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Chemical Compound Review

Arogenate     1-(2-amino-2-carboxy-ethyl)- 4-hydroxy...

Synonyms: Pretyrosine, Arogenic acid, AG-J-04656, SureCN2813983, SureCN9885027, ...
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Disease relevance of Pretyrosine


High impact information on Pretyrosine


Biological context of Pretyrosine


Associations of Pretyrosine with other chemical compounds

  • A novel natural product structurally related to prephenate and arogenate was isolated from a mutant of Neurospora crassa [12].
  • Thus, subgroup Ia species lack an unregulated isozyme of chorismate mutase and arogenate dehydratase, enzymes which are thought to divert chorismate to L-phenylalanine under conditions of high carbon input into aromatic biosynthesis [13].

Gene context of Pretyrosine

  • The molecular weight of arogenate dehydrogenase is about 68,000, and SDS gel electrophoresis indicates a composition of two identical subunits [14].

Analytical, diagnostic and therapeutic context of Pretyrosine


  1. Arogenate (pretyrosine) is an obligatory intermediate of L-tyrosine biosynthesis: confirmation in a microbial mutant. Fazel, A.M., Bowen, J.R., Jensen, R.A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. Enzymatic and nonenzymatic dehydration reactions of L-arogenate. Zamir, L.O., Tiberio, R., Fiske, M., Berry, A., Jensen, R.A. Biochemistry (1985) [Pubmed]
  3. Biochemical diversity for biosynthesis of aromatic amino acids among the cyanobacteria. Hall, G.C., Flick, M.B., Gherna, R.L., Jensen, R.A. J. Bacteriol. (1982) [Pubmed]
  4. Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. Rippert, P., Matringe, M. Eur. J. Biochem. (2002) [Pubmed]
  5. A simple spectrophotometric assay for arogenate dehydratase. Ahmad, S., Jensen, R.A. Anal. Biochem. (1987) [Pubmed]
  6. Cyclohexadienyl dehydratase from Pseudomonas aeruginosa. Molecular cloning of the gene and characterization of the gene product. Zhao, G.S., Xia, T.H., Fischer, R.S., Jensen, R.A. J. Biol. Chem. (1992) [Pubmed]
  7. Isolation and structure determination of a novel spiro-gamma-lactam, spiro-arogenate. Zamir, L.O., Tiberio, R., Jung, E., Jensen, R.A. J. Biol. Chem. (1983) [Pubmed]
  8. Molecular and biochemical characterization of an Arabidopsis thaliana arogenate dehydrogenase with two highly similar and active protein domains. Rippert, P., Matringe, M. Plant Mol. Biol. (2002) [Pubmed]
  9. Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench. Siehl, D.L., Conn, E.E. Arch. Biochem. Biophys. (1988) [Pubmed]
  10. Biochemical characterization and crystal structure of Synechocystis arogenate dehydrogenase provide insights into catalytic reaction. Legrand, P., Dumas, R., Seux, M., Rippert, P., Ravelli, R., Ferrer, J.L., Matringe, M. Structure (2006) [Pubmed]
  11. A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. Bonner, C.A., Jensen, R.A., Gander, J.E., Keyhani, N.O. Biochem. J. (2004) [Pubmed]
  12. Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. Zamir, L.O., Tiberio, R., Devor, K.A., Sauriol, F., Ahmad, S., Jensen, R.A. J. Biol. Chem. (1988) [Pubmed]
  13. Evolution of L-phenylalanine biosynthesis in rRNA homology group I of Pseudomonas. Byng, G.S., Whitaker, R.J., Jensen, R.A. Arch. Microbiol. (1983) [Pubmed]
  14. Purification and properties of arogenate dehydrogenase from Actinoplanes missouriensis. Hund, H.K., Bär, G., Lingens, F. Z. Naturforsch., C, J. Biosci. (1989) [Pubmed]
  15. Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase. Connelly, J.A., Conn, E.E. Z. Naturforsch., C, J. Biosci. (1986) [Pubmed]
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