigational drugs journal. (2000)
- Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman. Lallement, G., Baubichon, D., Clarençon, D., Galonnier, M., Peoc'h, M., Carpentier, P. Neurotoxicology (1999)
- Determination of gacyclidine enantiomers in human plasma by gas chromatography-mass spectrometry using selected-ion monitoring. Hoizey, G., Vistelle, R., Lamiable, D., Millart, H., Gourdier, B., d'Arbigny, P. J. Chromatogr. B Biomed. Sci. Appl. (1997)
- Efficacy of a new neuroprotective agent, gacyclidine, in a model of rat spinal cord injury. Feldblum, S., Arnaud, S., Simon, M., Rabin, O., D'Arbigny, P. J. Neurotrauma (2000)
- Sensitive gas chromatographic-mass spectrometric method for the determination of gacyclidine in rat plasma and spinal cord dialyzates. Hoizey, G., Lamiable, D., Dukic, S., Millart, H., d'Arbigny, P., Vistelle, R. The Analyst. (1999)
- The novel non-competitive N-methyl-D-aspartate antagonist gacyclidine blocks the glutamate-induced release of hydroxyl radicals in the striatum under conditions in which dizocilpine does not. A microdialysis study in rats. Laplanche, L., Kamenka, J.M., Barbanel, G. Neurosci. Lett. (2000)